STAMBP - STAM binding protein Gene

Homo sapiens

Also known as AMSH; MICCAP

Gene ID: 10617 | Gene type: protein coding

About STAMBP

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:73,828,961-73,873,656 (from NCBI)

This gene has 71 transcripts (splice variants), 209 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 4.9), brain (RPKM 4.5) and 25 other tissues.

Summary

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

STAMBP Products(13)

mRNA	Protein	Name
NM_001353967.2	NP_001340896.1	STAM-binding protein isoform 1
NM_001353968.2	NP_001340897.1	STAM-binding protein isoform 1
NM_001353969.2	NP_001340898.1	STAM-binding protein isoform 2
NM_001353970.2	NP_001340899.1	STAM-binding protein isoform 2
NM_001353971.2	NP_001340900.1	STAM-binding protein isoform 3
NM_001353972.2	NP_001340901.1	STAM-binding protein isoform 3
NM_001353973.2	NP_001340902.1	STAM-binding protein isoform 3
NM_001353974.2	NP_001340903.1	STAM-binding protein isoform 3
NM_001353975.2	NP_001340904.1	STAM-binding protein isoform 3
NM_001353976.2	NP_001340905.1	STAM-binding protein isoform 4
NM_006463.6	NP_006454.1	STAM-binding protein isoform 1
NM_201647.4	NP_964010.1	STAM-binding protein isoform 1
NM_213622.4	NP_998787.1	STAM-binding protein isoform 1

STAMBP Protein Structure

USP8_dimer

JAB

0
100
200
300
400
424 a.a.

Protein Preferred Names

Protein Names

STAM-binding protein

associated molecule with the SH3 domain of STAM

Related Diseases

Diseases

Alias

Microcephaly-Capillary Malformation Syndrome

Mic-Cap Syndrome	MICCAP
Mic-Cm Syndrome	Microcephaly-Cutaneous Capillary Malformation Syndrome

Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome

Jacobs Syndrome	Arthropathy-Camptodactyly Syndrome
Pericarditis-Arthropathy-Camptodactyly Syndrome	Xyy Syndrome
Pac Syndrome	Cacp Syndrome
CACP	Fibrosing Serositis, Familial
Camptodactyly-Arthropathy-Pericarditis Syndrome	Cap Syndrome
47, Xyy Syndrome	47,Xyy Syndrome
Double Y Syndrome	Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome
Hypertrophic Synovitis, Congenital Familial	Congenital Familial Hypertrophic Synovitis
Xyy Karyotype	Y Disomy
Yy Syndrome	Familial Fibrosing Serositis
Disomy Y	Double Y
Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome	Arthropathy Camptodactyly Syndrome
Camptodactyly Arthropathy Pericarditis Syndrome	Pericarditis Arthropathy Camptodactyly Syndrome
Jacob'S Syndrome	47,Xyy
Cdags Syndrome

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122883	BC-1471	Inhibitor	99.89%	Unkown
HY-141852	STAMBP-IN-1	Inhibitor	98.37%	Unkown
HY-RS13871	STAMBP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	STAMBP	VGNC	VGNC:77935
Rattus norvegicus	STAMBP	RGD	RGD:619963
Mus musculus	STAMBP	MGD	MGI:1917777
Bos taurus	STAMBP	VGNC	VGNC:35356
Felis catus	STAMBP	VGNC	VGNC:65747
Others	STAMBP	NCBI

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