SYP - synaptophysin Gene
Also Known as MRX96; MRXSYP; XLID96
Species: Homo sapiens
About SYP
This gene has 11 transcripts (splice variants), 263 orthologues, 3 paralogues and is associated with 3 phenotypes. Biased expression in brain (RPKM 226.8) and adrenal (RPKM 21.1).
Summary
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds Cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]
SYP Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_003179.3 | NP_003170.1 | synaptophysin |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables cholesterol binding |
IDA
IDA: Inferred from direct assay
|
10620806 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
17500595 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in neuron projection |
IDA
IDA: Inferred from direct assay
|
8838578 | GOA |
SYP Protein Structure
MARVEL: Membrane-associating domain (22 - 221)
- 0
- 100
- 200
- 313 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
synaptophysin |
|
SYP Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SYP | P08247 | PNKP | Homo sapiens | Q96T60 | 32296183 | |
|
Intra
|
SYP | P08247 | LNPK | Homo sapiens | Q9C0E8-2 | 32296183 | |
|
Intra
|
SYP | P08247 | NDRG4 | Homo sapiens | Q9ULP0-2 | 32296183 | |
|
Intra
|
SYP | P08247 | MIEF2 | Homo sapiens | Q96C03-3 | 32296183 | |
|
Intra
|
SYP | P08247 | WIPI2 | Homo sapiens | Q9Y4P8-4 | 32296183 | |
|
Intra
|
SYP | P08247 | JOSD2 | Homo sapiens | Q8TAC2 | 32296183 | |
|
Intra
|
SYP | P08247 | GDNF | Homo sapiens | P39905-3 | 32296183 | |
|
Intra
|
SYP | P08247 | GDNF | Homo sapiens | P39905-3 | 32296183 | |
|
Intra
|
SYP | P08247 | PITPNC1 | Homo sapiens | Q9UKF7-2 | 32296183 | |
|
Intra
|
SYP | P08247 | STARD4 | Homo sapiens | Q96DR4 | 32296183 | |
|
Intra
|
SYP | P08247 | LAMP2 | Homo sapiens | P13473-2 | 32814053 | |
|
Intra
|
SYP | P08247 | LAMP2 | Homo sapiens | P13473-2 | 32814053 | |
|
Intra
|
SYP | P08247 | LAMP2 | Homo sapiens | P13473-2 | 32814053 | |
|
Intra
|
SYP | P08247 | SH3GLB1 | Homo sapiens | Q9Y371 | 32814053 | |
|
Intra
|
SYP | P08247 | SH3GLB1 | Homo sapiens | Q9Y371 | 32814053 | |
|
Intra
|
SYP | P08247 | SH3GLB1 | Homo sapiens | Q9Y371 | 32814053 | |
|
Intra
|
SYP | P08247 | SH3GLB1 | Homo sapiens | Q9Y371 | 32296183 | |
|
Intra
|
SYP | P08247 | SNX1 | Homo sapiens | Q13596 | 32296183 | |
|
Intra
|
SYP | P08247 | MRRF | Homo sapiens | Q96E11 | 32296183 | |
|
Intra
|
SYP | P08247 | SMG9 | Homo sapiens | Q9H0W8 | 32296183 | |
|
Intra
|
SYP | P08247 | RBFA | Homo sapiens | Q8N0V3 | 32296183 | |
|
Intra
|
SYP | P08247 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
SYP | P08247 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
