MS4A4A - membrane spanning 4-domains A4A Gene

Homo sapiens

Also known as MS4A4; MS4A7; 4SPAN1; CD20L1; CD20-L1; HDCME31P

Gene ID: 51338 | Gene type: protein coding

About MS4A4A

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,280,666-60,308,970 (from NCBI)

This gene has 18 transcripts (splice variants), 118 orthologues and 16 paralogues. Broad expression in placenta (RPKM 28.4), gall bladder (RPKM 18.9) and 20 other tissues.

Summary

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

MS4A4A Products(3)

mRNA	Protein	Name
NM_001243266.2	NP_001230195.1	membrane-spanning 4-domains subfamily A member 4A isoform 3
NM_024021.4	NP_076926.2	membrane-spanning 4-domains subfamily A member 4A isoform 2
NM_148975.3	NP_683876.1	membrane-spanning 4-domains subfamily A member 4A isoform 1

MS4A4A Protein Structure

CD20

0
100
200
239 a.a.

Protein Preferred Names

Protein Names

membrane-spanning 4-domains subfamily A member 4A

CD20 antigen-like 1

Related Diseases

Diseases

Alias

Alzheimer Disease 4

AD4	Alzheimer Disease-4
Alzheimer'S Disease 4	Alzheimer Disease, Familial, 4
Alzheimer Disease, Familial4	Alzheimer'S Disease 4, Early Onset
Alzheimer Disease, Type 4

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

Uterine Corpus Cancer

Corpus Uteri Cancer

Malignant Uterine Corpus Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08702	MS4A4A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MS4A4A	VGNC	VGNC:104706
Rattus norvegicus	MS4A4A	RGD	RGD:1307006
Mus musculus	MS4A4A	MGD	MGI:3643932

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