LHFPL5 - LHFPL tetraspan subfamily member 5 Gene
Also Known as TMHS; DFNB67; dJ510O8.8
Species: Homo sapiens
About LHFPL5
This gene has 6 transcripts (splice variants), 262 orthologues, 6 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.
Summary
This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in this gene result in deafness in humans, and a mutation in a similar gene in mice results in deafness and vestibular dysfunction with severe degeneration of the organ of Corti. It is proposed to function in hair bundle morphogenesis. [provided by RefSeq, Jul 2008]
LHFPL5 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_182548.4 | NP_872354.1 | LHFPL tetraspan subfamily member 5 protein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
LHFPL5 Protein Structure
L_HMGIC_fpl: Lipoma HMGIC fusion partner-like protein (25 - 202)
- 0
- 100
- 200
- 219 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
LHFPL tetraspan subfamily member 5 protein |
|
LHFPL5 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
LHFPL5 | Q8TAF8 | SLC35B4 | Homo sapiens | Q969S0 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TMEM248 | Homo sapiens | Q9NWD8 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TMEM248 | Homo sapiens | Q9NWD8 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TMEM248 | Homo sapiens | Q9NWD8 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | NINJ2 | Homo sapiens | Q9NZG7 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TEX264 | Homo sapiens | Q9Y6I9 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | SERP1 | Homo sapiens | Q9Y6X1 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TMX1 | Homo sapiens | Q9H3N1 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TMX1 | Homo sapiens | Q9H3N1 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TMX1 | Homo sapiens | Q9H3N1 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | RPRM | Homo sapiens | Q9NS64 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | VMA21 | Homo sapiens | Q3ZAQ7 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | VMA21 | Homo sapiens | Q3ZAQ7 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | RMDN3 | Homo sapiens | Q96TC7 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | RMDN3 | Homo sapiens | Q96TC7 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | RMDN3 | Homo sapiens | Q96TC7 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GGT7 | Homo sapiens | Q9UJ14 | 25910212 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GGT7 | Homo sapiens | Q9UJ14 | 33961781 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GGT7 | Homo sapiens | Q9UJ14 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GGT7 | Homo sapiens | Q9UJ14 | 25416956 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GGT7 | Homo sapiens | Q9UJ14 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GGT7 | Homo sapiens | Q9UJ14 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GGT7 | Homo sapiens | Q9UJ14 | 25910212 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GGT7 | Homo sapiens | Q9UJ14 | 25910212 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GGT7 | Homo sapiens | Q9UJ14 | 25910212 | |
|
Intra
|
LHFPL5 | Q8TAF8 | LRRC25 | Homo sapiens | Q8N386 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | LRRC25 | Homo sapiens | Q8N386 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | MFF | Homo sapiens | Q9GZY8-5 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | MFF | Homo sapiens | Q9GZY8-5 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | MFF | Homo sapiens | Q9GZY8-5 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TMEM254 | Homo sapiens | Q8TBM7 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | LPAR3 | Homo sapiens | Q9UBY5 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | LNPEP | Homo sapiens | Q9UIQ6-2 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | FNDC9 | Homo sapiens | Q8TBE3 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | FNDC9 | Homo sapiens | Q8TBE3 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | FNDC9 | Homo sapiens | Q8TBE3 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | AQP2 | Homo sapiens | P41181 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | AQP2 | Homo sapiens | P41181 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | DAGLA | Homo sapiens | Q9Y4D2 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | SLC34A2 | Homo sapiens | O95436-2 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | SLC34A2 | Homo sapiens | O95436-2 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GJB4 | Homo sapiens | Q9NTQ9 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GJB4 | Homo sapiens | Q9NTQ9 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GJB4 | Homo sapiens | Q9NTQ9 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | ZDHHC15 | Homo sapiens | Q96MV8 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GPRC5D | Homo sapiens | Q9NZD1 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GPRC5D | Homo sapiens | Q9NZD1 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GJB6 | Homo sapiens | O95452 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GJB6 | Homo sapiens | O95452 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TM4SF18 | Homo sapiens | Q96CE8 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TM4SF18 | Homo sapiens | Q96CE8 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TM4SF18 | Homo sapiens | Q96CE8 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | HAS3 | Homo sapiens | O00219-2 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | HAS3 | Homo sapiens | O00219-2 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | AQP9 | Homo sapiens | O43315 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | AQP9 | Homo sapiens | O43315 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GJA8 | Homo sapiens | P48165 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GJA8 | Homo sapiens | P48165 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CLEC14A | Homo sapiens | Q86T13 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CLEC14A | Homo sapiens | Q86T13 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | ADGRG3 | Homo sapiens | Q86Y34 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | ADGRG3 | Homo sapiens | Q86Y34 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GPR42 | Homo sapiens | O15529 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GPR42 | Homo sapiens | O15529 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TMEM52B | Homo sapiens | Q4KMG9 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TMEM52B | Homo sapiens | Q4KMG9 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CLDN5 | Homo sapiens | O00501 