STAM2 - signal transducing adaptor molecule 2 Gene

Also Known as Hbp; STAM2A; STAM2B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10254

About STAM2

Cytogenetic location: 2q23.3 Genomic coordinates (GRCh38): 2:152,116,801-152,175,763 (from NCBI)

This gene has 6 transcripts (splice variants), 222 orthologues and 10 paralogues. Ubiquitous expression in testis (RPKM 10.8), thyroid (RPKM 10.4) and 25 other tissues.

Summary

The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of Cytokine Receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]

STAM2 Products (1)

mRNA Protein Name
NM_005843.6 NP_005834.4 signal transducing adapter molecule 2

STAM2 Protein Structure

VHS

VHS: VHS domain (6 - 140)

UIM

UIM: Ubiquitin interaction motif (164 - 181)

SH3_1

SH3_1: SH3 domain (208 - 253)

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  • 500
  • 525 a.a.
Protein Preferred Names Protein Names

signal transducing adapter molecule 2

  • HSE1 homolog

STAM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STAM2 O75886 SH2D4A Homo sapiens Q9H788-2
Y2H Prey Pooling
25416956
Intra
STAM2 O75886 SH2D4A Homo sapiens Q9H788-2
Validated Y2H
25416956
Intra
STAM2 O75886 SH2D4A Homo sapiens Q9H788-2
Y2H Array
25416956
Intra
STAM2 O75886 TIMM8A Homo sapiens O60220
Y2H Prey Pooling
25416956
Intra
STAM2 O75886 TIMM8A Homo sapiens O60220
Y2H Array
25416956
Intra
STAM2 O75886 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
STAM2 O75886 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
STAM2 O75886 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
STAM2 O75886 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
STAM2 O75886 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
STAM2 O75886 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
STAM2 O75886 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
STAM2 O75886 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
STAM2 O75886 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
STAM2 O75886 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
STAM2 O75886 COL26A1 Homo sapiens Q96A83-2
Y2H Array
32814053
Intra
STAM2 O75886 COL26A1 Homo sapiens Q96A83-2
Validated Y2H
32814053
Intra
STAM2 O75886 COL26A1 Homo sapiens Q96A83-2
Y2H Pooling
32814053
Intra
STAM2 O75886 VPS37C Homo sapiens A5D8V6
Validated Y2H
25416956
Intra
STAM2 O75886 VPS37C Homo sapiens A5D8V6
Y2H Array
25416956
Intra
STAM2 O75886 DCTN1 Homo sapiens Q14203-5
Validated Y2H
32814053
Intra
STAM2 O75886 DCTN1 Homo sapiens Q14203-5
Y2H Array
32814053
Intra
STAM2 O75886 DCTN1 Homo sapiens Q14203-5
Y2H Pooling
32814053
Intra
STAM2 O75886 NUP58 Homo sapiens Q9BVL2
Validated Y2H
32814053
Intra
STAM2 O75886 NUP58 Homo sapiens Q9BVL2
Y2H Array
32814053
Intra
STAM2 O75886 NUP58 Homo sapiens Q9BVL2
Y2H Pooling
32814053
Intra
STAM2 O75886 ARRDC3 Homo sapiens Q96B67
Validated Y2H
32296183
Intra
STAM2 O75886 ARRDC3 Homo sapiens Q96B67
Y2H Prey Pooling
25416956
Intra
STAM2 O75886 LCP2 Homo sapiens Q13094
Peptide Array
17235283
Intra
STAM2 O75886 LCP2 Homo sapiens Q13094
Y2H Prey Pooling
25416956
Intra
STAM2 O75886 LCP2 Homo sapiens Q13094
Validated Y2H
32296183
Intra
STAM2 O75886 LCP2 Homo sapiens Q13094
Y2H Array
25416956
Intra
STAM2 O75886 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
STAM2 O75886 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
STAM2 O75886 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
STAM2 O75886 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
STAM2 O75886 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
STAM2 O75886 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
STAM2 O75886 CCT5 Homo sapiens P48643
Y2H Array
32814053
Intra
STAM2 O75886 CCT5 Homo sapiens P48643
