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CHMP1B - charged multivesicular body protein 1B Gene

Also Known as Vps46B; C10orf2; C18orf2; CHMP1.5; Vps46-2; C18-ORF2; hVps46-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57132

About CHMP1B

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:11,851,413-11,854,444 (from NCBI)

This gene has 2 transcripts (splice variants), 189 orthologues and 4 paralogues.

Summary

CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface Receptor Proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

CHMP1B Products (1)

mRNA	Protein	Name
NM_020412.5	NP_065145.2	charged multivesicular body protein 1b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables MIT domain binding	IDA IDA: Inferred from direct assay	16174732	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16730941	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14505570	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	17928862	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in cell division	IMP IMP: Inferred from mutant phenotype	19129479	GOA
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	23015756	GOA
involved in late endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in midbody abscission	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	16554368	GOA
involved in nuclear membrane reassembly	IMP IMP: Inferred from mutant phenotype	26040713	GOA
involved in nucleus organization	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in plasma membrane repair	IDA IDA: Inferred from direct assay	24482116	GOA
involved in regulation of centrosome duplication	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	17984323	GOA
involved in viral budding from plasma membrane	IDA IDA: Inferred from direct assay	24878737	GOA
involved in viral budding via host ESCRT complex	IDA IDA: Inferred from direct assay	24878737	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ESCRT III complex	IDA IDA: Inferred from direct assay	24878737	GOA
located in amphisome membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	25556234	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	26040712	GOA
located in kinetochore microtubule	IDA IDA: Inferred from direct assay	26040712	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	17984323	GOA
part of membrane coat	IDA IDA: Inferred from direct assay	24878737	GOA
located in midbody	IDA IDA: Inferred from direct assay	26040712	GOA
located in multivesicular body membrane	IDA IDA: Inferred from direct assay	16554368	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	26040713	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24878737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHMP1B Protein Structure

Snf7

0
100
199 a.a.

Protein Preferred Names	Protein Names
charged multivesicular body protein 1b	chromatin modifying protein 1B

CHMP1B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CHMP1B	Q7LBR1	SNRNP200	Homo sapiens	O75643	Y2H	16730941
Intra	CHMP1B	Q7LBR1	USP8	Homo sapiens	P40818	Pull Down	17711858
Intra	CHMP1B	Q7LBR1	USP8	Homo sapiens	P40818	Anti Tag CoIP	17711858
Intra	CHMP1B	Q7LBR1	CHMP1A	Homo sapiens	Q9HD42	Anti Tag CoIP	33961781
Intra	CHMP1B	Q7LBR1	VPS4A	Homo sapiens	Q9UN37	SPR	17928862
Intra	CHMP1B	Q7LBR1	VPS4A	Homo sapiens	Q9UN37	Y2H	16730941
Intra	CHMP1B	Q7LBR1	IST1	Homo sapiens	P53990-4	SPR	19525971
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Y2H Array	25416956
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Y2H	16730941
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Y2H Array	32296183
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Beta Lactamase	16730941
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Y2H Prey Pooling	32296183
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Pull Down	17711858
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Anti Tag CoIP	16730941
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Y2H Array	31515488
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Anti Tag CoIP	17711858
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Y2H	17711858
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Confocal	16730941
Intra	CHMP1B	Q7LBR1	MITD1	Homo sapiens	Q8WV92	Validated Y2H	32296183
Intra	CHMP1B	Q7LBR1	VTA1	Homo sapiens	Q9NP79	Validated Y2H	32296183
Intra	CHMP1B	Q7LBR1	VTA1	Homo sapiens	Q9NP79	Y2H Array	32296183
Intra	CHMP1B	Q7LBR1	VTA1	Homo sapiens	Q9NP79	Y2H Prey Pooling	32296183
Intra	CHMP1B	Q7LBR1	VTA1	Homo sapiens	Q9NP79	Anti Tag CoIP	33961781
Intra	CHMP1B	Q7LBR1	RAB11A	Homo sapiens	P62491	Y2H	16730941
Intra	CHMP1B	Q7LBR1	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	CHMP1B	Q7LBR1	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	CHMP1B	Q7LBR1	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pontocerebellar Hypoplasia, Type 8	Pontocerebellar Hypoplasia Type 8 PCH8 Pontocerebellar Hypoplasia Due To Chmp1a Mutation Pontocerebellar Hypoplasia 8 Hypoplasia, Pontocerebellar, Type 8
Pontocerebellar Hypoplasia, Type 1a	Pontocerebellar Hypoplasia Type 1a PCH1A Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy Pontocerebellar Hypoplasia With Anterior Horn Cell Disease Pch1 Pontocerebellar Hypoplasia 1a Hypoplasia, Pontocerebellar, Type 1a Pontocerebellar Hypoplasia Type 1
Spastic Paraplegia 80, Autosomal Dominant	SPG80 Hereditary Spastic Paraplegia 80 Spastic Paraplegia 80 Autosomal Dominant Doid:0112341
Spinal Cord Neuroblastoma	Neuroblastoma Of The Spinal Cord
Spinal Cord Primitive Neuroectodermal Neoplasm	Spinal Cord Pnet Spinal Cord Primitive Neuroectodermal Tumor
Spastic Paraplegia 10, Autosomal Dominant	SPG10 Hereditary Spastic Paraplegia 10 Autosomal Dominant Spastic Paraplegia Type 10 Spastic Paraplegia 10 Spastic Paraplegia 10 With Or Without Peripheral Neuropathy Autosomal Dominant Spastic Paraplegia 10 Autosomal Dominant Spastic Paraplegia Spastic Paraplegia, Autosomal Dominant Paraplegia, Spastic, Autosomal Dominant, Type 10
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02639	CHMP1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CHMP1B	RGD	RGD:1593500
Mus musculus	CHMP1B	MGD	MGI:1914314