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THAP4 - THAP domain containing 4 Gene

Also Known as PP238; CGI-36; Nb(III)

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51078

About THAP4

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,584,405-241,637,576 (from NCBI)

This gene has 5 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in testis (RPKM 14.3), heart (RPKM 13.9) and 25 other tissues.

Summary

Enables several functions, including heme binding activity; identical protein binding activity; and peroxynitrite isomerase activity. Involved in nitrate metabolic process and tyrosine metabolic process. [provided by Alliance of Genome Resources, Apr 2022]

THAP4 Products (2)

mRNA	Protein	Name
NM_001164356.2	NP_001157828.1	peroxynitrite isomerase THAP4 isoform 2
NM_015963.6	NP_057047.4	peroxynitrite isomerase THAP4 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables heme binding	IMP IMP: Inferred from mutant phenotype	21387410	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21387410	GOA
enables nitric oxide binding	IDA IDA: Inferred from direct assay	30524950	GOA
enables peroxynitrite isomerase activity	IDA IDA: Inferred from direct assay	30524950	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in nitrate metabolic process	IDA IDA: Inferred from direct assay	30524950	GOA
involved in tyrosine metabolic process	IDA IDA: Inferred from direct assay	30524950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THAP4 Protein Structure

THAP

DUF1794

0
100
200
300
400
500
577 a.a.

Protein Preferred Names	Protein Names
peroxynitrite isomerase THAP4	THAP domain-containing protein 4

THAP4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	THAP4	Q8WY91	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Prey Pooling	32296183
Intra	THAP4	Q8WY91	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Array	32296183
Intra	THAP4	Q8WY91	TNFRSF10D	Homo sapiens	Q9UBN6	Validated Y2H	32296183
Intra	THAP4	Q8WY91	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	THAP4	Q8WY91	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	THAP4	Q8WY91	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	THAP4	Q8WY91	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	THAP4	Q8WY91	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	THAP4	Q8WY91	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	THAP4	Q8WY91	NDRG4	Homo sapiens	Q9ULP0-2	Validated Y2H	32296183
Intra	THAP4	Q8WY91	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	THAP4	Q8WY91	TPD52	Homo sapiens	P55327-2	Y2H Array	32296183
Intra	THAP4	Q8WY91	TPD52	Homo sapiens	P55327-2	Y2H Prey Pooling	32296183
Intra	THAP4	Q8WY91	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Array	32296183
Intra	THAP4	Q8WY91	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Prey Pooling	32296183
Intra	THAP4	Q8WY91	RMDN2	Homo sapiens	Q96LZ7	Validated Y2H	32296183
Intra	THAP4	Q8WY91	CMTM7	Homo sapiens	Q96FZ5	Validated Y2H	32296183
Intra	THAP4	Q8WY91	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	THAP4	Q8WY91	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	THAP4	Q8WY91	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	THAP4	Q8WY91	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	THAP4	Q8WY91	CPNE2	Homo sapiens	Q96FN4	Anti Tag CoIP	33961781
Intra	THAP4	Q8WY91	CPNE2	Homo sapiens	Q96FN4	Validated Y2H	32296183
Intra	THAP4	Q8WY91	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	THAP4	Q8WY91	BSND	Homo sapiens	Q8WZ55	Y2H Prey Pooling	32296183
Intra	THAP4	Q8WY91	BSND	Homo sapiens	Q8WZ55	Validated Y2H	32296183
Intra	THAP4	Q8WY91	BSND	Homo sapiens	Q8WZ55	Y2H Array	32296183
Intra	THAP4	Q8WY91	SYP	Homo sapiens	P08247	Y2H Array	32296183
Intra	THAP4	Q8WY91	SYP	Homo sapiens	P08247	Y2H Prey Pooling	32296183
Intra	THAP4	Q8WY91	MAL2	Homo sapiens	Q969L2	Y2H Prey Pooling	32296183
Intra	THAP4	Q8WY91	MAL2	Homo sapiens	Q969L2	Y2H Array	32296183
Intra	THAP4	Q8WY91	MAL2	Homo sapiens	Q969L2	Validated Y2H	32296183
Intra	THAP4	Q8WY91	SCAMP1	Homo sapiens	O15126	Y2H Array	32296183
Intra	THAP4	Q8WY91	SCAMP1	Homo sapiens	O15126	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Venous Hemangioma
Chromosome 2q37 Deletion Syndrome	Albright Hereditary Osteodystrophy-Like Syndrome 2q37 Microdeletion Syndrome Brachydactyly-Intellectual Disability Syndrome Deletion 2q37 2q37 Deletion Syndrome Brachydactyly-Mental Retardation Syndrome Bdmr Albright Hereditary Osteodystrophy Type 3 Del(2)(Q37) Monosomy 2q37qter Albright'S Hereditary Osteodystrophy-Like Syndrome Monosomy 2q37 Chromosome Deletion Syndrome 2q37

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14475	THAP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	THAP4	VGNC	VGNC:99410
Mus musculus	THAP4	MGD	MGI:1914276
Felis catus	THAP4	VGNC	VGNC:80379
Rattus norvegicus	THAP4	RGD	RGD:1359473
Canis familiaris	THAP4	VGNC	VGNC:59098
Bos taurus	THAP4	VGNC	VGNC:55691
Others	THAP4	NCBI