SSX2 - SSX family member 2 Gene

Also Known as SSX; HD21; CT5.2; CT5.2A; HOM-MEL-40

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6757

About SSX2

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:52,696,896-52,707,227 (from NCBI)

This gene has 3 transcripts (splice variants), 101 orthologues, 7 paralogues and is associated with 28 phenotypes. Restricted expression toward testis (RPKM 18.4).

Summary

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in Cancer patients, and are potentially useful targets in Cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]

SSX2 Products (3)

mRNA	Protein	Name
NM_001278697.2	NP_001265626.1	protein SSX2 isoform c
NM_003147.6	NP_003138.3	protein SSX2 isoform a
NM_175698.4	NP_783629.1	protein SSX2 isoform b

SSX2 Protein Structure

KRAB

SSXRD

0
100
188 a.a.

Protein Preferred Names	Protein Names
protein SSX2	cancer/testis antigen 5.2

SSX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SSX2	Q16385	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	SSX2	Q16385	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	SSX2	Q16385	ZMIZ2	Homo sapiens	Q8NF64-2	Y2H Array	25416956
Intra	SSX2	Q16385	SSX2IP	Homo sapiens	Q9Y2D8	Pull Down	12007189
Intra	SSX2	Q16385	SSX2IP	Homo sapiens	Q9Y2D8	IF	12007189
Intra	SSX2	Q16385	SSX2IP	Homo sapiens	Q9Y2D8	Y2H	12007189
Intra	SSX2	Q16385	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	SSX2	Q16385	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	SSX2	Q16385	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	SSX2	Q16385	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	25416956
Intra	SSX2	Q16385	SYCE1	Homo sapiens	Q8N0S2	Y2H Prey Pooling	25416956
Intra	SSX2	Q16385	ZBED1	Homo sapiens	O96006	Y2H Prey Pooling	25416956
Intra	SSX2	Q16385	ZBED1	Homo sapiens	O96006	Y2H Array	25416956
Intra	SSX2	Q16385	RAB3IP	Homo sapiens	Q96QF0	Validated Y2H	25416956
Intra	SSX2	Q16385	RAB3IP	Homo sapiens	Q96QF0	Y2H Array	25416956
Intra	SSX2	Q16385	RAB3IP	Homo sapiens	Q96QF0	Y2H Prey Pooling	25416956
Intra	SSX2	Q16385	RAB3IP	Homo sapiens	Q96QF0-2	IF	12007189
Intra	SSX2	Q16385	AKAP9	Homo sapiens	Q99996-2	Validated Y2H	25416956
Intra	SSX2	Q16385	AKAP9	Homo sapiens	Q99996-2	Anti Tag CoIP	28514442
Intra	SSX2	Q16385	AKAP9	Homo sapiens	Q99996-2	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Monophasic Synovial Sarcoma	Monophasic Sarcoma Of Synovium
Synovium Cancer	Malignant Tumor Of Synovium Synovial Neoplasm
Lung Sarcoma	Pulmonary Sarcoma
Biphasic Synovial Sarcoma	Synovial Sarcoma, Biphasic Biphasic Sarcoma Of Synovium
Seminoma	Seminoma, Pure
Malignant Glandular Tumor Of Peripheral Nerve Sheath	Glandular Mpnst Glandular Malignant Peripheral Nerve Sheath Tumor
Spindle Cell Synovial Sarcoma	Synovial Sarcoma With Spindle Cell Components Synovial Sarcoma, Monophasic Fibrous Synovial Sarcoma, Spindle Cell
Epithelioid Cell Synovial Sarcoma	Synovial Sarcoma, Epithelioid Cell Epithelioid Synovial Sarcoma
Sarcomatoid Renal Cell Carcinoma	Renal Cell Carcinoma, Spindle Cell
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis
Liver Fibroma	Fibroma Of The Liver Liver Solitary Fibrous Tumor
Kidney Hemangiopericytoma	Hemangiopericytoma Of Kidney Renal Hemangiopericytoma
Cellular Neurofibroma
Spindle Cell Thymoma	Medullary Thymoma Thymoma, Medullary Thymoma, Type A
Kidney Sarcoma	Renal Sarcoma Sarcoma Of Kidney
Extraskeletal Mesenchymal Chondrosarcoma	Mesenchymal Extraosseous Chondrosarcoma
Heart Sarcoma	Cardiac Sarcoma Sarcoma Of Heart
Spindle Cell Sarcoma	Sarcoma Sarcoma Spindle Cell Sarcoma, Spindle Cell Sarcoma - Category
Epithelioid Malignant Peripheral Nerve Sheath Tumor	Epithelioid Mpnst Malignant Epithelioid Neoplasm Of The Peripheral Nerve Sheath
Malignant Mesenchymoma	Malignant Mesenchymal Tumor Mesenchymoma, Malignant Sarcoma Rat Malignant Renal Mesenchymal Tumor
