1. Stem Cell/Wnt
  2. Wnt
  3. SGC-AAK1-1

SGC-AAK1-1 

Cat. No.: HY-123940
Handling Instructions

SGC-AAK1-1, a chemical probe, is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC50 of 270 nM and a Ki of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1.

For research use only. We do not sell to patients.

SGC-AAK1-1 Chemical Structure

SGC-AAK1-1 Chemical Structure

CAS No. : 2247894-32-0

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Description

SGC-AAK1-1, a chemical probe, is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC50 of 270 nM and a Ki of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1[1].

IC50 & Target

IC50: 270 nM (AAK1)[1].
Ki: 9 nM (AAK1)[1]

In Vitro

SGC-AAK1-1 (1.25 μM) significantly reduces phosphorylation of AP2M1 (T156) and activates WNT-driven BAR activity compared in a dose-dependent manner in HT1080 cells[1].
SGC-AAK1-1 blocks AAK1 kinase activity, resulting in increased β-catenin protein stability and β-catenin-dependent transcription[1].

Molecular Weight

427.52

Formula

C₂₁H₂₅N₅O₃S

CAS No.

2247894-32-0

SMILES

O=C(C1CC1)NC2=NNC3=C2C=CC(C4=CC=CC(NS(=O)(N(CC)CC)=O)=C4)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SGC-AAK1-1WntInhibitorinhibitorinhibit

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