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CHMP2A - charged multivesicular body protein 2A Gene

Also Known as BC2; BC-2; VPS2; CHMP2; VPS2A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27243

About CHMP2A

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:58,551,566-58,555,105 (from NCBI)

This gene has 11 transcripts (splice variants), 199 orthologues and 4 paralogues. Ubiquitous expression in colon (RPKM 34.2), kidney (RPKM 32.8) and 25 other tissues.

Summary

CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface Receptor Proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

CHMP2A Products (2)

mRNA	Protein	Name
NM_014453.4	NP_055268.1	charged multivesicular body protein 2a
NM_198426.3	NP_940818.1	charged multivesicular body protein 2a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylcholine binding	IMP IMP: Inferred from mutant phenotype	18687924	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14505570	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	17928862	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	23045692	GOA
involved in exit from mitosis	IMP IMP: Inferred from mutant phenotype	26040712	GOA
involved in late endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in membrane invagination	IMP IMP: Inferred from mutant phenotype	24878737	GOA
involved in midbody abscission	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	16554368	GOA
involved in negative regulation of centriole elongation	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in nuclear membrane reassembly	IMP IMP: Inferred from mutant phenotype	26040712	GOA
involved in nucleus organization	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in plasma membrane repair	IDA IDA: Inferred from direct assay	24482116	GOA
involved in positive regulation of exosomal secretion	IMP IMP: Inferred from mutant phenotype	22660413	GOA
involved in protein homooligomerization	IMP IMP: Inferred from mutant phenotype	18687924	GOA
involved in protein polymerization	IMP IMP: Inferred from mutant phenotype	23051622	GOA
involved in regulation of centrosome duplication	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	17984323	GOA
involved in viral budding from plasma membrane	IDA IDA: Inferred from direct assay	24878737	GOA
involved in viral budding from plasma membrane	IMP IMP: Inferred from mutant phenotype	14505570	GOA
involved in viral budding via host ESCRT complex	IDA IDA: Inferred from direct assay	24878737	GOA
involved in viral budding via host ESCRT complex	IGI IGI: Inferred from genetic interaction	24107264	GOA
involved in viral budding via host ESCRT complex	IMP IMP: Inferred from mutant phenotype	23051622	GOA
involved in viral release from host cell	IGI IGI: Inferred from genetic interaction	23051622	GOA
involved in viral release from host cell	IMP IMP: Inferred from mutant phenotype	23051622	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ESCRT III complex	IDA IDA: Inferred from direct assay	18687924	GOA
located in amphisome membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in chromatin	IDA IDA: Inferred from direct assay	28242692	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	26040712	GOA
located in kinetochore microtubule	IDA IDA: Inferred from direct assay	26040712	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	17984323	GOA
part of membrane coat	IMP IMP: Inferred from mutant phenotype	24878737	GOA
located in midbody	IDA IDA: Inferred from direct assay	26040712	GOA
located in multivesicular body membrane	IDA IDA: Inferred from direct assay	16554368	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	26040712	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	26040713	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24878737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHMP2A Protein Structure

Snf7

0
100
200
222 a.a.

Protein Preferred Names	Protein Names
charged multivesicular body protein 2a	VPS2 homolog A

CHMP2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CHMP2A	O43633	VPS4A	Homo sapiens	Q9UN37	Y2H	16730941
Intra	CHMP2A	O43633	CHMP3	Homo sapiens	Q9Y3E7	Y2H	16730941
Intra	CHMP2A	O43633	CHMP3	Homo sapiens	Q9Y3E7	SPR	23051622
Intra	CHMP2A	O43633	MITD1	Homo sapiens	Q8WV92	Confocal	16730941
Intra	CHMP2A	O43633	MITD1	Homo sapiens	Q8WV92	Y2H	16730941
Intra	CHMP2A	O43633	MITD1	Homo sapiens	Q8WV92	Y2H Prey Pooling	32296183
Intra	CHMP2A	O43633	MITD1	Homo sapiens	Q8WV92	Validated Y2H	32296183
Intra	CHMP2A	O43633	MITD1	Homo sapiens	Q8WV92	Beta Lactamase	16730941
Intra	CHMP2A	O43633	MITD1	Homo sapiens	Q8WV92	Y2H Array	32296183
Intra	CHMP2A	O43633	STAMBP	Homo sapiens	O95630	Y2H	16730941
Intra	CHMP2A	O43633	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	CHMP2A	O43633	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	CHMP2A	O43633	HTT	Homo sapiens	P42858	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7	Ftd3 Frontotemporal Dementia, Chromosome 3-Linked Amyotrophic Lateral Sclerosis, Chmp2b-Related Chromosome 3-Linked Frontotemporal Dementia FTDALS7 Chmp2b-Related Frontotemporal Dementia Amyotrophic Lateral Sclerosis 17, Formerly Als17, Formerly Amyotrophic Lateral Sclerosis Type 17 Dtm1 Ftd-3 Ftd-Chmp2b Als17 Amyotrophic Lateral Sclerosis 17 Sclerosis, Lateral, Amyotrophic, Type 17 Dementia, Frontotemporal, Chromosome 3-Linked
Hypertrichosis Universalis Congenita, Ambras Type	Ambras Syndrome Hypertrichosis, Congenital Generalized HTC1 HTC2 Chromosome Xq27.1 Interchromosomal Insertion Syndrome Cgh Hcg Ambras Type Hypertrichosis Universalis Congenita X-Linked Congenital Generalized Hypertrichosis Congenital Generalized Hypertrichosis, Macias-Flores Type Macias Flores-Garcia Cruz-Rivera Syndrome Htc 1 Hypertrichosis Universalis Congenita Ambras Type Hypertrichosis Congenital Generalized X-Linked Macias-Flores Garcia-Cruz Rivera Syndrome Congenital Generalized Hypertrichosis, Ambras Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02640	CHMP2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CHMP2A	MGD	MGI:1916203
Canis familiaris	CHMP2A	VGNC	VGNC:39222
Felis catus	CHMP2A	VGNC	VGNC:60862
Rattus norvegicus	CHMP2A	RGD	RGD:1305050
Bos taurus	CHMP2A	VGNC	VGNC:27300
Macaca mulatta	CHMP2A	VGNC	VGNC:71141