PROTAC AAK1 degrader-1 

PROTAC AAK1 degrader-1 (compound 14) is a selective PROTAC AAK1 degrader with a DC₅₀ of <10 nM. PROTAC AAK1 degrader-1 does not significantly impact the levels of any other NAK family members, including BMP2K, GAK, and STK16. PROTAC AAK1 degrader-1 can be used in ovarian cancer research^[1].

PROTAC AAK1 Degrader-1 (1-100 nM, 1-24 h)’s effect on AAK1 protein levels is rapid, noticeable within one hour, and lasted for 3-4 days after 4-hour 14 treatment followed by extensive drug wash-off. PROTAC AAK1 Degrader-1 is also effective in reducing AAK1 levels in a panel of ovarian cancer cell lines including Taxane-resistant sublines (A2780- R and HEY-R) as well as various other cancer types^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

852.00

C₄₈H₅₆F₃N₇O₄

3113123-63-7

CC(C[C@@H](COC1=CC=C(C=C1C(F)(F)F)C2=CC(NC3=CC=C(C=C3)C4CCN(CC4)CC5CCN(CC5)C6=CC7=C(C(N(C7)C8CCC(NC8=O)=O)=O)C=C6)=NC=C2)N)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Guangrong Zheng, et al. WO2026011086A1. 2025.