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TAX1BP1 - Tax1 binding protein 1 Gene

Also Known as T6BP; TXBP151; CALCOCO3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8887

About TAX1BP1

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,739,373-27,829,767 (from NCBI)

This gene has 13 transcripts (splice variants), 290 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 48.4), thyroid (RPKM 48.2) and 25 other tissues.

Summary

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced Apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with Apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

TAX1BP1 Products (6)

mRNA	Protein	Name
NM_001079864.3	NP_001073333.1	tax1-binding protein 1 isoform 2
NM_001206901.1	NP_001193830.1	tax1-binding protein 1 isoform 2
NM_001206902.2	NP_001193831.1	tax1-binding protein 1 isoform 3
NM_001362794.2	NP_001349723.1	tax1-binding protein 1 isoform 4
NM_001362795.2	NP_001349724.1	tax1-binding protein 1 isoform 5
NM_006024.7	NP_006015.4	tax1-binding protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10920205	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	27736772	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	27736772	GOA
involved in negative regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	28898289	GOA
involved in protein localization to phagocytic vesicle	IDA IDA: Inferred from direct assay	28898289	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in mitochondrion	IDA IDA: Inferred from direct assay	27736772	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAX1BP1 Protein Structure

CALCOCO1

0
200
400
600
789 a.a.

Protein Preferred Names	Protein Names
tax1-binding protein 1	TRAF6-binding protein

