HLA-DQA2 - major histocompatibility complex, class II, DQ alpha 2 Gene

Also Known as DQA1; HLA-DCA; HLA-DXA; HLADQA2; DC-alpha; DX-ALPHA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3118

About HLA-DQA2

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,741,391-32,747,198 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 542 orthologues, 13 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 32.9), spleen (RPKM 26.8) and 20 other tissues.

Summary

This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq, Jun 2010]

HLA-DQA2 Products (1)

mRNA Protein Name
NM_020056.5 NP_064440.1 HLA class II histocompatibility antigen, DQ alpha 2 chain precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLA-DQA2 Protein Structure

MHC_II_alpha

MHC_II_alpha: Class II histocompatibility antigen, alpha domain (29 - 110)

C1-set

C1-set: Immunoglobulin C1-set domain (122 - 200)

  • 0
  • 100
  • 200
  • 255 a.a.
Protein Preferred Names Protein Names

HLA class II histocompatibility antigen, DQ alpha 2 chain

  • DC-1 alpha chain

HLA-DQA2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HLA-DQA2 P01906 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Penis Carcinoma In Situ

  • Carcinoma In Situ Of Penis

  • Bowen'S Disease Of Penis

  • Grade Iii Squamous Intraepithelial Lesion Of Penis

  • Penile Intraepithelial Neoplasia Grade Iii

  • Queyrat'S Erythroplasia

  • Erythroplasia Of Queyrat

  • Pin - [Penile Intraepithelial Neoplasia]
Podoconiosis

  • PDCOS

  • Podoconiosis, Susceptibility To

  • Nonfilarial Elephantiasis Of Lower Legs

  • Nonfilarial Elephantiasis Of Lower Legs, Susceptibility To

  • Endemic Nonfilarial Elephantiasis

  • Endemic Nonfilarial Elephantiasis, Susceptibility To

  • Lymphostatic Verrucosis

  • Lymphostatic Verrucosis, Susceptibility To

  • Elephantiasis

  • Endemic Non-Filarial Elephantiasis
Narcolepsy

  • Paroxysmal Sleep

  • Gelineau Syndrome

  • Narcoleptic Syndrome

  • Narcolepsy-Cataplexy Syndrome

  • Cataplexy And Narcolepsy

  • Narcolepsy, Without Cataplexy

  • Gelineau'S Syndrome

  • Narcolepsy With Or Without Cataplexy

  • Narcolepsy Nos
Type 1 Diabetes Mellitus 12

  • Diabetes Mellitus, Insulin-Dependent, 12

  • IDDM12

  • Insulin-Dependent Diabetes Mellitus 12

  • T1D12

  • Type 1 Diabetes Mellitus 12, Susceptibility To

  • Diabetes Mellitus, Insulin-Dependent, Type 12
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Gastroduodenal Crohn'S Disease

  • Upper Gi Crohn'S Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06206 HLA-DQA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HLA-DQA2 MGD MGI:95895