KRT40 - keratin 40 Gene

Homo sapiens

Also known as K40; KA36; CK-40

Gene ID: 125115 | Gene type: protein coding

About KRT40

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,977,715-40,987,135 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 89 orthologues and 68 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the Cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

KRT40 Products(3)

mRNA	Protein	Name
NM_001385217.1	NP_001372146.1	keratin, type I cytoskeletal 40
NM_001389244.1	NP_001376173.1	keratin, type I cytoskeletal 40
NM_182497.4	NP_872303.2	keratin, type I cytoskeletal 40

KRT40 Protein Structure

Filament

0
100
200
300
400
431 a.a.

Protein Preferred Names

Protein Names

keratin, type I cytoskeletal 40

cytokeratin-40

Related Diseases

Diseases

Alias

Heart Fibrosarcoma

Cardiac Fibrosarcoma

Fibrosarcoma Of The Heart

White Sponge Nevus 1

White Sponge Nevus Of Cannon	Leukokeratosis, Hereditary Mucosal
Hereditary Mucosal Leukokeratosis	White Sponge Nevus
WSN1	Wsn
Cannon'S Disease	Familial White Folded Mucosal Dysplasia
Hereditary Leukokeratosis	Hereditary Oral Keratosis
Leukokeratosis Of Oral Mucosa	Nevus Of Cannon
White Folded Gingivostomatosis	White Gingivostomatitis
White Sponge Naevus	White Sponge Nevus Of Mucosa

Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma	Bullous Ichthyosiform Erythroderma
EHK	Bullous Erythroderma Ichthyosiformis Congenita Of Brocq
Bcie	Bie
Epidermolytic Ichthyosis	Ichthyosis Bullosa Of Siemens
Superficial Epidermolytic Ichthyosis	Hyperkeratosis, Epidermolytic
Congenital Bullous Ichthyosiform Erythroderma	Bullous Type Ichthyosis
Epidermolytic Palmoplantar Hyperkeratosis	Bullous Ichthyosiform Erythroderma Congenita
Bullous Erythroderma Ichthyosiforme	Sei
Epidermolytic Hyperkeratosis Late-Onset	Epidermolytic Hyperkeratosis, Late-Onset

Pachyonychia Congenita 1

Pachyonychia Congenita	Jadassohn-Lewandowsky Syndrome
Pachyonychia Congenita Syndrome	PC1
Pachyonychia Congenita, Jadassohn-Lewandowsky Type	Congenital Pachyonychia
Pachyonychia Congenita, Type 1	Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly
Jadassohn-Lewandowsky Syndrome, Formerly	Jackson-Lawler Type Pachyonychia Congenita
Pachyonychia Congenita Type 1	Jackson-Lawler Syndrome
Jadassohn-Lewandowski Syndrome	Pc
Pachyonychia Congenita Jackson-Lawler Type	Pachyonychia Congenita Jadassohn-Lewandowsky Type
Pachyonychia Congenita Jackson Lawler Type	Pc-1
Pachyonychia Congenita, Jadassohn Lewandowsky Type	Pachyonychia Congenita, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07456	KRT40 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KRT40	VGNC	VGNC:74134
Bos taurus	KRT40	VGNC	VGNC:30733
Mus musculus	KRT40	MGD	MGI:3629968
Canis familiaris	KRT40	VGNC	VGNC:42529
Rattus norvegicus	KRT40	RGD	RGD:1359145

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