SYP | P08247 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
SYP | P08247 | DIABLO | Homo sapiens | Q9NR28 | 32296183 | |
|
Intra
|
SYP | P08247 | MRM1 | Homo sapiens | Q6IN84 | 32296183 | |
|
Intra
|
SYP | P08247 | PPIF | Homo sapiens | P30405 | 32296183 | |
|
Intra
|
SYP | P08247 | ARFIP2 | Homo sapiens | P53365 | 32296183 | |
|
Intra
|
SYP | P08247 | MYG1 | Homo sapiens | Q9HB07 | 32296183 | |
|
Intra
|
SYP | P08247 | TUBB2A | Homo sapiens | Q13885 | 32814053 | |
|
Intra
|
SYP | P08247 | TUBB2A | Homo sapiens | Q13885 | 32814053 | |
|
Intra
|
SYP | P08247 | TUBB2A | Homo sapiens | Q13885 | 32814053 | |
|
Intra
|
SYP | P08247 | THAP4 | Homo sapiens | Q8WY91 | 32296183 | |
|
Intra
|
SYP | P08247 | MIEF1 | Homo sapiens | Q9NQG6 | 32296183 | |
|
Intra
|
SYP | P08247 | PBX3 | Homo sapiens | Q96AL5 | 32296183 | |
|
Intra
|
SYP | P08247 | SPG21 | Homo sapiens | Q9NZD8 | 32296183 | |
|
Intra
|
SYP | P08247 | PTPN9 | Homo sapiens | P43378 | 32296183 | |
|
Intra
|
SYP | P08247 | MTERF3 | Homo sapiens | Q96E29 | 32296183 | |
|
Intra
|
SYP | P08247 | HSFX1 | Homo sapiens | Q9UBD0 | 32296183 | |
|
Intra
|
SYP | P08247 | WDFY2 | Homo sapiens | Q96P53 | 32296183 |
SYP Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80354 | Synaptophysin Antibody (YA043) | WB, IHC-P | Human, Mouse, Rat |
| HY-P80907 | Synaptophysin Antibody (YA664) | WB, IHC-P | Human, Mouse, Rat |
| HY-P84005 | Synaptophysin Antibody (YA3702) | WB, IHC-P, ELISA | Human, Rat |
| HY-P84005A | Synaptophysin Antibody (YA3702)(PBS only) | WB, IHC-P, ELISA | Human, Rat |
| HY-P86110 | Synaptophysin Antibody (YA5802) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Intellectual Developmental Disorder, X-Linked 96 |
|
|
| Non-Syndromic X-Linked Intellectual Disability |
|
|
| Central Neurocytoma |
|
|
| Neuroendocrine Carcinoma |
|
|
| Olfactory Neuroblastoma |
|
|
| Ganglioneuroma |
|
|
| Merkel Cell Carcinoma |
|
|
| Adrenal Cortical Adenoma |
|
|
| Subependymal Giant Cell Astrocytoma |
|
|
| Ganglioglioma |
|
|
| Large Cell Carcinoma |
|
|
| Endocrine Gland Cancer |
|
|
| Binswanger'S Disease |
|
|
| Sertoli Cell Tumor |
|
|
| Neuroendocrine Tumor |
|
|
| Pulmonary Sclerosing Hemangioma |
|
|
| Sclerosing Hemangioma |
|
|
| Paraganglioma |
|
|
| Pineoblastoma |
|
|
| Glomus Tumor |
|
|
| Large Cell Neuroendocrine Carcinoma |
|
|
| Rhabdoid Cancer |
|
|
| Blastoma |
|
|
| Malignant Olfactory Nerve Neoplasm |
|
|
| Nasal Cavity Cancer |
|
|
| Ganglioneuroblastoma |
|
|
| Hemangioblastoma |
|
|
| Pineocytoma |
|
|
| Middle Ear Adenoma |
|
|
| Auditory System Benign Neoplasm |
|
|
| Neurofibroma |
|
|
| Oligodendroglioma |
|
|
| Breast Neuroendocrine Neoplasm |
|
|
| Sensory Organ Benign Neoplasm |
|
|
| Pulmonary Large Cell Neuroendocrine Carcinoma |
|
|
| Cerebral Neuroblastoma |
|
|
| Papillary Ependymoma |
|
|
| Pulmonary Blastoma |
|
|
| Lung Large Cell Carcinoma |
|
|
| Esophageal Neuroendocrine Tumor |
|
|
| Urinary Bladder Small Cell Neuroendocrine Carcinoma |
|
|
| Benign Teratoma |
|
|
| Ampulla Of Vater Benign Neoplasm |
|
|
| Ureter Small Cell Carcinoma |
|
|
| Papilloma Of Choroid Plexus |
|
|
| Duodenal Benign Neoplasm |
|
|
| Ovarian Large-Cell Neuroendocrine Carcinoma |
|
|
| Bladder Small Cell Carcinoma |
|
|
| Tuberous Sclerosis |
|
|
| Cranial Nerve Malignant Neoplasm |
|
|
| Cellular Ependymoma |
|
|
| Ovarian Mucinous Adenofibroma |
|
|
| Ovarian Mucinous Cystadenofibroma |
|
|
| Sertoli-Leydig Cell Tumor |
|
|
| Sweat Gland Cancer |
|
|
| Pheochromocytoma |
|
|
| Pineal Gland Cancer |
|
|
| Basaloid Squamous Cell Carcinoma |
|
|
| Melanotic Neuroectodermal Tumor |
|
|
| Pulmonary Neuroendocrine Tumor |
|
|
| Thymic Carcinoma |
|
|
| Supratentorial Cancer |
|
|
| Cerebrum Cancer |
|
|
| Cerebellar Liponeurocytoma |
|
|
| Islet Cell Tumor |
|
|
| Medullomyoblastoma |
|
|
| Breast Papillary Carcinoma |
|
|
| Pineal Parenchymal Tumor Of Intermediate Differentiation |
|
|
| Auditory System Cancer |
|
|
| Carcinoid Tumors, Intestinal |
|
|
| Small Cell Cancer Of The Lung |
|
|
| Mixed Ductal-Endocrine Carcinoma |
|
|
| Carotid Body Cancer |
|
|
| Gangliocytoma |
|
|
| Gastrointestinal Neuroendocrine Tumor |
|
|
| Obstructive Hydrocephalus |
|
|
| Endometrial Small Cell Carcinoma |
|
|
| Sinonasal Undifferentiated Carcinoma |
|
|
| Pancreatoblastoma |
|
|
| Cauda Equina Neoplasm |
|
|
| Cerebral Ventricle Cancer |
|
|
| Paranasal Sinus Cancer |
|
|
| Gallbladder Small Cell Carcinoma |
|
|
| Colon Neuroendocrine Neoplasm |
|
|
| Creutzfeldt-Jakob Disease |
|
|
| Cystadenoma |
|
|
| Gastric Small Cell Carcinoma |
|
|
| Spinal Muscular Atrophy, Type I |
|
|
| Acinar Cell Cystadenocarcinoma |
|
|
| Leydig Cell Tumor |
|
|
| Adrenal Carcinoma |
|
|
| Lung Benign Neoplasm |
|
|
| Cervix Small Cell Carcinoma |
|
|
| Medulloblastoma |
|
|
| Pancreatic Acinar Cell Adenocarcinoma |
|
|
| Appendix Carcinoid Tumor |
|
|
| Medulloepithelioma |
|
|
| Granular Cell Tumor |
|
|
| Mediastinal Cancer |
|
|
| Glomangiosarcoma |
|
|
| Pilocytic Astrocytoma |
|
|
| Peripheral Nervous System Benign Neoplasm |
|
|
| Autonomic Nervous System Benign Neoplasm |
|
|
| Teratoma |
|
|
| Amyloidosis |
|
|
| Tubular Adenocarcinoma |
|
|
| Adrenal Neuroblastoma |
|
|
| Cerebrovascular Benign Neoplasm |
|
|
| Benign Perivascular Tumor |
|
|
| Ovarian Germ Cell Teratoma |
|
|
| Central Nervous System Primitive Neuroectodermal Neoplasm |
|
|
| Glomangioma |
|
|
| Malignant Melanocytic Neoplasm Of The Peripheral Nerve Sheath |
|
|
| Adenoma |
|
|
| Glomangiomyoma |
|
|
| Gastrointestinal Neuroendocrine Benign Tumor |
|
|
| Gastrinoma |
|
|
| Multiple Endocrine Neoplasia |
|
|
| Spinal Cord Oligodendroglioma |
|
|
| Extraosseous Ewing Sarcoma |
|
|
| Conn'S Syndrome |
|
|
| Ovary Neuroendocrine Neoplasm |
|
|
| Laryngeal Small Cell Carcinoma |
|
|
| Choroid Plexus Cancer |
|
|
| Dysembryoplastic Neuroepithelial Tumor |
|
|
| Chordoid Meningioma |
|
|
| Carcinosarcoma |
|
|
| Vagus Nerve Neoplasm |
|
|
| Anal Neuroendocrine Tumor |
|
|
| Hemangioma |
|
|
| Adrenal Cortical Carcinoma |
|
|
| Thymus Small Cell Carcinoma |
|
|
| Small Cell Carcinoma |
|
|
| Prostate Neuroendocrine Neoplasm |
|
|
| Intestinal Pseudo-Obstruction |
|
|
| Cystic Teratoma |
|
|
| Neuronal Intestinal Dysplasia, Type B |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Cerebellum Cancer |
|
|
| Lung Cancer |
|
|
| Supratentorial Primitive Neuroectodermal Tumor |
|
|
| Glomangiomatosis |
|
|
| Askin'S Tumor |
|
|
| Clear Cell Ependymoma |
|
|
| Brain Cancer |
|
|
| Microcystic Adenoma |
|
|
| Adrenogenital Syndrome |
|
|
| Gastric Neuroendocrine Neoplasm |
|
|
| Mucinous Adenofibroma |
|
|
| Cervical Large Cell Neuroendocrine Carcinoma |
|
|
| Cloacogenic Carcinoma |
|
|
| Myocardium Cancer |
|
|
| Embryonal Tumor With Multilayered Rosettes, C19mc-Altered |
|
|
| Hirschsprung Disease 1 |
|
|
| Laryngeal Neuroendocrine Tumor |
|
|
| Papillary Squamous Carcinoma |
|
|
| Chiari Malformation |
|
|
| Dementia |
|
|
| Extra-Adrenal Pheochromocytoma |
|
|
| Perivascular Tumor |
|
|
| Carcinoid Syndrome |
|
|
| Hydrocephalus |
|
|
| Malignant Teratoma |
|
|
| Lung Meningioma |
|
|
| Oncocytoma |
|
|
| Extraosseous Chondrosarcoma |
|
|
| Partial Cryptophthalmia |
|
|
| Jejunal Neoplasm |
|
|
| Rhabdoid Meningioma |
|
|
| Small Intestine Benign Neoplasm |
|
|
| Benign Ependymoma |
|
|
| Ectomesenchymoma |
|
|
| Thymoma |
|
|
| Krukenberg Carcinoma |
|
|
| Central Nervous System Mesenchymal Non-Meningothelial Tumor |
|
|
| Nodular Ganglioneuroblastoma |
|
|
| Motor Neuron Disease |
|
|
| Malignant Pheochromocytoma |
|
|
| Atypical Teratoid Rhabdoid Tumor |
|
|
| Adrenal Medulla Cancer |
|
|
| Meningioma, Familial |
|
|
| Lung Oat Cell Carcinoma |
|
|
| Mixed Cell Type Cancer |
|
|
| Clear Cell Meningioma |
|
|
| Anal Paget'S Disease |
|
|
| Breast Ductal Carcinoma |
|
|
| Inner Ear Disease |
|
|
| Intracranial Primitive Neuroectodermal Tumor |
