2. BMT-090605

BMT-090605 is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 can be used for the research of neuropathic pain.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (BMT-090605 hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

BMT-090605 Chemical Structure

BMT-090605 Chemical Structure

CAS No. : 1551403-51-0

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BMT-090605 Related Antibodies

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Description

BMT-090605 is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 can be used for the research of neuropathic pain[1].

IC50 & Target

IC50: 0.6 nM (AAK1); 45 nM (BIKE); 60 nM (GAK)[1]
In Vitro

BMT-090605 shows AAK1inhibitory activity with an IC50 of 0.63 nM[1].
BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMT-090605 Related Antibodies
In Vivo

BMT-090605 (intrathecal; 0.3-3 µg/rat) causes antinociception by inhibiting AAK1 in the spinal cord[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (chronic constriction injury (CCI) model)[1]
Dosage: 0.3-3 µg/rat
Administration: Intrathecal
Result: Caused a dose-dependent reduction in thermal hyperalgesia.
Molecular Weight

364.44

Formula

C21H24N4O2
CAS No.
SMILES

N#CC1=C(OC[C@@H](N)CC(C)C)C=C(C(C2=CC=NC(C)=C32)=C1)N(C)C3=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMT-0906051551403-51-0BMT090605BMT 090605Inhibitorinhibitorinhibit

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