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Results for "

AAK1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AAK1 (20) Aurora Kinase (1) CaMK (1) CDK (2) Cyclin G-associated Kinase (GAK) (3) Ferroptosis (1) FGFR (1) LIM Kinase (LIMK) (3) MAP3K (1) Pim (1) PROTACs (3) Ribosomal S6 Kinase (RSK) (1) Salt-inducible Kinase (SIK) (2) SARS-CoV (2) Small Interfering RNA (siRNA) (3) Src (1) ULK (1) Wee1 (2)
By Research Areas:	Cancer (5) Infection (2) Inflammation/Immunology (1) Neurological Disease (15)

Targets Recommended: AAK1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS00020

AAK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AAK1 Human Pre-designed siRNA Set A contains three designed siRNAs for AAK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AAK1 Human Pre-designed siRNA Set A AAK1 Human Pre-designed siRNA Set A

HY-RS00021

Aak1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Aak1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aak1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aak1 Mouse Pre-designed siRNA Set A Aak1 Mouse Pre-designed siRNA Set A

HY-RS00022

Aak1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Aak1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Aak1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aak1 Rat Pre-designed siRNA Set A Aak1 Rat Pre-designed siRNA Set A

HY-144301

AAK1-IN-2	AAK1	Neurological Disease
AAK1-IN-2 (compound (S)-31) is a potent, selective and brain-penetrant inhibitor of Adaptor Protein 2-Associated Kinase 1 (AAK1), with an IC₅₀ of 5.8 nM. AAK1-IN-2 can be used for the research of neuropathic pain ^[1].

HY-145838

AAK1-IN-4	AAK1	Neurological Disease
AAK1-IN-4 is a highly selective, CNS-penetrable, and orally active adaptor protein-2-associated kinase 1 *(AAK1)* inhibitor (AAK1 IC₅₀ of 4.6 nM, Filt K_i of 0.9 nM, and cell IC₅₀ of 8.6 nM). AAK1-IN-4 has the potential for the research for neuropathic pain ^[1].

HY-145839

AAK1-IN-5	AAK1	Neurological Disease
AAK1-IN-5 is a highly selective, CNS-penetrable, and orally active adaptor protein-2-associated kinase 1 *(AAK1)* inhibitor (AAK1 IC₅₀ of 1.2 nM, Filt K_i of 0.05 nM, and cell IC₅₀ of 0.5 nM). AAK1-IN-4 has the potential for the research for neuropathic pain ^[1].

HY-144301A

AAK1-IN-2 TFA	AAK1	Neurological Disease
AAK1-IN-2 TFA (compound (S)-31) is a potent, selective and brain-penetrant inhibitor of Adaptor Protein 2-Associated Kinase 1 (AAK1), with an IC₅₀ of 5.8 nM. AAK1-IN-2 TFA can be used for the research of neuropathic pain ^[1].

HY-144302

AAK1-IN-3	AAK1	Neurological Disease
AAK1-IN-3, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC₅₀ of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research ^[1].

HY-144302A

AAK1-IN-3 TFA	AAK1	Neurological Disease
AAK1-IN-3 TFA, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC₅₀ of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research ^[1].

HY-134829

BMS-986176 LX-9211; AAK1-IN-1	AAK1	Neurological Disease
BMS-986176 (LX-9211) is a highly selective, brain-penetrant, potent AAK1 (adaptor associated kinase 1) inhibitor with an IC₅₀ of 2 nM. BMS-986176 can be used for neurodegenerative diseases research ^[1].

HY-123940

*SGC-AAK1-1*	AAK1	Cancer
SGC-AAK1-1 is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC₅₀ of 270 nM and a K_i of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1 ^[1].

HY-147083

SGC-AAK1-1N

AAK1 Cancer

SGC-AAK1-1N is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor, with an IC₅₀ of 1.8 μM ^[1].
HY-117453

BMS-901715

AAK1 Neurological Disease

BMS-901715 is a potent and selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC₅₀ of 3.3 nM ^[1] .

*SGC-AAK1-1N*	AAK1	Cancer
SGC-AAK1-1N is a potent and selective *AAK1* (AP2 associated kinase 1) inhibitor, with an IC₅₀ of 1.8 μM ^[1].

BMS-901715	AAK1	Neurological Disease
BMS-901715 is a potent and selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC₅₀ of 3.3 nM ^[1] .