Myxofibrosarcoma	Fibromyxosarcoma Fibromyxoid Sarcoma Myxoid Malignant Fibrous Histiocytoma Dermatofibrosarcoma Protuberans, Myxoid
Sarcomatoid Mesothelioma	Malignant Fibrous Mesothelioma Spindled Mesothelioma
Spermatic Cord Cancer	Malignant Tumor Of Spermatic Cord Malignant Tumor Of The Spermatic Cord Spermatic Cord Ca Malignant Neoplasm Of Spermatic Cord
Extraosseous Chondrosarcoma	Extraskeletal Myxoid Chondrosarcoma
Well-Differentiated Liposarcoma	Atypical Lipomatous Tumor Atypical Lipoma Alt Wdls Liposarcoma, Well Differentiated Pleomorphic Lipoma
Desmoplastic Small Round Cell Tumor	Dsrct Desmoplastic Small Round-Cell Tumor Desmoplastic Small Round-Cell Neoplasm
Hemangiopericytoma, Malignant	Hemangiopericytoma Haemangiopericytic Meningioma Malignant Hemangiopericytoma Solitary Fibrous Tumor
Chondrosarcoma, Extraskeletal Myxoid	Extraskeletal Myxoid Chondrosarcoma Emc Myxoid Extraosseous Chondrosarcoma
Meninges Sarcoma	Meningeal Sarcoma Sarcoma Of Meninges Meningothelial Sarcoma Leptomeningeal Sarcoma
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Spermatocytoma	Spermatocytic Seminoma
Pleomorphic Liposarcoma	Pls Liposarcoma Pleomorphic Liposarcoma, Pleomorphic
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Ovarian Angiosarcoma	Hemangiosarcoma Of Ovary
Clear Cell Sarcoma	Sarcoma, Clear Cell Adult Soft Part Clear Cell Sarcoma Clear Cell Sarcoma Of Soft Parts Malignant Melanoma Of Soft Parts Malignant Melanoma Of Soft Tissues Melanoma, Malignant, Of Soft Parts Sarcoma Clear Cell
Myxoid Chondrosarcoma
Synovium Neoplasm	Synovial Neoplasm Tumor Of Synovium
Cellular Myxoid Liposarcoma	Round Cell Liposarcoma
Perivascular Tumor	Malignant Perivascular Cancer
Skeletal Muscle Cancer	Malignant Tumor Of Skeletal Muscle Skeletal Muscle Neoplasm
Alveolar Soft Part Sarcoma	ASPS Alveolar Soft-Part Sarcoma Sarcoma, Alveolar Soft Part Alveolar Soft Tissue Sarcoma Sarcoma Alveolar Soft Part Adult Alveolar Soft-Part Sarcoma Childhood Alveolar Soft-Part Sarcoma
Epithelioid Sarcoma	Epithelioid Cell Sarcoma Sarcoma Epithelioid Sarcoma, Epithelioid
Mesenchymal Cell Neoplasm	Benign Miscellaneous Mesenchymal Tumor Mesenchymal Tumor Mesenchymal Tumors
Rhabdomyosarcoma
Pyriform Sinus Cancer	Malignant Neoplasm Of Pyriform Fossa Malignant Neoplasm Of The Pyriform Fossa Malignant Tumor Of Pyriform Fossa
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Kidney Cortex Disease
Rhabdoid Cancer	Rhabdoid Tumor Malignant Rhabdoid Tumor Malignant Rhabdoid Tumour Rhabdoid Sarcoma Rhabdoid Tumor Predisposition Syndrome 1 Rhabdoid Tumor Predisposition Syndrome 2 Atypical Teratoid Rhabdoid Tumor Brain Tumor, Posterior Fossa, Of Infancy, Familial Atypical Teratoid/Rhabdoid Tumor
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Congenital Mesoblastic Nephroma	Mesoblastic Nephroma Nephroma, Mesoblastic
Thymus Sarcomatoid Carcinoma	Thymic Carcinosarcoma Thymic Sarcomatoid Carcinoma
Kidney Fibrosarcoma	Fibrosarcoma Of The Kidney
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Embryonal Rhabdomyosarcoma	Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma Embryonal Botryoid Rhabdomyosarcoma Erms Spindle Cell Rhabdomyosarcomas
Neurilemmomatosis	Schwannomatosis Neurofibromatosis Type 3 Nf3 Neurilemmomatosis Congenital Cutaneous Neurinomatosis Congenital Cutaneous Neurilemmomatosis Multiple Neurilemmomas Multiple Schwannomas Neurilemmomatosis, Congenital Cutaneous Schwannomatosis 1 Neurofibromatosis 3 Mixed Central And Peripheral Neurofibromatosis Nf3 - [Neurofibromatosis Type 3]
Endometrial Stromal Sarcoma	Ess Endometrial Stromal Sarcoma, High Grade Undifferentiated Endometrial Sarcoma Stromal Sarcoma Of The Corpus Uteri Sarcoma Endometrial Stromal Sarcoma, Endometrial Stromal Undifferentiated Stromal Sarcoma
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13837	SSX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13838	SSX2IP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown