SARS-CoV-2-IN-81
SARS-CoV-2-IN-81 (compound 12e) is a potent AAK1 inhibitor with an IC50 value of 9.38 nM. SARS-CoV-2-IN-81 shows anti-viral property against SARS-CoV-2. SARS-CoV-2-IN-81 attenuates AAK1-induced phosphorylation of AP2M1 threonine 156 and disrupts the direct interaction between AP2M1 and ACE2, ultimately inhibiting SARS-CoV-2 infection.
For research use only. We do not sell to patients.
- Formula: C25H20N4O2
- Molecular Weight:408.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IC50: 9.38 nM (AAK1)[1]
Chemical Information
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Molecular Weight 408.45
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Formula C25H20N4O2
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SMILES
C12=CC(C3=CN=C(NC=C4C#CC5=CN=CC=C5)C4=C3)=CC=C1N(CCOC6)C6CO2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)