BMP2K - BMP2 inducible kinase Gene

Also Known as BIKE; HRIHFB2017

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55589

About BMP2K

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:78,776,350-78,916,365 (from NCBI)

This gene has 6 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 10.8), lymph node (RPKM 10.8) and 25 other tissues.

Summary

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BMP2K Products (2)

mRNA	Protein	Name
NM_017593.5	NP_060063.2	BMP-2-inducible protein kinase isoform b
NM_198892.2	NP_942595.1	BMP-2-inducible protein kinase isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMP2K Protein Structure

Pkinase

BMP2K_C

0
200
400
600
800
1000
1161 a.a.

Protein Preferred Names	Protein Names
BMP-2-inducible protein kinase

BMP2K Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BMP2K	Q9NSY1	CLINT1	Homo sapiens	Q14677	BFG-2H	35452674
Intra	BMP2K	Q9NSY1	CLINT1	Homo sapiens	Q14677	Protein Kinase Assay	35452674
Intra	BMP2K	Q9NSY1	CLINT1	Homo sapiens	Q14677	Anti Tag CoIP	35452674
Intra	BMP2K	Q9NSY1	CLINT1	Homo sapiens	Q14677	SLC	35452674
Intra	BMP2K	Q9NSY1	STAMBP	Homo sapiens	O95630	SLC	35452674

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mixed Phenotype Acute Leukemia, B/Myeloid	Doid:0081038
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-123940	SGC-AAK1-1	Inhibitor	98.47%	Unkown
HY-147083	SGC-AAK1-1N	Inhibitor	97.9%	Unkown
HY-162653	SGC-CDKL2/AAK1/BMP2K-1		98.55%	Unkown
HY-RS01537	BMP2K Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181293	PROTAC AAK1 degrader-1	Degrader	/	Unkown
HY-RS17130	Bmp2k Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23575	Bmp2k Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BMP2K	VGNC	VGNC:100203
Bos taurus	BMP2K	VGNC	VGNC:106651
Rattus norvegicus	BMP2K	RGD	RGD:1564828
Felis catus	BMP2K	VGNC	VGNC:60131
Mus musculus	BMP2K	MGD	MGI:2155456
Canis familiaris	BMP2K	VGNC	VGNC:38479
Others	BMP2K	NCBI