Y2H Pooling
32814053
Intra
STAM2 O75886 CCT5 Homo sapiens P48643
Validated Y2H
32814053
Intra
STAM2 O75886 PLEKHB2 Homo sapiens Q96CS7
Validated Y2H
32296183
Intra
STAM2 O75886 PLEKHB2 Homo sapiens Q96CS7
Y2H Array
25416956
Intra
STAM2 O75886 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
STAM2 O75886 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
STAM2 O75886 RNF11 Homo sapiens Q9Y3C5
Y2H
15231748
Intra
STAM2 O75886 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
STAM2 O75886 STAMBP Homo sapiens O95630
NMR
27725184
Intra
STAM2 O75886 STAMBP Homo sapiens O95630
Y2H
16730941
Intra
STAM2 O75886 STAMBP Homo sapiens O95630
Y2H Array
31515488
Intra
STAM2 O75886 STAMBP Homo sapiens O95630
Y2H Pooling
16189514
Intra
STAM2 O75886 UBB Homo sapiens P0CG47
Validated Y2H
32814053
Intra
STAM2 O75886 UBB Homo sapiens P0CG47
Y2H Array
32814053
Intra
STAM2 O75886 UBB Homo sapiens P0CG47
Y2H Pooling
32814053
Intra
STAM2 O75886 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
STAM2 O75886 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
STAM2 O75886 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
STAM2 O75886 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
STAM2 O75886 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
STAM2 O75886 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
STAM2 O75886 DAZAP2 Homo sapiens Q15038
Y2H Array
25416956
Intra
STAM2 O75886 DAZAP2 Homo sapiens Q15038
Validated Y2H
32296183
Intra
STAM2 O75886 LITAF Homo sapiens Q99732
Y2H Prey Pooling
25416956
Intra
STAM2 O75886 LITAF Homo sapiens Q99732
Y2H Array
31515488
Intra
STAM2 O75886 LITAF Homo sapiens Q99732
Validated Y2H
25416956
Intra
STAM2 O75886 LITAF Homo sapiens Q99732
Validated Y2H
32296183
Intra
STAM2 O75886 LITAF Homo sapiens Q99732
Y2H Array
25416956
Intra
STAM2 O75886 KLHL42 Homo sapiens Q9P2K6
Validated Y2H
32296183
Intra
STAM2 O75886 KLHL42 Homo sapiens Q9P2K6
Y2H Prey Pooling
25416956
Intra
STAM2 O75886 L3MBTL2 Homo sapiens Q969R5
Validated Y2H
32296183
Intra
STAM2 O75886 L3MBTL2 Homo sapiens Q969R5
Y2H Pooling
16189514
Intra
STAM2 O75886 HGS Homo sapiens O14964
Anti Tag CoIP
35271311
Intra
STAM2 O75886 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
STAM2 O75886 ZC3H10 Homo sapiens Q96K80
Validated Y2H
32296183
Intra
STAM2 O75886 ABI2 Homo sapiens Q9NYB9
Y2H Array
29892012
Intra
STAM2 O75886 SH2D4A Homo sapiens Q9H788
Y2H Prey Pooling
25416956
Intra
STAM2 O75886 SH2D4A Homo sapiens Q9H788
Y2H Array
25416956
Intra
STAM2 O75886 q8wu02_human Homo sapiens Q8WU02
Validated Y2H
25416956
Intra
STAM2 O75886 q8wu02_human Homo sapiens Q8WU02
Y2H Prey Pooling
25416956
Intra
STAM2 O75886 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra
STAM2 O75886 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
STAM2 O75886 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra
STAM2 O75886 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
STAM2 O75886 ATXN1 Homo sapiens P54253
Y2H Prey Pooling
23275563
Intra
STAM2 O75886 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
STAM2 O75886 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
STAM2 O75886 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
STAM2 O75886 SNCA Homo sapiens P37840
Validated Y2H
32814053
Intra
STAM2 O75886 SNCA Homo sapiens P37840
Y2H Pooling
32814053
Intra
STAM2 O75886 SNCA Homo sapiens P37840
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13870 STAM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus STAM2 MGD MGI:1929100
Felis catus STAM2 VGNC VGNC:65746
Canis familiaris STAM2 VGNC VGNC:46876
Bos taurus STAM2 VGNC VGNC:97314
Macaca mulatta STAM2 VGNC VGNC:77903
Rattus norvegicus STAM2 RGD RGD:1311497
Others STAM2 NCBI