CMTM7 - CKLF like MARVEL transmembrane domain containing 7 Gene

Homo sapiens

Also known as CKLFSF7

Gene ID: 112616 | Gene type: protein coding

About CMTM7

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:32,391,853-32,455,528 (from NCBI)

This gene has 6 transcripts (splice variants), 194 orthologues and 14 paralogues. Broad expression in lymph node (RPKM 7.5), spleen (RPKM 7.1) and 25 other tissues.

Summary

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

CMTM7 Products(2)

mRNA	Protein	Name
NM_138410.4	NP_612419.1	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform a
NM_181472.3	NP_852137.1	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform b

CMTM7 Protein Structure

MARVEL

0
100
175 a.a.

Protein Preferred Names

Protein Names

CKLF-like MARVEL transmembrane domain-containing protein 7

chemokine-like factor super family 7

Related Diseases

Diseases

Alias

Mayer-Rokitansky-Kuster-Hauser Syndrome Type 1

Rokitansky Sequence	Congenital Absence Of Uterus And Vagina
Mrkh Syndrome Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02869	CMTM7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CMTM7	VGNC	VGNC:61003
Canis familiaris	CMTM7	VGNC	VGNC:52872
Mus musculus	CMTM7	MGD	MGI:2447166
Macaca mulatta	CMTM7	VGNC	VGNC:71218
Rattus norvegicus	CMTM7	RGD	RGD:1591926
Bos taurus	CMTM7	VGNC	VGNC:27487

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