L3MBTL2 - L3MBTL histone methyl-lysine binding protein 2 Gene

Homo sapiens

Also known as L3MBT; H-l(3)mbt-l

Gene ID: 83746 | Gene type: protein coding

About L3MBTL2

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,205,312-41,231,271 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues and 18 paralogues. Ubiquitous expression in lymph node (RPKM 7.9), testis (RPKM 7.9) and 25 other tissues.

Summary

Enables methylated histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including ectoderm development; regulation of histone modification; and stem cell proliferation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

L3MBTL2 Products(1)

mRNA	Protein	Name
NM_031488.5	NP_113676.2	lethal(3)malignant brain tumor-like protein 2

L3MBTL2 Protein Structure

MBT

0
200
400
600
705 a.a.

Protein Preferred Names

Protein Names

lethal(3)malignant brain tumor-like protein 2

H-l(3)mbt-like protein 2

Related Diseases

Diseases

Alias

Idh-Mutant Anaplastic Astrocytoma

Idh-Wildtype Anaplastic Astrocytoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07485	L3MBTL2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	L3MBTL2	VGNC	VGNC:42558
Felis catus	L3MBTL2	VGNC	VGNC:63182
Macaca mulatta	L3MBTL2	VGNC	VGNC:74074
Bos taurus	L3MBTL2	VGNC	VGNC:30763
Mus musculus	L3MBTL2	MGD	MGI:2443584
Rattus norvegicus	L3MBTL2	RGD	RGD:1308569

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