|
|
| Retinoblastoma |
|
|
| Insulinoma |
|
|
| Chondrosarcoma, Extraskeletal Myxoid |
|
|
| Ovarian Germ Cell Cancer |
|
|
| Lymphoepithelioma-Like Carcinoma |
|
|
| Keratinizing Squamous Cell Carcinoma |
|
|
| Pancreatic Gastrinoma |
|
|
| Appendix Adenocarcinoma |
|
|
| Mature Teratoma Of The Ovary |
|
|
| Ovarian Small Cell Carcinoma |
|
|
| Cerebellar Hypoplasia |
|
|
| Pancreatic Endocrine Carcinoma |
|
|
| Mature Teratoma |
|
|
| Thyroid Gland Cancer |
|
|
| Attention Deficit-Hyperactivity Disorder |
|
|
| Vulvar Eccrine Porocarcinoma |
|
|
| Desmoplastic Small Round Cell Tumor |
|
|
| Thymus Basaloid Carcinoma |
|
|
| Cecal Disease |
|
|
| Desmoplastic Nodular Medulloblastoma |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Frontotemporal Dementia |
|
|
| Acinar Cell Carcinoma |
|
|
| Esophageal Atresia |
|
|
| Ectopic Cushing Syndrome |
|
|
| Basal Cell Carcinoma |
|
|
| Cranial Nerve Palsy |
|
|
| Prostatic Acinar Adenocarcinoma |
|
|
| Chordoid Glioma |
|
|
| Central Nervous System Benign Neoplasm |
|
|
| Prostate Small Cell Carcinoma |
|
|
| Struma Ovarii |
|
|
| Duodenal Gastrinoma |
|
|
| Meibomian Cyst |
|
|
| Rectum Squamous Cell Carcinoma |
|
|
| Endocrine Organ Benign Neoplasm |
|
|
| Prostate Stromal Sarcoma |
|
|
| Subleukemic Leukemia |
|
|
| Adenosquamous Prostate Carcinoma |
|
|
| Rhabdomyosarcoma |
|
|
| Lung Combined Large Cell Neuroendocrine Carcinoma |
|
|
| Lumbosacral Plexus Lesion |
|
|
| Pleomorphic Xanthoastrocytoma |
|
|
| Cauda Equina Syndrome |
|
|
| Skin Carcinoma |
|
|
| Mucinous Cystadenofibroma |
|
|
| Endometrial Transitional Cell Carcinoma |
|
|
| Pancreas Lymphoma |
|
|
| Bilateral Hypoactive Labyrinth |
|
|
| Tracheal Cancer |
|
|
| Small Cell Osteogenic Sarcoma |
|
|
| Cystitis Cystica |
|
|
| Extracranial Neuroblastoma |
|
|
| Neural Tube Defects |
|
|
| Orbital Cancer |
|
|
| Glycogen-Rich Clear Cell Breast Carcinoma |
|
|
| Cerebellar Medulloblastoma |
|
|
| Papillary Adenoma |
|
|
| Rectum Neuroendocrine Neoplasm |
|
|
| Cerebellopontine Angle Primitive Neuroectodermal Tumor |
|
|
| Gastric Gastrinoma |
|
|
| Large Cell Medulloblastoma |
|
|
| Pancreatic Cystadenoma |
|
|
| Respiratory System Benign Neoplasm |
|
|
| Gallbladder Adenocarcinoma |
|
|
| Vascular Cancer |
|
|
| Anaplastic Ependymoma |
|
|
| Neurohypophysis Granular Cell Tumor |
|
|
| Optic Nerve Astrocytoma |
|
|
| Ovarian Cystic Teratoma |
|
|
| Papilledema |
|
|
| Myoblastoma |
|
|
| Vaginal Tubulovillous Adenoma |
|
|
| Pineal Region Teratoma |
|
|
| Horner'S Syndrome |
|
|
| Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor |
|
|
| Benign Ileal Neoplasm |
