PROTAC AAK1 degrader-1
PROTAC AAK1 degrader-1 (compound 14) is a selective PROTAC AAK1 degrader with a DC50 of <10 nM. PROTAC AAK1 degrader-1 does not significantly impact the levels of any other NAK family members, including BMP2K, GAK, and STK16. PROTAC AAK1 degrader-1 can be used in ovarian cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3113123-63-7
- Formula: C48H56F3N7O4
- Molecular Weight:852.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- References
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Biological Activity
PROTAC AAK1 Degrader-1 (1-100 nM, 1-24 h)’s effect on AAK1 protein levels is rapid, noticeable within one hour, and lasted for 3-4 days after 4-hour 14 treatment followed by extensive drug wash-off. PROTAC AAK1 Degrader-1 is also effective in reducing AAK1 levels in a panel of ovarian cancer cell lines including Taxane-resistant sublines (A2780- R and HEY-R) as well as various other cancer types[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3113123-63-7
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Molecular Weight 852.00
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Formula C48H56F3N7O4
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SMILES
CC(C[C@@H](COC1=CC=C(C=C1C(F)(F)F)C2=CC(NC3=CC=C(C=C3)C4CCN(CC4)CC5CCN(CC5)C6=CC7=C(C(N(C7)C8CCC(NC8=O)=O)=O)C=C6)=NC=C2)N)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC AAK1 degrader-1 Related Classifications
HY-181293 Related Classifications
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