BMT-090605 hydrochloride
Based on 1 Customer Validation
BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain.
For research use only. We do not sell to patients.
- Purity: 98.76%
- CAS No.: 2231664-45-0
- Formula: C21H25ClN4O2
- Molecular Weight:400.90
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 0.6 nM (AAK1); 45 nM (BIKE); 60 nM (GAK)[1]
BMT-090605 hydrochloride shows AAK1inhibitory activity with an IC50 of 0.63 nM[1].
BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats (chronic constriction injury (CCI) model)[1]
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Dosage:0.3-3 µg/rat
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Administration:Intrathecal
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Result:Caused a dose-dependent reduction in thermal hyperalgesia.
Chemical Information
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CAS No. 2231664-45-0
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Appearance Solid
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Molecular Weight 400.90
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Formula C21H25ClN4O2
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Color Light yellow to yellow
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SMILES
N#CC1=C(OC[C@@H](N)CC(C)C)C=C(C(C2=CC=NC(C)=C32)=C1)N(C)C3=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 31.25 mg/mL (77.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4944 mL | 12.4719 mL | 24.9439 mL | 62.3597 mL |
| 5 mM | 0.4989 mL | 2.4944 mL | 4.9888 mL | 12.4719 mL | |
| 10 mM | 0.2494 mL | 1.2472 mL | 2.4944 mL | 6.2360 mL | |
| 15 mM | 0.1663 mL | 0.8315 mL | 1.6629 mL | 4.1573 mL | |
| 20 mM | 0.1247 mL | 0.6236 mL | 1.2472 mL | 3.1180 mL | |
| 25 mM | 0.0998 mL | 0.4989 mL | 0.9978 mL | 2.4944 mL | |
| 30 mM | 0.0831 mL | 0.4157 mL | 0.8315 mL | 2.0787 mL | |
| 40 mM | 0.0624 mL | 0.3118 mL | 0.6236 mL | 1.5590 mL | |
| 50 mM | 0.0499 mL | 0.2494 mL | 0.4989 mL | 1.2472 mL | |
| 60 mM | 0.0416 mL | 0.2079 mL | 0.4157 mL | 1.0393 mL |
BMT-090605 hydrochloride Related Classifications
HY-101290A Related Classifications
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