GAK
GAK (cyclin G-associated kinase) is a broadly expressed NAK-family kinase that functions as the mammalian counterpart of auxilin in clathrin-coated vesicle biology. Through a C-terminal J domain, GAK recruits Hsc70 to drive uncoating of clathrin from internalized vesicles, and its kinase domain phosphorylates the AP2 α subunit to influence adaptor function in both endocytosis and trans-Golgi trafficking. GAK localizes to the trans-Golgi network as well as coated pits and vesicles. Variants at the GAK locus are associated with Parkinson disease risk, linking clathrin machinery to α-synuclein handling. Recombinant GAK is used for uncoating, trafficking and kinase-inhibitor studies.
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GAK Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
