P2RY6 - pyrimidinergic receptor P2Y6 Gene

Also Known as P2Y6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5031

About P2RY6

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:73,264,506-73,298,625 (from NCBI)

This gene has 16 transcripts (splice variants), 183 orthologues and 15 paralogues. Biased expression in spleen (RPKM 4.4), placenta (RPKM 2.2) and 9 other tissues.

Summary

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

P2RY6 Products (17)

mRNA Protein Name
XM_047427039.1 XP_047282995.1 P2Y purinoceptor 6 isoform X3
XM_047427037.1 XP_047282993.1 P2Y purinoceptor 6 isoform X3
NM_176797.3 NP_789767.1 P2Y purinoceptor 6 isoform 1
XM_011545076.3 XP_011543378.1 P2Y purinoceptor 6 isoform X1
XM_005274022.4 XP_005274079.1 P2Y purinoceptor 6 isoform X3
NM_001277206.2 NP_001264135.1 P2Y purinoceptor 6 isoform 1
XM_011545079.3 XP_011543381.1 P2Y purinoceptor 6 isoform X3
NM_001277208.1 NP_001264137.1 P2Y purinoceptor 6 isoform 2
NM_001277204.2 NP_001264133.1 P2Y purinoceptor 6 isoform 1
NM_176796.3 NP_789766.1 P2Y purinoceptor 6 isoform 1
XM_047427036.1 XP_047282992.1 P2Y purinoceptor 6 isoform X2
NM_001277207.2 NP_001264136.1 P2Y purinoceptor 6 isoform 1
XM_006718571.4 XP_006718634.1 P2Y purinoceptor 6 isoform X3
XM_047427038.1 XP_047282994.1 P2Y purinoceptor 6 isoform X3
NM_001277205.2 NP_001264134.1 P2Y purinoceptor 6 isoform 1
NM_004154.3
NM_176798.2 NP_789768.1 P2Y purinoceptor 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled ADP receptor activity IDA
IDA: Inferred from direct assay
8670200 GOA
enables G protein-coupled UDP receptor activity IDA
IDA: Inferred from direct assay
8670200 GOA
enables G protein-coupled UTP receptor activity IDA
IDA: Inferred from direct assay
8670200 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to purine-containing compound IDA
IDA: Inferred from direct assay
8670200 GOA
involved in cellular response to pyrimidine ribonucleotide IDA
IDA: Inferred from direct assay
8670200 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
28277742 GOA
involved in positive regulation of inositol trisphosphate biosynthetic process IDA
IDA: Inferred from direct assay
8670200 GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
28277742 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RY6 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (44 - 300)

  • 0
  • 100
  • 200
  • 300
  • 328 a.a.
Protein Preferred Names Protein Names

P2Y purinoceptor 6

  • G-coupled nucleotide receptor

  • P2 purinoceptor

  • P2Y6 receptor

  • pyrimidinergic receptor P2Y, G-protein coupled, 6

P2RY6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
P2RY6 Q15077 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
P2RY6 Q15077 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
P2RY6 Q15077 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
32296183
Intra
P2RY6 Q15077 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
Intra
P2RY6 Q15077 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
32296183
Intra
P2RY6 Q15077 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
P2RY6 Q15077 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
P2RY6 Q15077 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
P2RY6 Q15077 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
P2RY6 Q15077 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
P2RY6 Q15077 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra
P2RY6 Q15077 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
P2RY6 Q15077 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
P2RY6 Q15077 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
P2RY6 Q15077 MCFD2 Homo sapiens Q8NI22
Validated Y2H
32296183
Intra
P2RY6 Q15077 CSE1L Homo sapiens P55060
Pull Down
30833792
Intra
P2RY6 Q15077 KPNB1 Homo sapiens Q14974
Pull Down
30833792
Intra
P2RY6 Q15077 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra
P2RY6 Q15077 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra
P2RY6 Q15077 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra
P2RY6 Q15077 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
P2RY6 Q15077 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
P2RY6 Q15077 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
P2RY6 Q15077 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
P2RY6 Q15077 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
P2RY6 Q15077 PLSCR1 Homo sapiens O15162
Validated Y2H
25416956
Intra
P2RY6 Q15077 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
P2RY6 Q15077 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

P2RY6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81946 P2Y6 Antibody (YA1691) WB, IHC-F, IHC-P, ICC/IF, IP Human
HY-P81946A P2Y6 Antibody (YA1691)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human

Related Diseases

Diseases Alias
Cataract 4, Multiple Types

  • Cataract 4 Multiple Types

  • CTRCT4

  • Cca3

  • Pcc

  • Aculeiform Cataract

  • Cataract 4, Multiple Types, With Or Without Microcornea

  • Cataract, Crystalline Aculeiform

  • Caca

  • Cataract, Congenital, Cerulean Type, 3

  • Congenital Cataract Cerulean Type 3

  • Cataract Congenital Dominant Non Nuclear

  • Ccp

  • Cataract, Nonnuclear Polymorphic Congenital

  • Cataract, Punctate, Progressive Juvenile-Onset

  • Cataract 4 Multiple Types With Or Without Microcornea

  • Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

  • Cataract, Polymorphic Congenital

  • Congenital Cataract Blue Dot Type 3

  • Congenital Non-Nuclear Polymorphic Cataract

  • Crystalline Aculeiform Cataract

  • Punctate, Progressive Juvenile-Onset, Cataract

  • Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09934 P2RY6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09935 P2ry6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09936 P2ry6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus P2RY6 RGD RGD:620269
Canis familiaris P2RY6 VGNC VGNC:44218
Bos taurus P2RY6 VGNC VGNC:32530
Mus musculus P2RY6 MGD MGI:2673874
Macaca mulatta P2RY6 VGNC VGNC:75740
Felis catus P2RY6 VGNC VGNC:81964
Others P2RY6 NCBI