MITD1 - microtubule interacting and trafficking domain containing 1 Gene

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 129531

Summary

Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as a homodimer, with the N-termini binding to a subset of ESCRT-III subunits and the C-termini binding to membranes. The encoded protein regulates ESCRT-III activity and is required for proper cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

MITD1 Products (1)

mRNA Protein Name
NM_001320419.2 NP_001307348.1 MIT domain-containing protein 1 isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
23015756 GOA
enables phosphatidylinositol binding IMP
IMP: Inferred from mutant phenotype
23045692 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16730941 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
23015756 GOA
Biological Process GO Annotation Evidence References Source
involved in midbody abscission IMP
IMP: Inferred from mutant phenotype
23015756 GOA
involved in mitotic cytokinesis IMP
IMP: Inferred from mutant phenotype
23045692 GOA
NOT involved in multivesicular body sorting pathway IMP
IMP: Inferred from mutant phenotype
23015756 GOA
involved in negative regulation of protein binding IMP
IMP: Inferred from mutant phenotype
23015756 GOA
NOT involved in viral budding via host ESCRT complex IMP
IMP: Inferred from mutant phenotype
23045692 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
23045692 GOA
colocalizes with midbody IDA
IDA: Inferred from direct assay
23045692 GOA
located in midbody IMP
IMP: Inferred from mutant phenotype
23015756 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MIT domain-containing protein 1

  • MIT, microtubule interacting and transport, domain containing 1

MITD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MITD1 Q8WV92 ZFYVE19 Homo sapiens Q96K21-3
Y2H Prey Pooling
25416956
Intra
MITD1 Q8WV92 ZFYVE19 Homo sapiens Q96K21-3
Validated Y2H
25416956
Intra
MITD1 Q8WV92 CHMP1A Homo sapiens Q9HD42
Validated Y2H
32296183
Intra
MITD1 Q8WV92 GPHN Homo sapiens Q9NQX3-2
Validated Y2H
32296183
Intra
MITD1 Q8WV92 GPHN Homo sapiens Q9NQX3-2
Y2H Array
32296183
Intra
MITD1 Q8WV92 GPHN Homo sapiens Q9NQX3-2
Y2H Prey Pooling
32296183
Intra
MITD1 Q8WV92 RTN3 Homo sapiens O95197-3
Y2H Array
32296183
Intra
MITD1 Q8WV92 RTN3 Homo sapiens O95197-3
Y2H Prey Pooling
32296183
Intra
MITD1 Q8WV92 CHMP1B Homo sapiens Q7LBR1
Y2H Array
32296183
Intra
MITD1 Q8WV92 CHMP1B Homo sapiens Q7LBR1
Y2H Prey Pooling
32296183
Intra
MITD1 Q8WV92 TTC33 Homo sapiens Q6PID6
Y2H Prey Pooling
32296183
Intra
MITD1 Q8WV92 TTC33 Homo sapiens Q6PID6
Y2H Array
32296183
Intra
MITD1 Q8WV92 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra
MITD1 Q8WV92 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra
MITD1 Q8WV92 ZFYVE19 Homo sapiens Q96K21
Y2H Prey Pooling
32296183
Intra
MITD1 Q8WV92 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
Intra
MITD1 Q8WV92 ZFYVE19 Homo sapiens Q96K21
Validated Y2H
32296183
Intra
MITD1 Q8WV92 ZFYVE19 Homo sapiens Q96K21
Y2H Array
25416956
Intra
MITD1 Q8WV92 CHMP2A Homo sapiens O43633
Y2H
16730941
Intra
MITD1 Q8WV92 ZFYVE19 Homo sapiens Q96K21
Y2H Array
32296183
Intra
MITD1 Q8WV92 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
Intra
MITD1 Q8WV92 CARD10 Homo sapiens Q9BWT7
Validated Y2H
32296183
Intra
MITD1 Q8WV92 CHMP2A Homo sapiens O43633
Anti Tag CoIP
16730941
Intra
MITD1 Q8WV92 ZFYVE19 Homo sapiens Q96K21
Validated Y2H
25416956
Intra
MITD1 Q8WV92 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
MITD1 Q8WV92 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
MITD1 Q8WV92 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
MITD1 Q8WV92 CHMP5 Homo sapiens Q9NZZ3
Y2H Prey Pooling
25416956
Intra
MITD1 Q8WV92 CHMP5 Homo sapiens Q9NZZ3
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16423 MITD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21648 Mitd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28166 Mitd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown