2. Gene
  3. CSE1L - chromosome segregation 1 like Gene

CSE1L - chromosome segregation 1 like Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAS; CSE1; XPO2

Gene ID: 1434 | Gene type: protein coding

About CSE1L

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,046,312-49,096,949 (from NCBI)

This gene has 3 transcripts (splice variants), 212 orthologues and 4 paralogues. Broad expression in testis (RPKM 57.6), esophagus (RPKM 21.5) and 24 other tissues.

Summary

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in Apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

CSE1L Products(3)

mRNA Protein Name
NM_001256135.2 NP_001243064.1 exportin-2 isoform 2
NM_001316.4 NP_001307.2 exportin-2 isoform 1
NM_001362762.2 NP_001349691.1 exportin-2 isoform 3

CSE1L Protein Structure

IBN_N

IBN_N: Importin-beta N-terminal domain (29 - 101)

Cse1

Cse1: Cse1 (156 - 525)

CAS_CSE1

CAS_CSE1: CAS/CSE protein, C-terminus (527 - 962)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 971 a.a.
Protein Preferred Names Protein Names

exportin-2

CSE1 chromosome segregation 1-like

Related Diseases

Diseases Alias
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03226 CSE1L Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CSE1L RGD RGD:1307536
Felis catus CSE1L VGNC VGNC:80076
Bos taurus CSE1L VGNC VGNC:27752
Macaca mulatta CSE1L VGNC VGNC:71512
Canis familiaris CSE1L VGNC VGNC:39651
Mus musculus CSE1L MGD MGI:1339951