2. Neuronal Signaling
  3. AAK1
  4. TIM-098a

TIM-098a is a selective AAK1 inhibitor with an IC50 of 0.24 µM. TIM-098a has no inhibitory activity against CaMKK isoforms. TIM-098a inhibits AAK1-regulated endocytosis by suppressing AAK1 kinase activity.

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TIM-098a Chemical Structure

TIM-098a Chemical Structure

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TIM-098a Related Antibodies

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Description

TIM-098a is a selective AAK1 inhibitor with an IC50 of 0.24 µM. TIM-098a has no inhibitory activity against CaMKK isoforms. TIM-098a inhibits AAK1-regulated endocytosis by suppressing AAK1 kinase activity[1].

IC50 & Target[1]

AAK1

0.24 μM (IC50)

GAK

1.04 μM (IC50)

BIKE

5.99 μM (IC50)

STK16

7.15 μM (IC50)

In Vitro

TIM-098a can inhibit AAK1 activity in transfected cultured cells (IC50=0.87 µM)[1].
TIM-098a (0.26, 0.82, 2.6, 26 μM; for 6 h) suppresses AAK1-catalyzed Thr156 phosphorylation of GST-AP2µ2 (145-162) in a concentration-dependent manner in AAK1/GST-AP2µ2 (145-162) expressing COS-7 cells[1].
TIM-098a (10 μM; for 6 h) recovers the number of early endosomes in AAK1-transfected cells to the level of untransfected wild type cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TIM-098a Related Antibodies
Molecular Weight

301.30

Formula

C18H11N3O2
SMILES

O=C(C1=CC=CC2=CC(O)=CC3=C12)N4C3=NC5=CC(N)=CC=C54
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TIM-098a Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TIM-098aAAK1Adaptor-associated Kinase 1AP2-associated kinase 1CaMKKendocytosisInhibitorinhibitorinhibit

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