2. Gene
  3. P2RY6 - pyrimidinergic receptor P2Y6 Gene

P2RY6 - pyrimidinergic receptor P2Y6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P2Y6

Gene ID: 5031 | Gene type: protein coding

About P2RY6

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:73,264,506-73,298,625 (from NCBI)

This gene has 16 transcripts (splice variants), 183 orthologues and 15 paralogues. Biased expression in spleen (RPKM 4.4), placenta (RPKM 2.2) and 9 other tissues.

Summary

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

P2RY6 Products(17)

mRNA Protein Name
XM_047427039.1 XP_047282995.1 P2Y purinoceptor 6 isoform X3
XM_047427037.1 XP_047282993.1 P2Y purinoceptor 6 isoform X3
NM_176797.3 NP_789767.1 P2Y purinoceptor 6 isoform 1
XM_011545076.3 XP_011543378.1 P2Y purinoceptor 6 isoform X1
XM_005274022.4 XP_005274079.1 P2Y purinoceptor 6 isoform X3
NM_001277206.2 NP_001264135.1 P2Y purinoceptor 6 isoform 1
XM_011545079.3 XP_011543381.1 P2Y purinoceptor 6 isoform X3
NM_001277208.1 NP_001264137.1 P2Y purinoceptor 6 isoform 2
NM_001277204.2 NP_001264133.1 P2Y purinoceptor 6 isoform 1
NM_176796.3 NP_789766.1 P2Y purinoceptor 6 isoform 1
XM_047427036.1 XP_047282992.1 P2Y purinoceptor 6 isoform X2
NM_001277207.2 NP_001264136.1 P2Y purinoceptor 6 isoform 1
XM_006718571.4 XP_006718634.1 P2Y purinoceptor 6 isoform X3
XM_047427038.1 XP_047282994.1 P2Y purinoceptor 6 isoform X3
NM_001277205.2 NP_001264134.1 P2Y purinoceptor 6 isoform 1
NM_004154.3
NM_176798.2 NP_789768.1 P2Y purinoceptor 6 isoform 1

P2RY6 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (44 - 300)

  • 0
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  • 300
  • 328 a.a.
Protein Preferred Names Protein Names

P2Y purinoceptor 6

G-coupled nucleotide receptor

P2 purinoceptor

P2Y6 receptor

pyrimidinergic receptor P2Y, G-protein coupled, 6

Related Diseases

Diseases Alias
Cataract 4, Multiple Types

Cataract 4 Multiple Types

CTRCT4

Cca3

Pcc

Aculeiform Cataract

Cataract 4, Multiple Types, With Or Without Microcornea

Cataract, Crystalline Aculeiform

Caca

Cataract, Congenital, Cerulean Type, 3

Congenital Cataract Cerulean Type 3

Cataract Congenital Dominant Non Nuclear

Ccp

Cataract, Nonnuclear Polymorphic Congenital

Cataract, Punctate, Progressive Juvenile-Onset

Cataract 4 Multiple Types With Or Without Microcornea

Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

Cataract, Polymorphic Congenital

Congenital Cataract Blue Dot Type 3

Congenital Non-Nuclear Polymorphic Cataract

Crystalline Aculeiform Cataract

Punctate, Progressive Juvenile-Onset, Cataract

Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09934 P2RY6 Human Pre-designed siRNA Set A / Unkown
HY-RS09935 P2ry6 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09936 P2ry6 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus P2RY6 RGD RGD:620269
Canis familiaris P2RY6 VGNC VGNC:44218
Bos taurus P2RY6 VGNC VGNC:32530
Mus musculus P2RY6 MGD MGI:2673874
Macaca mulatta P2RY6 VGNC VGNC:75740
Felis catus P2RY6 VGNC VGNC:81964