TAX1BP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TAX1BP1	Q86VP1	PLEKHN1	Homo sapiens	Q494U1	Y2H Array	31515488
Intra	TAX1BP1	Q86VP1	PLEKHN1	Homo sapiens	Q494U1	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	NMRK1	Homo sapiens	Q9NWW6	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	NMRK1	Homo sapiens	Q9NWW6	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	NMRK1	Homo sapiens	Q9NWW6	Y2H Array	25416956
Intra	TAX1BP1	Q86VP1	TBC1D15	Homo sapiens	Q8TC07	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	EMILIN1	Homo sapiens	Q9Y6C2-2	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	TCAF1	Homo sapiens	Q9Y4C2-2	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	FAM168A	Homo sapiens	Q92567-2	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	TRIM45	Homo sapiens	Q9H8W5-2	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	CXXC1	Homo sapiens	Q9P0U4-2	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	SSX2	Homo sapiens	Q16385	Y2H Array	25416956
Intra	TAX1BP1	Q86VP1	SSX2	Homo sapiens	Q16385	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	RAD18	Homo sapiens	Q9NS91	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	RAD18	Homo sapiens	Q9NS91	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	TNIP3	Homo sapiens	Q96KP6	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	TNIP3	Homo sapiens	Q96KP6	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	TNIP3	Homo sapiens	Q96KP6	Y2H Array	31515488
Intra	TAX1BP1	Q86VP1	MRPL53	Homo sapiens	Q96EL3	Validated Y2H	25416956
Intra	TAX1BP1	Q86VP1	MRPL53	Homo sapiens	Q96EL3	Y2H Array	25416956
Intra	TAX1BP1	Q86VP1	MRPL53	Homo sapiens	Q96EL3	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	TSEN2	Homo sapiens	Q8NCE0	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	MAP1LC3C	Homo sapiens	Q9BXW4	Y2H Array	32296183
Intra	TAX1BP1	Q86VP1	MAP1LC3C	Homo sapiens	Q9BXW4	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	UBC	Homo sapiens	P0CG48	Pull Down	18239685
Intra	TAX1BP1	Q86VP1	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	TNIP1	Homo sapiens	Q15025	Validated Y2H	25416956
Intra	TAX1BP1	Q86VP1	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	18239685
Intra	TAX1BP1	Q86VP1	TRAF6	Homo sapiens	Q9Y4K3	Y2H	21988832
Intra	TAX1BP1	Q86VP1	TRAF6	Homo sapiens	Q9Y4K3	Y2H	10920205
Intra	TAX1BP1	Q86VP1	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	10920205
Intra	TAX1BP1	Q86VP1	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	COG7	Homo sapiens	P83436	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	COG7	Homo sapiens	P83436	Y2H Array	31515488
Intra	TAX1BP1	Q86VP1	COG7	Homo sapiens	P83436	Y2H Array	25416956
Intra	TAX1BP1	Q86VP1	FOXC2	Homo sapiens	Q99958	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	FOXC2	Homo sapiens	Q99958	Validated Y2H	25416956
Intra	TAX1BP1	Q86VP1	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	CWF19L2	Homo sapiens	Q2TBE0	Y2H Array	25416956
Intra	TAX1BP1	Q86VP1	CWF19L2	Homo sapiens	Q2TBE0	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	MRPL11	Homo sapiens	Q9Y3B7	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	MRPL11	Homo sapiens	Q9Y3B7	Validated Y2H	25416956
Intra	TAX1BP1	Q86VP1	MRPL11	Homo sapiens	Q9Y3B7	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	MRPL11	Homo sapiens	Q9Y3B7	Y2H Array	25416956
Intra	TAX1BP1	Q86VP1	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	TCEA2	Homo sapiens	Q15560	Y2H Array	25416956
Intra	TAX1BP1	Q86VP1	TCEA2	Homo sapiens	Q15560	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	CBX8	Homo sapiens	Q9HC52	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	LITAF	Homo sapiens	Q99732	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	L3MBTL2	Homo sapiens	Q969R5	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	LGALS8	Homo sapiens	O00214	Validated Y2H	25416956
Intra	TAX1BP1	Q86VP1	LGALS8	Homo sapiens	O00214	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	LGALS8	Homo sapiens	O00214	Y2H Array	29892012
Intra	TAX1BP1	Q86VP1	ZNF446	Homo sapiens	Q9NWS9-2	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	ARK2N	Homo sapiens	Q96B23	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	LMO3	Homo sapiens	Q8TAP4	Validated Y2H	25416956
Intra	TAX1BP1	Q86VP1	EMILIN1	Homo sapiens	Q9Y6C2	Validated Y2H	25416956
Intra	TAX1BP1	Q86VP1	EMILIN1	Homo sapiens	Q9Y6C2	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	DSTN	Homo sapiens	P60981	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	GABARAPL1	Homo sapiens	Q9H0R8	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	q8wu02_human	Homo sapiens	Q8WU02	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	TAX1BP1	Q86VP1	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	TAX1BP1	Q86VP1	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	TAX1BP1	Q86VP1	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	RALBP1	Homo sapiens	Q15311	Anti Tag CoIP	18239685
Intra	TAX1BP1	Q86VP1	RALBP1	Homo sapiens	Q15311	Anti Tag CoIP	17703191
Intra	TAX1BP1	Q86VP1	FAM168A	Homo sapiens	Q92567	Y2H Array	25416956
Intra	TAX1BP1	Q86VP1	FAM168A	Homo sapiens	Q92567	Y2H Prey Pooling	25416956
Intra	TAX1BP1	Q86VP1	CHUK	Homo sapiens	O15111	Anti Bait CoIP	21765415
Intra	TAX1BP1	Q86VP1	CHUK	Homo sapiens	O15111	Protein Kinase Assay	21765415
Intra	TAX1BP1	Q86VP1	TSHZ3	Homo sapiens	Q63HK5	Validated Y2H	25416956
Intra	TAX1BP1	Q86VP1	TSHZ3	Homo sapiens	Q63HK5	Y2H Array	25416956
Intra	TAX1BP1	Q86VP1	LRATD2	Homo sapiens	Q96KN1	Validated Y2H	32296183
Intra	TAX1BP1	Q86VP1	CXXC1	Homo sapiens	Q9P0U4	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

TAX1BP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82503	TAX1BP1 Antibody (YA2248)	WB, IHC-P	Human
HY-P82503A	TAX1BP1 Antibody (YA2248)(PBS only)	WB, IHC-P	Human

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14227	TAX1BP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22048	Tax1bp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28566	Tax1bp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TAX1BP1	VGNC	VGNC:47125
Felis catus	TAX1BP1	VGNC	VGNC:102711
Mus musculus	TAX1BP1	MGD	MGI:1289308
Macaca mulatta	TAX1BP1	VGNC	VGNC:78101
Bos taurus	TAX1BP1	VGNC	VGNC:35619
Rattus norvegicus	TAX1BP1	RGD	RGD:708579
Others	TAX1BP1	NCBI