MS4A4A - membrane spanning 4-domains A4A Gene

Also Known as MS4A4; MS4A7; 4SPAN1; CD20L1; CD20-L1; HDCME31P

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51338

About MS4A4A

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,280,666-60,308,970 (from NCBI)

This gene has 18 transcripts (splice variants), 118 orthologues and 16 paralogues. Broad expression in placenta (RPKM 28.4), gall bladder (RPKM 18.9) and 20 other tissues.

Summary

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

MS4A4A Products (3)

mRNA Protein Name
NM_001243266.2 NP_001230195.1 membrane-spanning 4-domains subfamily A member 4A isoform 3
NM_024021.4 NP_076926.2 membrane-spanning 4-domains subfamily A member 4A isoform 2
NM_148975.3 NP_683876.1 membrane-spanning 4-domains subfamily A member 4A isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30833792 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
31413141 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
31413141 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
23874341 GOA
located in plasma membrane raft IDA
IDA: Inferred from direct assay
31413141 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MS4A4A Protein Structure

CD20

CD20: CD20-like family (65 - 207)

  • 0
  • 100
  • 200
  • 239 a.a.
Protein Preferred Names Protein Names

membrane-spanning 4-domains subfamily A member 4A

  • CD20 antigen-like 1

MS4A4A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MS4A4A Q96JQ5 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
MS4A4A Q96JQ5 RPRM Homo sapiens Q9NS64
Complementation
32296183
Intra
MS4A4A Q96JQ5 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra
MS4A4A Q96JQ5 NRG1 Homo sapiens Q02297-10
Y2H Array
32296183
Intra
MS4A4A Q96JQ5 NRG1 Homo sapiens Q02297-10
Y2H Prey Pooling
32296183
Intra
MS4A4A Q96JQ5 ATP6V0E1 Homo sapiens O15342
Y2H Prey Pooling
32296183
Intra
MS4A4A Q96JQ5 ATP6V0E1 Homo sapiens O15342
Y2H Array
32296183
Intra
MS4A4A Q96JQ5 CSE1L Homo sapiens P55060
Pull Down
30833792
Intra
MS4A4A Q96JQ5 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
MS4A4A Q96JQ5 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
MS4A4A Q96JQ5 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
MS4A4A Q96JQ5 SEC22A Homo sapiens Q96IW7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Alzheimer Disease 4

  • AD4

  • Alzheimer Disease-4

  • Alzheimer'S Disease 4

  • Alzheimer Disease, Familial, 4

  • Alzheimer Disease, Familial4

  • Alzheimer'S Disease 4, Early Onset

  • Alzheimer Disease, Type 4
Chromophobe Renal Cell Carcinoma

  • Chromophobe Adenocarcinoma

  • Chromophobe Carcinoma Of Kidney

  • Kidney Chromophobe

  • Renal Cell Carcinoma, Chromophobe Cell

  • Crcc

  • Chrcc

  • Chromophobe Renal Cell Adenocarcinoma

  • Chromophobe Renal Carcinoma

  • Chromophobe Carcinoma
Uterine Corpus Cancer

  • Corpus Uteri Cancer

  • Malignant Uterine Corpus Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08702 MS4A4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MS4A4A VGNC VGNC:104706
Rattus norvegicus MS4A4A RGD RGD:1307006
Mus musculus MS4A4A MGD MGI:3643932
Others MS4A4A NCBI