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CMTM7 - CKLF like MARVEL transmembrane domain containing 7 Gene

Also Known as CKLFSF7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 112616

About CMTM7

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:32,391,853-32,455,528 (from NCBI)

This gene has 6 transcripts (splice variants), 194 orthologues and 14 paralogues. Broad expression in lymph node (RPKM 7.5), spleen (RPKM 7.1) and 25 other tissues.

Summary

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

CMTM7 Products (2)

mRNA	Protein	Name
NM_138410.4	NP_612419.1	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform a
NM_181472.3	NP_852137.1	CKLF-like MARVEL transmembrane domain-containing protein 7 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CMTM7 Protein Structure

MARVEL

0
100
175 a.a.

Protein Preferred Names	Protein Names
CKLF-like MARVEL transmembrane domain-containing protein 7	chemokine-like factor super family 7

CMTM7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CMTM7	Q96FZ5	SHISA3	Homo sapiens	A0PJX4	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	SHISA3	Homo sapiens	A0PJX4	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	SDC3	Homo sapiens	A0A0S2Z4U3	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	SDC3	Homo sapiens	A0A0S2Z4U3	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	TMEM174	Homo sapiens	Q8WUU8	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	TMEM174	Homo sapiens	Q8WUU8	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	GGT7	Homo sapiens	Q9UJ14	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	GGT7	Homo sapiens	Q9UJ14	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	GGT7	Homo sapiens	Q9UJ14	Validated Y2H	32296183
Intra	CMTM7	Q96FZ5	CLSTN3	Homo sapiens	Q9BQT9	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	CLSTN3	Homo sapiens	Q9BQT9	Validated Y2H	32296183
Intra	CMTM7	Q96FZ5	CLSTN3	Homo sapiens	Q9BQT9	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	HIBADH	Homo sapiens	P31937	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	HIBADH	Homo sapiens	P31937	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	BSCL2	Homo sapiens	J3KQ12	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	BSCL2	Homo sapiens	J3KQ12	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	PIANP	Homo sapiens	Q8IYJ0	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	PIANP	Homo sapiens	Q8IYJ0	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	CD74	Homo sapiens	P04233-2	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	CD74	Homo sapiens	P04233-2	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	DAGLA	Homo sapiens	Q9Y4D2	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	DAGLA	Homo sapiens	Q9Y4D2	Validated Y2H	32296183
Intra	CMTM7	Q96FZ5	DAGLA	Homo sapiens	Q9Y4D2	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	MS4A4A	Homo sapiens	Q96JQ5	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	MS4A4A	Homo sapiens	Q96JQ5	Validated Y2H	32296183
Intra	CMTM7	Q96FZ5	MS4A4A	Homo sapiens	Q96JQ5	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	SLC14A2	Homo sapiens	Q15849	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	SLC14A2	Homo sapiens	Q15849	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	AGER	Homo sapiens	Q15109	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	AGER	Homo sapiens	Q15109	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	HAS3	Homo sapiens	O00219-2	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	HAS3	Homo sapiens	O00219-2	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	CMTM7	Q96FZ5	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	FAM174A	Homo sapiens	Q8TBP5	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	FAM174A	Homo sapiens	Q8TBP5	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	TEX29	Homo sapiens	Q8N6K0	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	TEX29	Homo sapiens	Q8N6K0	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	PAGE1	Homo sapiens	O75459	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	PAGE1	Homo sapiens	O75459	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
Intra	CMTM7	Q96FZ5	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	DNAJC1	Homo sapiens	Q96KC8	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	DNAJC1	Homo sapiens	Q96KC8	Validated Y2H	32296183
Intra	CMTM7	Q96FZ5	DNAJC1	Homo sapiens	Q96KC8	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	B3GAT1	Homo sapiens	Q9P2W7	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	B3GAT1	Homo sapiens	Q9P2W7	Validated Y2H	32296183
Intra	CMTM7	Q96FZ5	B3GAT1	Homo sapiens	Q9P2W7	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	ADTRP	Homo sapiens	Q96IZ2	Validated Y2H	32296183
Intra	CMTM7	Q96FZ5	ADTRP	Homo sapiens	Q96IZ2	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	ADTRP	Homo sapiens	Q96IZ2	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	TNFRSF17	Homo sapiens	Q02223	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	TNFRSF17	Homo sapiens	Q02223	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	TCTA	Homo sapiens	P57738	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	TCTA	Homo sapiens	P57738	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	CMTM7	Q96FZ5	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	FRMD3	Homo sapiens	A2A2Y4	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	FRMD3	Homo sapiens	A2A2Y4	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	THAP4	Homo sapiens	Q8WY91	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	THAP4	Homo sapiens	Q8WY91	Y2H Array	32296183
Intra	CMTM7	Q96FZ5	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	CMTM7	Q96FZ5	CD79A	Homo sapiens	P11912	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mayer-Rokitansky-Kuster-Hauser Syndrome Type 1	Rokitansky Sequence Congenital Absence Of Uterus And Vagina Mrkh Syndrome Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02869	CMTM7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CMTM7	VGNC	VGNC:61003
Canis familiaris	CMTM7	VGNC	VGNC:52872
Mus musculus	CMTM7	MGD	MGI:2447166
Macaca mulatta	CMTM7	VGNC	VGNC:71218
Rattus norvegicus	CMTM7	RGD	RGD:1591926
Bos taurus	CMTM7	VGNC	VGNC:27487
Others	CMTM7	NCBI