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CPNE2 - copine 2 Gene

Also Known as CPN2; COPN2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 221184

About CPNE2

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:57,092,583-57,148,369 (from NCBI)

This gene has 10 transcripts (splice variants), 217 orthologues and 8 paralogues. Ubiquitous expression in lung (RPKM 25.9), fat (RPKM 23.8) and 24 other tissues.

Summary

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an Integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]

CPNE2 Products (1)

mRNA	Protein	Name
NM_152727.6	NP_689940.3	copine-2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPNE2 Protein Structure

Copine

0
100
200
300
400
500
548 a.a.

Protein Preferred Names	Protein Names
copine-2	copine II

CPNE2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CPNE2	Q96FN4	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	CPNE2	Q96FN4	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	CPNE2	Q96FN4	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Prey Pooling	32296183
Intra	CPNE2	Q96FN4	NCKIPSD	Homo sapiens	Q9NZQ3-3	Validated Y2H	32296183
Intra	CPNE2	Q96FN4	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Array	32296183
Intra	CPNE2	Q96FN4	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	CPNE2	Q96FN4	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	CPNE2	Q96FN4	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CPNE2	Q96FN4	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CPNE2	Q96FN4	MEI4	Homo sapiens	A8MW99	Y2H Prey Pooling	32296183
Intra	CPNE2	Q96FN4	MEI4	Homo sapiens	A8MW99	Y2H Array	32296183
Intra	CPNE2	Q96FN4	GBP7	Homo sapiens	Q8N8V2	Y2H Prey Pooling	32296183
Intra	CPNE2	Q96FN4	GBP7	Homo sapiens	Q8N8V2	Y2H Array	32296183
Intra	CPNE2	Q96FN4	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	CPNE2	Q96FN4	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	CPNE2	Q96FN4	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	CPNE2	Q96FN4	CT55	Homo sapiens	Q8WUE5	Y2H Prey Pooling	32296183
Intra	CPNE2	Q96FN4	CT55	Homo sapiens	Q8WUE5	Y2H Array	32296183
Intra	CPNE2	Q96FN4	KATNBL1	Homo sapiens	Q9H079	Y2H Prey Pooling	32296183
Intra	CPNE2	Q96FN4	KATNBL1	Homo sapiens	Q9H079	Validated Y2H	32296183
Intra	CPNE2	Q96FN4	KATNBL1	Homo sapiens	Q9H079	Y2H Array	32296183
Intra	CPNE2	Q96FN4	UBA3	Homo sapiens	Q8TBC4	Y2H Prey Pooling	25416956
Intra	CPNE2	Q96FN4	UBA3	Homo sapiens	Q8TBC4	Y2H Prey Pooling	32296183
Intra	CPNE2	Q96FN4	UBA3	Homo sapiens	Q8TBC4	Y2H Array	32296183
Intra	CPNE2	Q96FN4	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	CPNE2	Q96FN4	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	CPNE2	Q96FN4	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	CPNE2	Q96FN4	THAP4	Homo sapiens	Q8WY91	Y2H Array	32296183
Intra	CPNE2	Q96FN4	THAP4	Homo sapiens	Q8WY91	Y2H Prey Pooling	32296183
Intra	CPNE2	Q96FN4	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	CPNE2	Q96FN4	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	CPNE2	Q96FN4	SORBS3	Homo sapiens	O60504	Y2H Array	25416956
Intra	CPNE2	Q96FN4	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	CPNE2	Q96FN4	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
Intra	CPNE2	Q96FN4	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950
Intra	CPNE2	Q96FN4	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	CPNE2	Q96FN4	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	CPNE2	Q96FN4	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03104	CPNE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26220	Nlrc5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CPNE2	MGD	MGI:2387578
Bos taurus	CPNE2	VGNC	VGNC:27659
Macaca mulatta	CPNE2	VGNC	VGNC:71464
Rattus norvegicus	CPNE2	RGD	RGD:1586036
Canis familiaris	CPNE2	VGNC	VGNC:39561
Felis catus	CPNE2	VGNC	VGNC:61129
Others	CPNE2	NCBI