STAMBP - STAM binding protein Gene

Also Known as AMSH; MICCAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10617

About STAMBP

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:73,828,961-73,873,656 (from NCBI)

This gene has 71 transcripts (splice variants), 209 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 4.9), brain (RPKM 4.5) and 25 other tissues.

Summary

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

STAMBP Products (13)

mRNA Protein Name
NM_001353967.2 NP_001340896.1 STAM-binding protein isoform 1
NM_001353968.2 NP_001340897.1 STAM-binding protein isoform 1
NM_001353969.2 NP_001340898.1 STAM-binding protein isoform 2
NM_001353970.2 NP_001340899.1 STAM-binding protein isoform 2
NM_001353971.2 NP_001340900.1 STAM-binding protein isoform 3
NM_001353972.2 NP_001340901.1 STAM-binding protein isoform 3
NM_001353973.2 NP_001340902.1 STAM-binding protein isoform 3
NM_001353974.2 NP_001340903.1 STAM-binding protein isoform 3
NM_001353975.2 NP_001340904.1 STAM-binding protein isoform 3
NM_001353976.2 NP_001340905.1 STAM-binding protein isoform 4
NM_006463.6 NP_006454.1 STAM-binding protein isoform 1
NM_201647.4 NP_964010.1 STAM-binding protein isoform 1
NM_213622.4 NP_998787.1 STAM-binding protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables K63-linked deubiquitinase activity IDA
IDA: Inferred from direct assay
34425109 GOA
enables deubiquitinase activity IDA
IDA: Inferred from direct assay
18388320 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10383417 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
18395747 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within mitotic cytokinesis IMP
IMP: Inferred from mutant phenotype
18388320 GOA
involved in negative regulation of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
23542699 GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
23542699 GOA
acts upstream of or within protein deubiquitination IMP
IMP: Inferred from mutant phenotype
18388320 GOA
Cellular Component GO Annotation Evidence References Source
located in cleavage furrow IDA
IDA: Inferred from direct assay
18388320 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAMBP Protein Structure

USP8_dimer

USP8_dimer: USP8 dimerisation domain (13 - 116)

JAB

JAB: JAB1/Mov34/MPN/PAD-1 ubiquitin protease (254 - 360)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 424 a.a.
Protein Preferred Names Protein Names