|
|
| Thyroid Gland Medullary Carcinoma |
|
|
| Amelanotic Melanoma |
|
|
| Cutaneous Ganglioneuroma |
|
|
| Subungual Glomus Tumor |
|
|
| Myxopapillary Ependymoma |
|
|
| Salpingitis Isthmica Nodosa |
|
|
| Adrenal Gland Disease |
|
|
| Papillary Thymic Adenocarcinoma |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Bile Duct Mucinous Adenocarcinoma |
|
|
| Differentiating Neuroblastoma |
|
|
| Cardiovascular Organ Benign Neoplasm |
|
|
| Neuroblastoma |
|
|
| Pineal Region Choriocarcinoma |
|
|
| Skeletal Muscle Cancer |
|
|
| Obstructive Jaundice |
|
|
| Orbital Disease |
|
|
| Endobronchial Lipoma |
|
|
| Exophthalmos |
|
|
| Vulva Basal Cell Carcinoma |
|
|
| Neurilemmoma |
|
|
| Adrenal Cortex Disease |
|
|
| Muscle Cancer |
|
|
| Pineal Region Meningioma |
|
|
| Hyperinsulinemic Hypoglycemia |
|
|
| Suppression Of Tumorigenicity 12 |
|
|
| Low Grade Glioma |
|
|
| Parathyroid Adenoma |
|
|
| Frontal Lobe Neoplasm |
|
|
| Thymus Sarcomatoid Carcinoma |
|
|
| Multiple Endocrine Neoplasia, Type I |
|
|
| Lipoma Of Spermatic Cord |
|
|
| Paratesticular Lipoma |
|
|
| Bipolar Disorder |
|
|
| Nasal Cavity Olfactory Neuroblastoma |
|
|
| Spinal Cord Disease |
|
|
| Peripheral Nervous System Neoplasm |
|
|
| Von Hippel-Lindau Syndrome |
|
|
| Ovary Leiomyosarcoma |
|
|
| Breast Cancer |
|
|
| Infratentorial Cancer |
|
|
| Mediastinal Lipomatosis |
|
|
| Pancreatic Cancer |
|
|
| Aceruloplasminemia |
|
|
| Anus Basaloid Carcinoma |
|
|
| Gastrointestinal System Benign Neoplasm |
|
|
| Toxic Encephalopathy |
|
|
| Cerebral Degeneration |
|
|
| Vaginal Adenoma |
|
|
| Cell Type Benign Neoplasm |
|
|
| Giant Cell Glioblastoma |
|
|
| Pilomyxoid Astrocytoma |
|
|
| Dementia, Lewy Body |
|
|
| Bone Osteosarcoma |
|
|
| Thyroid Gland Hurthle Cell Carcinoma |
|
|
| Autonomic Nervous System Neoplasm |
|
|
| Schizophrenia |
|
|
| Rhabdomyosarcoma 2 |
|
|
| Thymus Large Cell Carcinoma |
|
|
| Cystic Basal Cell Carcinoma |
|
|
| Pick Disease Of Brain |
|
|
| Vaginal Benign Neoplasm |
|
|
| Prostate Signet Ring Cell Adenocarcinoma |
|
|
| Vulvar Proximal-Type Epithelioid Sarcoma |
|
|
| Central Epithelioid Sarcoma |
|
|
| Ewing Sarcoma |
|
|
| Peripheral Nervous System Disease |
|
|
| Gliosarcoma |
|
|
| Wilms Tumor 1 |
|
|
| Nervous System Disease |
|
|
| Retinitis Pigmentosa |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | SYP | VGNC | VGNC:35534 |
| Rattus norvegicus | SYP | RGD | RGD:3802 |
| Mus musculus | SYP | MGD | MGI:98467 |
| Canis familiaris | SYP | VGNC | VGNC:54605 |
| Macaca mulatta | SYP | VGNC | VGNC:78072 |
| Felis catus | SYP | VGNC | VGNC:65891 |
| Others | SYP | NCBI |