SHISA3 - shisa family member 3 Gene

Also Known as hShisa3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 152573

About SHISA3

Cytogenetic location: 4p13 Genomic coordinates (GRCh38): 4:42,397,488-42,402,487 (from NCBI)

This gene has 1 transcript (splice variant), 191 orthologues and 5 paralogues. Biased expression in kidney (RPKM 14.3), lymph node (RPKM 4.2) and 12 other tissues.

Summary

This gene encodes a single-transmembrane protein which is one of nine members of a family of transmembrane adaptors that modulate both Wnt and FGF signaling by blocking the maturation and transport of their receptors to the cell surface. Members of this family contain an N-terminal cysteine-rich domain with a distinct cysteine pattern, a single transmembrane domain, and a C-terminal proline-rich, low complexity region. The encoded protein acts as a tumor suppressor by accelerating beta-catenin degradation. [provided by RefSeq, Jul 2017]

SHISA3 Products (1)

mRNA Protein Name
NM_001080505.3 NP_001073974.1 protein shisa-3 homolog precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHISA3 Protein Structure

Shisa

Shisa: Wnt and FGF inhibitory regulator (23 - 196)

  • 0
  • 100
  • 200
  • 238 a.a.
Protein Preferred Names Protein Names

protein shisa-3 homolog

  • shisa homolog 3

SHISA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SHISA3 A0PJX4 ANKRD46 Homo sapiens Q86W74-2
Validated Y2H
32296183
Intra
SHISA3 A0PJX4 CLDN11 Homo sapiens O75508
Validated Y2H
32296183
Intra
SHISA3 A0PJX4 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
SHISA3 A0PJX4 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
SHISA3 A0PJX4 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
SHISA3 A0PJX4 CMTM7 Homo sapiens Q96FZ5
Validated Y2H
32296183
Intra
SHISA3 A0PJX4 PNMA1 Homo sapiens Q8ND90
Validated Y2H
25416956
Intra
SHISA3 A0PJX4 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
25416956
Intra
SHISA3 A0PJX4 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra
SHISA3 A0PJX4 MAL Homo sapiens P21145
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12867 SHISA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SHISA3 VGNC VGNC:34599
Rattus norvegicus SHISA3 RGD RGD:1565710
Mus musculus SHISA3 MGD MGI:3041225
Felis catus SHISA3 VGNC VGNC:107465
Macaca mulatta SHISA3 VGNC VGNC:107197
Others SHISA3 NCBI