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LP-935509 

Cat. No.: HY-117626
Handling Instructions

LP-935509 is a small-molecule adapter protein-2 associated kinase 1 (AAK1) selective and brain-penetrantinhibitor (IC50=3.3 nM), a ATP-competitive inhibitor with a Ki of 0.9 nM. LP-935509 is a potent inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure.

For research use only. We do not sell to patients.

LP-935509 Chemical Structure

LP-935509 Chemical Structure

CAS No. : 1454555-29-3

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Description

LP-935509 is a small-molecule adapter protein-2 associated kinase 1 (AAK1) selective and brain-penetrantinhibitor (IC50=3.3 nM), a ATP-competitive inhibitor with a Ki of 0.9 nM. LP-935509 is a potent inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure[1].

IC50 & Target

IC50: 3.3 nM (AAK1); 14 nM (BIKE); 320 nM (GAK)[1]

Molecular Weight

396.44

Formula

C₂₀H₂₄N₆O₃

CAS No.

1454555-29-3

SMILES

O=C(N1CCN(C2=NC3=C(C4=CC=CN=C4OC)C=NN3C=C2)CC1)OC(C)C

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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LP-935509
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HY-117626
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