HY-162388

TIM-098a	AAK1	Neurological Disease
TIM-098a is a selective *AAK1* inhibitor with an IC₅₀ of 0.24 µM. TIM-098a has no inhibitory activity against CaMKK isoforms. TIM-098a inhibits AAK1-regulated endocytosis by suppressing AAK1 kinase activity ^[1].

HY-161261

SARS-CoV-2-IN-81	AAK1 SARS-CoV	Infection
SARS-CoV-2-IN-81 (compound 12e) is a potent *AAK1* inhibitor with an IC₅₀ value of 9.38 nM. SARS-CoV-2-IN-81 shows anti-viral property against SARS-CoV-2. SARS-CoV-2-IN-81 attenuates AAK1-induced phosphorylation of AP2M1 threonine 156 and disrupts the direct interaction between AP2M1 and ACE2, ultimately inhibiting SARS-CoV-2 infection ^[1].

HY-115868

BMS-911172

AAK1 Neurological Disease

BMS-911172 is an adaptor associated kinase 1 (AAK1 kinase) inhibitor (IC₅₀ = 35 nM).

BMS-911172	AAK1	Neurological Disease
BMS-911172 is an *adaptor associated kinase 1 (AAK1* kinase) inhibitor (IC₅₀** = 35 nM).

HY-120179

LP-922761	AAK1	Neurological Disease
LP-922761 is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC₅₀s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) with an IC₅₀ of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors ^[1].

HY-120179A

LP-922761 hydrate	AAK1	Neurological Disease
LP-922761 hydrate is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC₅₀s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 hydrate also inhibits BMP-2-inducible protein kinase (BIKE) with an IC₅₀ of 24 nM. LP-922761 hydrate shows less activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors ^[1].

HY-135871

BMT-124110	AAK1	Neurological Disease
BMT-124110 is a potent, selective *AAK1* inhibitor with an IC₅₀ of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC₅₀s of 17 and 99 nM, respectively ^[1].

HY-148065

FMF-06-098-1	PROTACs	Cancer
FMF-06-098-1 is a multitargeted depressant. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 ^[1].

HY-136848

SM1-71	MAP3K Src FGFR Ribosomal S6 Kinase (RSK) LIM Kinase (LIMK)	Cancer
SM1-71 (compound 5) is a potent *TAK1* inhibitor, with a K_i of 160 nM, it also can covalently inhibit MKNK2, *MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1* and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines ^[1] .

HY-101290

BMT-090605
BMT-090605 is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC₅₀ value of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC₅₀ values of 45 nM and 60 nM, respectively. BMT-090605 can be used for the research of neuropathic pain ^[1].

HY-101290A

BMT-090605 hydrochloride	Cyclin G-associated Kinase (GAK) AAK1	Neurological Disease
BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC₅₀ value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC₅₀ values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain ^[1].

HY-117626

LP-935509	AAK1 Cyclin G-associated Kinase (GAK) SARS-CoV	Infection Neurological Disease Inflammation/Immunology
LP-935509 is an orally active, potent, selective, ATP-competitive and brain-penetrant inhibitor of adaptor protein-2 associated kinase 1 (AAK1) with an IC₅₀ of 3.3 nM and a K_i of 0.9 nM, respectively. LP-935509 is also a potent inhibitor of BIKE (IC₅₀=14 nM) and a modest inhibitor of GAK (IC₅₀=320 nM). LP-935509 shows antinociceptive activity. LP-935509 can be used for neuropathic pain and SARS-CoV-2 research ^[1].

HY-148062

RSS0680	PROTACs CDK AAK1 Cyclin G-associated Kinase (GAK) Salt-inducible Kinase (SIK) LIM Kinase (LIMK) Wee1	Others
RSS0680 (Example 22) is a bifunctional compound targeted protein degradation of kinases. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used for research of disease or disorder mediated by aberrant kinase activity ^[1].

HY-148063

DB0614	PROTACs AAK1 Aurora Kinase CaMK CDK Ferroptosis Salt-inducible Kinase (SIK) ULK Wee1 LIM Kinase (LIMK)	Others
DB0614 (Example 21) is a bifunctional compound targeted protein degradation of kinases. DB0614 degrades AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity ^[1].

HY-10371

Pim1/AKK1-IN-1 4 Publications Verification LKB1/AAK1 dual inhibitor	Pim	Cancer
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with K_d values of 35 nM/53 nM/75 nM/380 nM for *Pim1/AKK1/MST2/LKB1* respectively, and also inhibits MPSK1 and TNIK.

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AAK1

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