2. Gene
  3. BMP2K - BMP2 inducible kinase Gene

BMP2K - BMP2 inducible kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BIKE; HRIHFB2017

Gene ID: 55589 | Gene type: protein coding

About BMP2K

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:78,776,350-78,916,365 (from NCBI)

This gene has 6 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 10.8), lymph node (RPKM 10.8) and 25 other tissues.

Summary

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BMP2K Products(2)

mRNA Protein Name
NM_017593.5 NP_060063.2 BMP-2-inducible protein kinase isoform b
NM_198892.2 NP_942595.1 BMP-2-inducible protein kinase isoform a

BMP2K Protein Structure

Pkinase

Pkinase: Protein kinase domain (52 - 311)

BMP2K_C

BMP2K_C: BMP-2-inducible protein kinase C-terminus (892 - 1161)

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  • 1161 a.a.
Protein Preferred Names Protein Names

BMP-2-inducible protein kinase

Related Diseases

Diseases Alias
Mixed Phenotype Acute Leukemia, B/Myeloid

Doid:0081038
Myopia

Near-Sightedness

Short-Sightedness

Nearsightedness

Nearsighted

Near Vision

Close Sighted

Myopic

Short-Sighted

Near Sighted
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136848 SM1-71 Inhibitor 96.00% Unkown
HY-123940 SGC-AAK1-1 98.93% Unkown
HY-148063 DB0614 98.80% Unkown
HY-147083 SGC-AAK1-1N Inhibitor / Unkown
HY-RS01537 BMP2K Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BMP2K VGNC VGNC:100203
Bos taurus BMP2K VGNC VGNC:106651
Rattus norvegicus BMP2K RGD RGD:1564828
Felis catus BMP2K VGNC VGNC:60131
Mus musculus BMP2K MGD MGI:2155456
Canis familiaris BMP2K VGNC VGNC:38479