L3MBTL2 - L3MBTL histone methyl-lysine binding protein 2 Gene
Also Known as L3MBT; H-l(3)mbt-l
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 83746
About L3MBTL2
Cytogenetic location: 22q13.2
Genomic coordinates (GRCh38): 22:41,205,312-41,231,271 (from NCBI)
This gene has 9 transcripts (splice variants), 212 orthologues and 18 paralogues. Ubiquitous expression in lymph node (RPKM 7.9), testis (RPKM 7.9) and 25 other tissues.
Summary
Enables methylated histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including ectoderm development; regulation of histone modification; and stem cell proliferation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
L3MBTL2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_031488.5 | NP_113676.2 | lethal(3)malignant brain tumor-like protein 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables histone binding |
IPI
IPI: Inferred from physical interaction
|
17540172 | GOA |
| enables methylated histone binding |
IDA
IDA: Inferred from direct assay
|
19233876 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
L3MBTL2 Protein Structure
MBT
MBT: mbt repeat (214 - 287)
MBT
MBT: mbt repeat (327 - 389)
MBT
MBT: mbt repeat (432 - 508)
MBT
MBT: mbt repeat (540 - 604)
- 0
- 200
- 400
- 600
- 705 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
lethal(3)malignant brain tumor-like protein 2 |
|
L3MBTL2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
L3MBTL2 | Q969R5 | TEKT1 | Homo sapiens | Q969V4 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | TEKT1 | Homo sapiens | Q969V4 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | TEKT1 | Homo sapiens | Q969V4 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | BEND7 | Homo sapiens | Q8N7W2-2 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | BEND7 | Homo sapiens | Q8N7W2-2 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | BEND7 | Homo sapiens | Q8N7W2-2 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | BEND7 | Homo sapiens | Q8N7W2-2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | BEND7 | Homo sapiens | Q8N7W2-2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | TBC1D9B | Homo sapiens | Q66K14-2 | 25416956 | |
|
Intra
|
L3MBTL2 | Q969R5 | TBC1D9B | Homo sapiens | Q66K14-2 | 25416956 | |
|
Intra
|
L3MBTL2 | Q969R5 | TBC1D9B | Homo sapiens | Q66K14-2 | 25416956 | |
|
Intra
|
L3MBTL2 | Q969R5 | PHF10 | Homo sapiens | Q8WUB8-2 | 25416956 | |
|
Intra
|
L3MBTL2 | Q969R5 | PHF10 | Homo sapiens | Q8WUB8-2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | PHF10 | Homo sapiens | Q8WUB8-2 | 25416956 | |
|
Intra
|
L3MBTL2 | Q969R5 | PHF10 | Homo sapiens | Q8WUB8-2 | 25416956 | |
|
Intra
|
L3MBTL2 | Q969R5 | GAS8 | Homo sapiens | O95995 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | GAS8 | Homo sapiens | O95995 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | GPRASP3 | Homo sapiens | Q6PI77 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | GPRASP3 | Homo sapiens | Q6PI77 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | CARD9 | Homo sapiens | Q9H257-2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | CARD9 | Homo sapiens | Q9H257-2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | CARD9 | Homo sapiens | Q9H257-2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | NRF1 | Homo sapiens | Q16656-4 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | NRF1 | Homo sapiens | Q16656-4 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZNF467 | Homo sapiens | Q7Z7K2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZNF467 | Homo sapiens | Q7Z7K2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | POU6F2 | Homo sapiens | P78424 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | POU6F2 | Homo sapiens | P78424 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | RBAK | Homo sapiens | Q9NYW8 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | RBAK | Homo sapiens | Q9NYW8 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | RBAK | Homo sapiens | Q9NYW8 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | TBC1D9B | Homo sapiens | A1L3A9 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | TBC1D9B | Homo sapiens | A1L3A9 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | BIVM | Homo sapiens | Q86UB2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | BIVM | Homo sapiens | Q86UB2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | SSUH2 | Homo sapiens | Q9Y2M2-2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | SSUH2 | Homo sapiens | Q9Y2M2-2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | SSUH2 | Homo sapiens | Q9Y2M2-2 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZFY | Homo sapiens | P08048 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZFY | Homo sapiens | P08048 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZFY | Homo sapiens | P08048 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZFY | Homo sapiens | P08048 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZFY | Homo sapiens | P08048 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZNF829 | Homo sapiens | Q3KNS6-3 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZNF829 | Homo sapiens | Q3KNS6-3 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | FAM217B | Homo sapiens | Q9NTX9 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | FAM217B | Homo sapiens | Q9NTX9 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | FAM217B | Homo sapiens | Q9NTX9 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | EFHC2 | Homo sapiens | Q5JST6 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | EFHC2 | Homo sapiens | Q5JST6 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | PRKAR1B | Homo sapiens | P31321 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | PRKAR1B | Homo sapiens | P31321 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | MEOX1 | Homo sapiens | P50221 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | MEOX1 | Homo sapiens | P50221 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | EIF4ENIF1 | Homo sapiens | Q9NRA8 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | EIF4ENIF1 | Homo sapiens | Q9NRA8 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | EIF4ENIF1 | Homo sapiens | Q9NRA8 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | STAM2 | Homo sapiens | O75886 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | STAM2 | Homo sapiens | O75886 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZBTB26 | Homo sapiens | Q9HCK0 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZBTB26 | Homo sapiens | Q9HCK0 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZBTB26 | Homo sapiens | Q9HCK0 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | MEAF6 | Homo sapiens | Q9HAF1 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | MEAF6 | Homo sapiens | Q9HAF1 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | TRIM42 | Homo sapiens | Q8IWZ5 | 25416956 | |
|
Intra
|
L3MBTL2 | Q969R5 | TRIM42 | Homo sapiens | Q8IWZ5 | 25416956 | |
|
Intra
|
L3MBTL2 | Q969R5 | TRIM42 | Homo sapiens | Q8IWZ5 | 25416956 | |
|
Intra
|
L3MBTL2 | Q969R5 | TAX1BP1 | Homo sapiens | Q86VP1 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | TAX1BP1 | Homo sapiens | Q86VP1 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | HDAC3 | Homo sapiens | O15379 | 20385135 | |
|
Intra
|
L3MBTL2 | Q969R5 | HDAC3 | Homo sapiens | O15379 | 20385135 | |
|
Intra
|
L3MBTL2 | Q969R5 | HDAC3 | Homo sapiens | O15379 | 20385135 | |
|
Intra
|
L3MBTL2 | Q969R5 | HDAC3 | Homo sapiens | O15379 | 20385135 | |
|
Intra
|
L3MBTL2 | Q969R5 | GOLGA2 | Homo sapiens | Q08379 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | GOLGA2 | Homo sapiens | Q08379 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | CCDC106 | Homo sapiens | Q9BWC9 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | CCDC106 | Homo sapiens | Q9BWC9 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | CCDC106 | Homo sapiens | Q9BWC9 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | HSF2BP | Homo sapiens | O75031 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | HSF2BP | Homo sapiens | O75031 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZFP64 | Homo sapiens | Q9NTW7 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZFP64 | Homo sapiens | Q9NTW7 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZFP64 | Homo sapiens | Q9NTW7 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | PAICS | Homo sapiens | P22234 | 25416956 | |
|
Intra
|
L3MBTL2 | Q969R5 | PAICS | Homo sapiens | P22234 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | PAICS | Homo sapiens | P22234 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | PAICS | Homo sapiens | P22234 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | TLE5 | Homo sapiens | Q08117 | 25416956 | |
|
Intra
|
L3MBTL2 | Q969R5 | TLE5 | Homo sapiens | Q08117 | 25416956 | |
|
Intra
|
L3MBTL2 | Q969R5 | TSPYL | Homo sapiens | Q6FI91 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | TSPYL | Homo sapiens | Q6FI91 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | THAP1 | Homo sapiens | Q9NVV9 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | THAP1 | Homo sapiens | Q9NVV9 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | THAP1 | Homo sapiens | Q9NVV9 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | CEP76 | Homo sapiens | Q8TAP6 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | CEP76 | Homo sapiens | Q8TAP6 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | GKAP1 | Homo sapiens | Q5VSY0 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | GKAP1 | Homo sapiens | Q5VSY0 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZBTB48 | Homo sapiens | P10074 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | ZBTB48 | Homo sapiens | P10074 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | STAC3 | Homo sapiens | Q96MF2 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | STAC3 | Homo sapiens | Q96MF2 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | STAC3 | Homo sapiens | Q96MF2 | 26871637 | |
|
Intra
|
L3MBTL2 | Q969R5 | STAC3 | Homo sapiens | Q96MF2 | 25416956 | |
|
Intra
|
L3MBTL2 | Q969R5 | TNNI1 | Homo sapiens | P19237 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | TNNI1 | Homo sapiens | P19237 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | AMOTL2 | Homo sapiens | Q9Y2J4 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | AMOTL2 | Homo sapiens | Q9Y2J4 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | AMOTL2 | Homo sapiens | Q9Y2J4 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | MAX | Homo sapiens | P61244 | 25609649 | |
|
Intra
|
L3MBTL2 | Q969R5 | MAX | Homo sapiens | P61244 | 25609649 | |
|
Intra
|
L3MBTL2 | Q969R5 | MAX | Homo sapiens | P61244 | 33961781 | |
|
Intra
|
L3MBTL2 | Q969R5 | MAX | Homo sapiens | P61244 | 24981860 | |
|
Intra
|
L3MBTL2 | Q969R5 | MAX | Homo sapiens | P61244 | 27705803 | |
|
Intra
|
L3MBTL2 | Q969R5 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | TRIM50 | Homo sapiens | Q86XT4 | 32296183 | |
|
Intra
|
L3MBTL2 | Q969R5 | TRIM50 | Homo sapiens | Q86XT4 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Idh-Mutant Anaplastic Astrocytoma |
|
|
| Idh-Wildtype Anaplastic Astrocytoma |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS07485 | L3MBTL2 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | L3MBTL2 | VGNC | VGNC:42558 |
| Felis catus | L3MBTL2 | VGNC | VGNC:63182 |
| Macaca mulatta | L3MBTL2 | VGNC | VGNC:74074 |
| Bos taurus | L3MBTL2 | VGNC | VGNC:30763 |
| Mus musculus | L3MBTL2 | MGD | MGI:2443584 |
| Rattus norvegicus | L3MBTL2 | RGD | RGD:1308569 |
| Others | L3MBTL2 | NCBI |
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