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AAK1-IN-3 

Cat. No.: HY-144302
Handling Instructions

AAK1-IN-3, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC50 of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research.

For research use only. We do not sell to patients.

AAK1-IN-3 Chemical Structure

AAK1-IN-3 Chemical Structure

CAS No. : 1802703-20-3

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Description

AAK1-IN-3, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC50 of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research[1].

In Vitro

AAK1-IN-3 (compound (R)-31) is brain-penetrant kinase inhibitors with a B/P ratio of 1.3[1].
AAK1-IN-3 inhibits AAK1 in HEK293 cells (IC50=108 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AAK1-IN-3 (compound (R)-31; 30 mg/kg; sc; signle dose) causes a 46% reduction of μ2 phosphorylation in C57BL6 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

316.40

Formula

C20H20N4

CAS No.
SMILES

N#CC1=CC([[email protected]](N)CC(C)C)=NC2=CC=C(C3=CC=NC=C3)C=C12

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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AAK1-IN-3
Cat. No.:
HY-144302
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