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AAK1-IN-1 

Cat. No.: HY-134829
Handling Instructions

AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research.

For research use only. We do not sell to patients.

AAK1-IN-1 Chemical Structure

AAK1-IN-1 Chemical Structure

CAS No. : 1815613-42-3

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Description

AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research[1].

In Vitro

Adaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases. AAKl mRNA exists in two splice forms termed short and long. The long form predominates and is highly expressed in brain and heart. AAKl is enriched in synaptosomal preparations and is co-localized with endocytic structures in cultured cells. AAKl modulates clatherin coated endocytosis, a process that is important in synaptic vesicle recycling and receptor-mediated endocytosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

385.40

Formula

C₁₉H₂₃F₄N₃O

CAS No.
SMILES

CC(C)C[[email protected]@](N)(C)COC1=C(C(F)F)N=C(C2=CC(C(F)F)=NC=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AAK1-IN-1OthersAAK1neurodegenerativeInhibitorinhibitorinhibit

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