STAM-binding protein

  • associated molecule with the SH3 domain of STAM

STAMBP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STAMBP O95630 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
STAMBP O95630 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
STAMBP O95630 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
STAMBP O95630 CHMP1A Homo sapiens Q9HD42
Anti Tag CoIP
17711858
Intra
STAMBP O95630 CHMP1A Homo sapiens Q9HD42
Y2H
17711858
Intra
STAMBP O95630 CHMP1A Homo sapiens Q9HD42
Anti Tag CoIP
33961781
Intra
STAMBP O95630 CHMP1A Homo sapiens Q9HD42
Anti Tag CoIP
28514442
Intra
STAMBP O95630 APOBEC3A Homo sapiens P31941
Validated Y2H
32296183
Intra
STAMBP O95630 BMP2K Homo sapiens Q9NSY1
Anti Tag CoIP
33961781
Intra
STAMBP O95630 BMP2K Homo sapiens Q9NSY1
Anti Tag CoIP
28514442
Intra
STAMBP O95630 CHMP3 Homo sapiens Q9Y3E7-1
Pull Down
21827950
Intra
STAMBP O95630 CHMP1B Homo sapiens Q7LBR1
Y2H
21988832
Intra
STAMBP O95630 CHMP1B Homo sapiens Q7LBR1
Y2H
16730941
Intra
STAMBP O95630 CHMP1B Homo sapiens Q7LBR1
Y2H Prey Pooling
25416956
Intra
STAMBP O95630 CHMP1B Homo sapiens Q7LBR1
Validated Y2H
25416956
Intra
STAMBP O95630 CHMP1B Homo sapiens Q7LBR1
Pull Down
21827950
Intra
STAMBP O95630 CHMP1B Homo sapiens Q7LBR1
Validated Y2H
32296183
Intra
STAMBP O95630 CHMP1B Homo sapiens Q7LBR1
SPR
21827950
Intra
STAMBP O95630 CHMP3 Homo sapiens Q9Y3E7
Anti Tag CoIP
28514442
Intra
STAMBP O95630 CHMP3 Homo sapiens Q9Y3E7
Y2H Prey Pooling
25416956
Intra
STAMBP O95630 CHMP3 Homo sapiens Q9Y3E7
Y2H
16730941
Intra
STAMBP O95630 CHMP3 Homo sapiens Q9Y3E7
Pull Down
17711858
Intra
STAMBP O95630 CHMP3 Homo sapiens Q9Y3E7
Anti Tag CoIP
19615732
Intra
STAMBP O95630 CHMP3 Homo sapiens Q9Y3E7
Y2H
17711858
Intra
STAMBP O95630 PRKN Homo sapiens O60260-5
Validated Y2H
32814053
Intra
STAMBP O95630 PRKN Homo sapiens O60260-5
Y2H Array
32814053
Intra
STAMBP O95630 PRKN Homo sapiens O60260-5
Y2H Pooling
32814053
Intra
STAMBP O95630 CHMP2A Homo sapiens O43633
Anti Tag CoIP
33961781
Intra
STAMBP O95630 CHMP2A Homo sapiens O43633
Anti Tag CoIP
28514442
Intra
STAMBP O95630 CCT5 Homo sapiens P48643
Validated Y2H
32814053
Intra
STAMBP O95630 CCT5 Homo sapiens P48643
Y2H Array
32814053
Intra
STAMBP O95630 CCT5 Homo sapiens P48643
Y2H Pooling
32814053
Intra
STAMBP O95630 TRIP13 Homo sapiens Q15645
Y2H Array
31515488
Intra
STAMBP O95630 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
Intra
STAMBP O95630 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
Intra
STAMBP O95630 TARDBP Homo sapiens Q13148
Y2H Array
32814053
Intra
STAMBP O95630 STAM2 Homo sapiens O75886
Y2H Pooling
19060904
Intra
STAMBP O95630 STAM2 Homo sapiens O75886
Y2H Array
19060904
Intra
STAMBP O95630 RNF11 Homo sapiens Q9Y3C5
Anti Tag CoIP
14755250
Intra
STAMBP O95630 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
STAMBP O95630 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
STAMBP O95630 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
STAMBP O95630 RNF11 Homo sapiens Q9Y3C5
Y2H
14755250
Intra
STAMBP O95630 GRB2 Homo sapiens P62993
Y2H Array
25416956
Intra
STAMBP O95630 GRB2 Homo sapiens P62993
Y2H Prey Pooling
25416956
Intra
STAMBP O95630 GRB2 Homo sapiens P62993
Anti Tag CoIP
19615732
Intra
STAMBP O95630 UBB Homo sapiens P0CG47
Validated Y2H
32814053
Intra
STAMBP O95630 UBB Homo sapiens P0CG47
Y2H Pooling
32814053
Intra
STAMBP O95630 UBB Homo sapiens P0CG47
Y2H Array
32814053
Intra
STAMBP O95630 SMAD6 Homo sapiens O43541-2
Y2H
11483516
Intra
STAMBP O95630 CHMP5 Homo sapiens Q9NZZ3
Y2H
21988832
Intra
STAMBP O95630 STAM Homo sapiens Q92783
ITC
17078930
Intra
STAMBP O95630 STAM Homo sapiens Q92783
Anti Tag CoIP
10383417
Intra
STAMBP O95630 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
STAMBP O95630 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
STAMBP O95630 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

STAMBP Antibodies

Cat. No. Product Name Application Reactivity
HY-P82962 AMSH Antibody (YA2707) WB Human
HY-P82962A AMSH Antibody (YA2707)(PBS only) WB Human

Related Diseases

Diseases Alias
Microcephaly-Capillary Malformation Syndrome

  • Mic-Cap Syndrome

  • MICCAP

  • Mic-Cm Syndrome

  • Microcephaly-Cutaneous Capillary Malformation Syndrome
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome

  • Jacobs Syndrome

  • Arthropathy-Camptodactyly Syndrome

  • Pericarditis-Arthropathy-Camptodactyly Syndrome

  • Xyy Syndrome

  • Pac Syndrome

  • Cacp Syndrome

  • CACP

  • Fibrosing Serositis, Familial

  • Camptodactyly-Arthropathy-Pericarditis Syndrome

  • Cap Syndrome

  • 47, Xyy Syndrome

  • 47,Xyy Syndrome

  • Double Y Syndrome

  • Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome

  • Hypertrophic Synovitis, Congenital Familial

  • Congenital Familial Hypertrophic Synovitis

  • Xyy Karyotype

  • Y Disomy

  • Yy Syndrome

  • Familial Fibrosing Serositis

  • Disomy Y

  • Double Y

  • Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome

  • Arthropathy Camptodactyly Syndrome

  • Camptodactyly Arthropathy Pericarditis Syndrome

  • Pericarditis Arthropathy Camptodactyly Syndrome

  • Jacob'S Syndrome

  • 47,Xyy

  • Cdags Syndrome
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122883 BC-1471 Inhibitor 99.69% Unkown
HY-141852 STAMBP-IN-1 Inhibitor 98.73% Unkown
HY-RS13871 STAMBP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18718 Stambp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25205 Stambp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta STAMBP VGNC VGNC:77935
Rattus norvegicus STAMBP RGD RGD:619963
Mus musculus STAMBP MGD MGI:1917777
Bos taurus STAMBP VGNC VGNC:35356
Felis catus STAMBP VGNC VGNC:65747
Others STAMBP NCBI