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BMT-124110 

Cat. No.: HY-135871
Handling Instructions

BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively.

For research use only. We do not sell to patients.

BMT-124110 Chemical Structure

BMT-124110 Chemical Structure

CAS No. : 1679371-59-5

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Description

BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively[1].

In Vitro

BMT-124110 shows a cellular IC50 of 3.2±1.4 nM for AAK1[1].

In Vivo

BMT-124110 is added directly onto the spinal corevd by microiontophoresis, leading to reduction in windup-induced activity in 10 of 14 animals[1].

Molecular Weight

369.46

Formula

C₂₁H₂₇N₃O₃

CAS No.

1679371-59-5

SMILES

CC(NC1=CC2=C(COC3=CC(OC[[email protected]@](C)(N)CC(C)C)=CC=C32)C=N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BMT-124110BMT124110BMT 124110OthersneuropathicpainchronicconstrictioninjuryCCIBIKEGAKInhibitorinhibitorinhibit

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BMT-124110
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