MRRF - mitochondrial ribosome recycling factor Gene

Also Known as RRF; MRFF; MTRRF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 92399

About MRRF

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:122,264,882-122,331,337 (from NCBI)

This gene has 12 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 8.8), duodenum (RPKM 7.8) and 25 other tissues.

Summary

This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Oct 2016]

MRRF Products (8)

mRNA	Protein	Name
NM_001173512.3	NP_001166983.1	ribosome-recycling factor, mitochondrial isoform 3 precursor
NM_001346339.2	NP_001333268.1	ribosome-recycling factor, mitochondrial isoform 4
NM_001346341.2	NP_001333270.1	ribosome-recycling factor, mitochondrial isoform 1 precursor
NM_001346343.2	NP_001333272.1	ribosome-recycling factor, mitochondrial isoform 5
NM_001346345.2	NP_001333274.1	ribosome-recycling factor, mitochondrial isoform 6
NM_001346347.2	NP_001333276.1	ribosome-recycling factor, mitochondrial isoform 7
NM_138777.5	NP_620132.1	ribosome-recycling factor, mitochondrial isoform 1 precursor
NM_199177.4	NP_954646.1	ribosome-recycling factor, mitochondrial isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ribosome disassembly	IDA IDA: Inferred from direct assay	19716793	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in mitochondrion	IDA IDA: Inferred from direct assay	18782833	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRRF Protein Structure

RRF

0
100
200
262 a.a.

Protein Preferred Names	Protein Names
ribosome-recycling factor, mitochondrial	ribosome-releasing factor, mitochondrial

MRRF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MRRF	Q96E11	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	MRRF	Q96E11	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	32296183
Intra	MRRF	Q96E11	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	MRRF	Q96E11	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	MRRF	Q96E11	BANP	Homo sapiens	Q8N9N5-2	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	32296183
Intra	MRRF	Q96E11	WIPI2	Homo sapiens	Q9Y4P8-4	Validated Y2H	32296183
Intra	MRRF	Q96E11	WIPI2	Homo sapiens	Q9Y4P8-4	Y2H Array	32296183
Intra	MRRF	Q96E11	WIPI2	Homo sapiens	Q9Y4P8-4	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	ZNF408	Homo sapiens	Q9H9D4	Y2H Array	32296183
Intra	MRRF	Q96E11	ZNF408	Homo sapiens	Q9H9D4	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	ZNF408	Homo sapiens	Q9H9D4	Validated Y2H	32296183
Intra	MRRF	Q96E11	DBT	Homo sapiens	P11182	Anti Tag CoIP	28514442
Intra	MRRF	Q96E11	DBT	Homo sapiens	P11182	Anti Tag CoIP	33961781
Intra	MRRF	Q96E11	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	MRRF	Q96E11	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	SYP	Homo sapiens	P08247	Y2H Prey Pooling	32296183
Intra	MRRF	Q96E11	SYP	Homo sapiens	P08247	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Kearns-Sayre Syndrome	Ophthalmoplegia Mitochondrial Cytopathy KSS Ophthalmoplegia, Pigmentary Degeneration Of Retina, And Cardiomyopathy Oculocraniosomatic Syndrome Chronic Progressive External Ophthalmoplegia With Myopathy Cpeo With Myopathy Total Ophthalmoplegia Ophthalmoplegia-Plus Syndrome Ophthalmoplegia, Progressive External, With Ragged-Red Fibers Cpeo With Ragged-Red Fibers Oculomotor Paralysis Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia Due To Duplication O Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia Due To Duplication Of Mitochondrial Dna Proximal Tubulopathy, Diabetes Mellitus And Cerebellar Ataxia Cpeo With Ragged Red Fibers Ophthalmoplegia Plus Syndrome Ophthalmoplegia, Progressive External, With Ragged Red Fibers Kearns-Sayre Mitochondrial Cytopathy Mitochondrial Myopathies
Uremic Neuropathy
Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis	SANDO Mitochondrial Recessive Ataxia Syndrome Spinocerebellar Ataxia With Epilepsy Epilepsy, Progressive Myoclonic 5 Epm5 Miras SCAE Sensory Ataxic Neuropathy With Mitochondrial Dna Deletions, Autosomal Recessive Autosomal Recessive Sensory Ataxic Neuropathy With Mitochondrial Dna Deletions Progressive Myoclonic Epilepsy Type 5 Pme Type 5 Progressive Myoclonus Epilepsy Type 5 Sensory Ataxic Neuropathy-Dysarthria-Ophthalmoparesis Syndrome Recessive Mitochondrial Ataxia Syndrome Sensory Ataxic Neuropathy Dysarthria And Ophthalmoparesis Mitochondrial Spinocerebellar Ataxia-Epilepsy Syndrome Mscae Sensory Ataxic Neuropathy With Mitochondrial Dna Deletions Autosomal Recessive Progressive Myoclonic Epilepsy With Sensory Ataxic Neuropathy Epilepsy, Progressive Myoclonic, 5 Ataxia Neuropathy Spectrum
Chronic Progressive External Ophthalmoplegia	Progressive External Ophthalmoplegia Cpeo Peo Ophthalmoplegia, Chronic Progressive External Ophthalmoplegia, External, Progressive, Chronic Graefe Disease Peo - [Progressive External Ophthalmoplegia] Ophthalmoplegia Plus Syndrome
Myoclonic Epilepsy Associated With Ragged-Red Fibers	Merrf Syndrome MERRF Fukuhara Syndrome Myoclonic Epilepsy Associated With Ragged Red Fibers Myoencephalopathy Ragged-Red Fiber Disease Myoclonic Epilepsy - Ragged Red Fibers Myoclonus Epilepsy And Ragged Red Fibers Myoclonus With Epilepsy And With Ragged Red Fibers Myoclonic Epilepsy With Ragged Red Fibers Myoclonic Epilepsy With Ragged-Red Fibers Fukuhara Disease Myoclonus Epilepsy Associated With Ragged-Red Fibres Myoclonus With Epilepsy With Ragged Red Fibers
Mitochondrial Myopathy	Mitochondrial Myopathies Mitochondrial Cytopathy Myopathies In Mitochondrial Disorders
Mitochondrial Encephalomyopathy	Mitochondrial Encephalomyopathies Encephalomyopathy, Mitochondrial
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes	Melas Syndrome MELAS Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
Leigh Syndrome	Leigh Disease Infantile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency LS Sne Leigh'S Disease Leigh Syndrome Due To Mitochondrial Complex I Deficiency Necrotizing Encephalopathy, Infantile Subacute, Of Leigh Subacute Necrotizing Encephalomyelopathy Necrotizing Encephalopathy Infantile Subacute Of Leigh Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency Infantile Necrotizing Encephalomyelopathy Juvenile Subacute Necrotizing Encephalomyelopathy Leigh'S Necrotizing Encephalopathy Subacute Necrotizing Encephalopathy Juvenile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency Leigh Syndrome Due To Mitochondrial Complex V Deficiency Encephalopathy, Subacute Necrotizing, Infantile Encephalopathy, Subacute Necrotizing, Juvenile Maternally Inherited Leigh Syndrome Subacute Necrotising Encephalomyelopathy Subacute Necrotising Encephalopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08691	MRRF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MRRF	MGD	MGI:1915121
Rattus norvegicus	MRRF	RGD	RGD:1305897
Canis familiaris	MRRF	VGNC	VGNC:43428
Macaca mulatta	MRRF	VGNC	VGNC:74927
Bos taurus	MRRF	VGNC	VGNC:102827
Others	MRRF	NCBI