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CLDN5 | Homo sapiens | O00501 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | HLA-DQA2 | Homo sapiens | P01906 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | HLA-DQA2 | Homo sapiens | P01906 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CERS4 | Homo sapiens | Q9HA82 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CERS4 | Homo sapiens | Q9HA82 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CERS4 | Homo sapiens | Q9HA82 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CMTM7 | Homo sapiens | Q96FZ5 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | UBIAD1 | Homo sapiens | Q9Y5Z9 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | LIME1 | Homo sapiens | Q9H400 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | LIME1 | Homo sapiens | Q9H400 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | LIME1 | Homo sapiens | Q9H400 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | FFAR2 | Homo sapiens | O15552 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | FFAR2 | Homo sapiens | O15552 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TMEM60 | Homo sapiens | Q9H2L4 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | FCGR1A | Homo sapiens | P12314 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | FCGR1A | Homo sapiens | P12314 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GJB2 | Homo sapiens | P29033 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GJB2 | Homo sapiens | P29033 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GJB3 | Homo sapiens | O75712 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | GJB3 | Homo sapiens | O75712 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | PLLP | Homo sapiens | Q9Y342 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | MTIF3 | Homo sapiens | Q9H2K0 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | MTIF3 | Homo sapiens | Q9H2K0 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | MTIF3 | Homo sapiens | Q9H2K0 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | LRRC4C | Homo sapiens | Q9HCJ2 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | LRRC4C | Homo sapiens | Q9HCJ2 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | LRRC4C | Homo sapiens | Q9HCJ2 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | KCNK5 | Homo sapiens | O95279 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | KCNK5 | Homo sapiens | O95279 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CREB3 | Homo sapiens | O43889-2 | 25910212 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CREB3 | Homo sapiens | O43889-2 | 25910212 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CREB3 | Homo sapiens | O43889-2 | 25910212 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CREB3 | Homo sapiens | O43889-2 | 31515488 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TIMMDC1 | Homo sapiens | Q9NPL8 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TIMMDC1 | Homo sapiens | Q9NPL8 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TIMMDC1 | Homo sapiens | Q9NPL8 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TMX2 | Homo sapiens | Q9Y320 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TMX2 | Homo sapiens | Q9Y320 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TMX2 | Homo sapiens | Q9Y320 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CD53 | Homo sapiens | P19397 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CD53 | Homo sapiens | P19397 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | ERG28 | Homo sapiens | Q9UKR5 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | FXYD6 | Homo sapiens | Q9H0Q3 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | PDZK1IP1 | Homo sapiens | Q13113 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | PDZK1IP1 | Homo sapiens | Q13113 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | KASH5 | Homo sapiens | Q8N6L0 | 25910212 | |
|
Intra
|
LHFPL5 | Q8TAF8 | KASH5 | Homo sapiens | Q8N6L0 | 25416956 | |
|
Intra
|
LHFPL5 | Q8TAF8 | KASH5 | Homo sapiens | Q8N6L0 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | KASH5 | Homo sapiens | Q8N6L0 | 25416956 | |
|
Intra
|
LHFPL5 | Q8TAF8 | KASH5 | Homo sapiens | Q8N6L0 | 25910212 | |
|
Intra
|
LHFPL5 | Q8TAF8 | KASH5 | Homo sapiens | Q8N6L0 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | KASH5 | Homo sapiens | Q8N6L0 | 25910212 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CD79A | Homo sapiens | P11912 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | CD79A | Homo sapiens | P11912 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | INSIG2 | Homo sapiens | Q9Y5U4 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | KIR2DL3 | Homo sapiens | P43628 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | KIR2DL3 | Homo sapiens | P43628 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | RUSF1 | Homo sapiens | Q96GQ5 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | NRG4 | Homo sapiens | Q8WWG1 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | TMEM100 | Homo sapiens | Q9NV29 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | BTN2A2 | Homo sapiens | Q8WVV5 | 32296183 | |
|
Intra
|
LHFPL5 | Q8TAF8 | SEC22A | Homo sapiens | Q96IW7 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Deafness, Autosomal Recessive 67 |
|
|
| Autosomal Recessive Intellectual Developmental Disorder |
|
|
| Autosomal Recessive Non-Syndromic Intellectual Disability |
|
|
| Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb |
|
|
| Autosomal Recessive Nonsyndromic Deafness |
|
|
| Deafness, Autosomal Recessive |
|
|
| Ear Malformation |
|
|
| Deafness, Autosomal Recessive 6 |
|
|
| Deafness, Autosomal Recessive 83 |
|
|
| Deafness, Autosomal Recessive 85 |
|
|
| Deafness, Autosomal Dominant 36 |
|
|
| Usher Syndrome, Type Iiia |
|
|
| Sensorineural Hearing Loss |
|
|
| Deafness, Autosomal Recessive 16 |
|
|
| Deafness, Autosomal Recessive 1b |
|
|
| Deafness, Autosomal Dominant 3b |
|
|
| Deafness, Autosomal Recessive 23 |
|
|
| Deafness, Autosomal Dominant 2a |
|
|
| Deafness, Autosomal Recessive 63 |
|
|
| Louping Ill |
|
|
| Deafness, Autosomal Dominant 25 |
|
|
| Deafness, Autosomal Recessive 12 |
|
|
| Autosomal Dominant Nonsyndromic Deafness |
|
|
| Auditory System Disease |
|
|
| Usher Syndrome, Type I |
|
|
| Usher Syndrome |
|
|
| Retinitis Pigmentosa |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | LHFPL5 | MGD | MGI:1915382 |
| Felis catus | LHFPL5 | VGNC | VGNC:102448 |
| Rattus norvegicus | LHFPL5 | RGD | RGD:1359370 |
| Macaca mulatta | LHFPL5 | VGNC | VGNC:74098 |
| Bos taurus | LHFPL5 | VGNC | VGNC:30868 |
| Canis familiaris | LHFPL5 | VGNC | VGNC:42660 |
| Others | LHFPL5 | NCBI |