FEZ1 - fasciculation and elongation protein zeta 1 Gene

Also Known as UNC-76

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9638

About FEZ1

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,442,881-125,496,265 (from NCBI)

This gene has 17 transcripts (splice variants), 219 orthologues and 1 paralogue. Biased expression in brain (RPKM 74.3), urinary bladder (RPKM 9.7) and 4 other tissues.

Summary

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

FEZ1 Products (2)

mRNA Protein Name
NM_005103.5 NP_005094.1 fasciculation and elongation protein zeta-1 isoform 1
NM_022549.4 NP_072043.1 fasciculation and elongation protein zeta-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14690447 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
25495476 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
25495476 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FEZ1 Protein Structure

FEZ

FEZ: FEZ-like protein (58 - 299)

  • 0
  • 100
  • 200
  • 300
  • 392 a.a.
Protein Preferred Names Protein Names

fasciculation and elongation protein zeta-1

  • zygin I

FEZ1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FEZ1 Q99689 SCOC Homo sapiens Q9UIL1
Anti Tag CoIP
33961781
Intra
FEZ1 Q99689 NEK1 Homo sapiens Q96PY6
Pull Down
14690447
Intra
FEZ1 Q99689 NEK1 Homo sapiens Q96PY6
Y2H
14690447
Intra
FEZ1 Q99689 HTT Homo sapiens P42858
Y2H
17500595
Intra
FEZ1 Q99689 HTT Homo sapiens P42858
Anti Tag CoIP
28514442
Intra
FEZ1 Q99689 HTT Homo sapiens P42858
Pull Down
15383276
Intra
FEZ1 Q99689 CEP126 Homo sapiens Q9P2H0
Y2H
15383276
Intra
FEZ1 Q99689 TXNDC9 Homo sapiens O14530
Anti Tag CoIP
16169070
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lissencephaly 1

  • LIS1

  • Classic Lissencephaly

  • Ils

  • Subcortical Laminar Heterotopia

  • Lissencephaly Due To Lis1 Mutation

  • Lissencephaly Sequence, Isolated

  • Lissencephaly, Classic

  • Pafah1b1-Related Lissencephaly

  • Classical Lissencephaly

  • Lissencephaly Type 1

  • Lissencephaly-1

  • Subcortical Band Heterotopia

  • Double Cortex

  • Lissencephaly Classic

  • Lissencephaly Sequence Isolated

  • Isolated Lissencephaly Sequence

  • Type 1 Lissencephaly

  • Lissencephaly Syndrome Type 1

  • SBH

  • Sclh

  • Lissencephaly, Type 1

  • Type I Lissencephaly
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Jacobsen Syndrome

  • Chromosome 11q Deletion Syndrome

  • Partial 11q Monosomy Syndrome

  • Jacobsen Distal 11q Deletion Syndrome

  • JBS

  • 11q Partial Monosomy Syndrome

  • Chromosome 11q Deletion

  • 11q Deletion

  • 11q Monosomy

  • Deletion 11q

  • Monosomy 11q

  • Partial Monosomy 11q

  • 11q Deletion Disorder

  • 11q Deletion Syndrome

  • 11q Terminal Deletion Disorder

  • 11q- Deletion Syndrome

  • 11q23 Deletion Disorder

  • Jacobsen Thrombocytopenia

  • 11q Terminal Deletion Syndrome

  • Del(11)(Q23.3)

  • Del(11)(Qter)

  • Distal Deletion 11q

  • Distal Monosomy 11q

  • Monosomy 11qter

  • Telomeric Deletion 11q

  • Paris-Trousseau Thrombocytopenia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04870 FEZ1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07934 LZTS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22620 Lzts1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FEZ1 VGNC VGNC:72639
Mus musculus FEZ1 MGD MGI:2670976
Rattus norvegicus FEZ1 RGD RGD:619708
Felis catus FEZ1 VGNC VGNC:62234
Canis familiaris FEZ1 VGNC VGNC:40827
Bos taurus FEZ1 VGNC VGNC:28957
Others FEZ1 NCBI