SCOC - short coiled-coil protein Gene

Also Known as SCOCO; UNC-69; HRIHFB2072

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 60592

About SCOC

This gene has 9 transcripts (splice variants) and 271 orthologues. Ubiquitous expression in brain (RPKM 55.6), thyroid (RPKM 34.6) and 25 other tissues.

Summary

This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on chromosomes 1 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

SCOC Products (8)

mRNA Protein Name
NM_001153446.1 NP_001146918.1 short coiled-coil protein isoform 4
NM_001153484.2 NP_001146956.2 short coiled-coil protein isoform 1
NM_001153552.2 NP_001147024.2 short coiled-coil protein isoform 3
NM_001153585.1 NP_001147057.1 short coiled-coil protein isoform 4
NM_001153635.1 NP_001147107.1 short coiled-coil protein isoform 5
NM_001153663.1 NP_001147135.1 short coiled-coil protein isoform 2
NM_001153690.1 NP_001147162.1 short coiled-coil protein isoform 6
NM_032547.3 NP_115936.2 short coiled-coil protein isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20195357 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of macroautophagy IDA
IDA: Inferred from direct assay
22354037 GOA
involved in regulation of protein complex stability IMP
IMP: Inferred from mutant phenotype
22354037 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with endosome IDA
IDA: Inferred from direct assay
22354037 GOA
colocalizes with trans-Golgi network IDA
IDA: Inferred from direct assay
22354037 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCOC Protein Structure

DUF2205

DUF2205: Predicted coiled-coil protein (DUF2205) (79 - 159)

  • 0
  • 100
  • 159 a.a.
Protein Preferred Names Protein Names

short coiled-coil protein

SCOC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCOC Q9UIL1 SCHIP1 Homo sapiens P0DPB3
TAP
20195357
Intra
SCOC Q9UIL1 FEZ1 Homo sapiens Q99689
IF
22354037
Intra
SCOC Q9UIL1 TCF4 Homo sapiens P15884
Validated Y2H
25416956
Intra
SCOC Q9UIL1 TCF4 Homo sapiens P15884
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Carotid Artery Dissection

  • Dissection Of Carotid Artery
Cannabis Dependence

  • Marijuana Abuse

  • Cannabinoid Addiction

  • Cannabinoid Dependence

  • Cannabis Addiction
Hallucinogen Dependence

  • Hallucinogen Addiction
Pyromania

  • Firesetting Behavior

  • Pathological Firesetting

  • Pathological Fire-Setting
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175340 Kv7.2/Kv7.3 activator-3 Activator / Unkown
HY-RS12558 SCOC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SCOC RGD RGD:1311860
Bos taurus SCOC VGNC VGNC:34360
Mus musculus SCOC MGD MGI:1927654
Others SCOC NCBI