STARD4 - StAR related lipid transfer domain containing 4 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 134429

About STARD4

Cytogenetic location: 5q22.1 Genomic coordinates (GRCh38): 5:111,496,033-111,512,535 (from NCBI)

This gene has 12 transcripts (splice variants), 162 orthologues and 5 paralogues. Ubiquitous expression in duodenum (RPKM 9.8), small intestine (RPKM 9.3) and 22 other tissues.

Summary

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in Cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]

STARD4 Products (7)

mRNA Protein Name
NM_001308056.2 NP_001294985.1 stAR-related lipid transfer protein 4 isoform a
NM_001308057.2 NP_001294986.1 stAR-related lipid transfer protein 4 isoform b
NM_001308058.2 NP_001294987.1 stAR-related lipid transfer protein 4 isoform b
NM_001308059.2 NP_001294988.1 stAR-related lipid transfer protein 4 isoform c
NM_001308060.2 NP_001294989.1 stAR-related lipid transfer protein 4 isoform d
NM_001308061.2 NP_001294990.1 stAR-related lipid transfer protein 4 isoform c
NM_139164.3 NP_631903.1 stAR-related lipid transfer protein 4 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cholesterol binding IDA
IDA: Inferred from direct assay
18403318 GOA
enables cholesterol transfer activity IDA
IDA: Inferred from direct assay
18403318 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in cholesterol import IDA
IDA: Inferred from direct assay
18403318 GOA
involved in cholesterol transport involved in cholesterol storage IDA
IDA: Inferred from direct assay
18403318 GOA
involved in intracellular cholesterol transport IDA
IDA: Inferred from direct assay
18403318 GOA
involved in positive regulation of bile acid biosynthetic process IDA
IDA: Inferred from direct assay
18403318 GOA
involved in positive regulation of cholesterol metabolic process IDA
IDA: Inferred from direct assay
18403318 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21767660 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
21767660 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STARD4 Protein Structure

START

START: START domain (14 - 204)

  • 0
  • 100
  • 205 a.a.
Protein Preferred Names Protein Names

stAR-related lipid transfer protein 4

  • START domain containing 4, sterol regulated

STARD4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STARD4 Q96DR4 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
32296183
Intra
STARD4 Q96DR4 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
32296183
Intra
STARD4 Q96DR4 GDAP1 Homo sapiens Q8TB36
Y2H Prey Pooling
32296183
Intra
STARD4 Q96DR4 GDAP1 Homo sapiens Q8TB36
Y2H Array
32296183
Intra
STARD4 Q96DR4 AGTRAP Homo sapiens Q6RW13-2
Y2H Prey Pooling
32296183
Intra
STARD4 Q96DR4 AGTRAP Homo sapiens Q6RW13-2
Y2H Array
32296183
Intra
STARD4 Q96DR4 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
STARD4 Q96DR4 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra
STARD4 Q96DR4 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra
STARD4 Q96DR4 ARL6IP1 Homo sapiens Q15041
Y2H Array
32296183
Intra
STARD4 Q96DR4 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
32296183
Intra
STARD4 Q96DR4 SYP Homo sapiens P08247
Y2H Array
32296183
Intra
STARD4 Q96DR4 SYP Homo sapiens P08247
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

STARD4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86295 STARD4 Antibody (YA5987) WB, ICC/IF Human

Related Diseases

Diseases Alias
Lipoid Congenital Adrenal Hyperplasia

  • Congenital Adrenal Hyperplasia

  • Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency

  • Congenital Lipoid Adrenal Hyperplasia

  • Lipoid Cah

  • Lipoid Adrenal Hyperplasia

  • Adrenal Hyperplasia 1

  • Cah

  • Clah

  • LCAH

  • Adrenal Hyperplasia I

  • Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism

  • Congenital Adrenal Hyperplasia Lipoid

  • Adrenal Hyperplasia, Congenital

  • Congenital Adrenal Hyperplasia, Lipoid

  • AH1

  • Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism

  • Adrenal Hyperplasia Congenital

  • Hyperplasia, Adrenal, Lipoid, Congenital

  • Congenital Adrenogenital Disorders Associated With Enzyme Deficiency

  • Congenital Adrenal Cortical Hyperplasia

  • Congenital Adrenal Gland Hyperplasia

  • Congenital Adrenogenital Syndrome

  • Congenital Hyperadrenocorticism

  • Congenital Adrenogenitalism

  • Congenital Female Adrenal Pseudohermaphroditism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13880 STARD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21947 Stard4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28464 Stard4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus STARD4 VGNC VGNC:102336
Canis familiaris STARD4 VGNC VGNC:46884
Macaca mulatta STARD4 VGNC VGNC:77947
Rattus norvegicus STARD4 RGD RGD:1309475
Mus musculus STARD4 MGD MGI:2156764
Bos taurus STARD4 VGNC VGNC:35365
Others STARD4 NCBI