RAB11A - RAB11A, member RAS oncogene family Gene
Also Known as YL8
Species: Homo sapiens
About RAB11A
This gene has 9 transcripts (splice variants), 209 orthologues, 68 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 50.5), adrenal (RPKM 37.5) and 25 other tissues.
Summary
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
RAB11A Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001206836.2 | NP_001193765.1 | ras-related protein Rab-11A isoform 2 |
| NM_004663.5 | NP_004654.1 | ras-related protein Rab-11A isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables G protein activity |
IDA
IDA: Inferred from direct assay
|
15837192 | GOA |
| enables GTPase activity |
IDA
IDA: Inferred from direct assay
|
15837192 | GOA |
| enables dynein light intermediate chain binding |
IDA
IDA: Inferred from direct assay
|
20026645 | GOA |
| enables microtubule binding |
IDA
IDA: Inferred from direct assay
|
24561039 | GOA |
| enables myosin V binding |
IPI
IPI: Inferred from physical interaction
|
24006491 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12470645 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in Golgi membrane |
IDA
IDA: Inferred from direct assay
|
25673879 | GOA |
| colocalizes with centrosome |
IDA
IDA: Inferred from direct assay
|
24648492 | GOA |
| located in centrosome |
IDA
IDA: Inferred from direct assay
|
25849865 | GOA |
| located in cleavage furrow |
IDA
IDA: Inferred from direct assay
|
15601896 | GOA |
| located in cytoplasmic vesicle |
IDA
IDA: Inferred from direct assay
|
22613965 | GOA |
| located in endocytic vesicle membrane |
IDA
IDA: Inferred from direct assay
|
20026645 | GOA |
| located in extracellular exosome |
IDA
IDA: Inferred from direct assay
|
15326289 | GOA |
| is active in glutamatergic synapse |
IDA
IDA: Inferred from direct assay
|
26565907 | GOA |
| is active in glutamatergic synapse |
IMP
IMP: Inferred from mutant phenotype
|
26565907 | GOA |
| colocalizes with kinetochore microtubule |
IDA
IDA: Inferred from direct assay
|
24561039 | GOA |
| located in multivesicular body |
IDA
IDA: Inferred from direct assay
|
15634213 | GOA |
| located in phagocytic vesicle |
IDA
IDA: Inferred from direct assay
|
21255211 | GOA |
| is active in postsynaptic recycling endosome |
IDA
IDA: Inferred from direct assay
|
26565907 | GOA |
| is active in postsynaptic recycling endosome |
IMP
IMP: Inferred from mutant phenotype
|
26565907 | GOA |
| part of protein-containing complex |
IDA
IDA: Inferred from direct assay
|
17462998 | GOA |
| located in recycling endosome |
IDA
IDA: Inferred from direct assay
|
24561039 | GOA |
| located in spindle pole |
IDA
IDA: Inferred from direct assay
|
24561039 | GOA |
| located in trans-Golgi network |
IDA
IDA: Inferred from direct assay
|
15229288 | GOA |
| located in trans-Golgi network membrane |
IDA
IDA: Inferred from direct assay
|
25673879 | GOA |
| located in vesicle |
IDA
IDA: Inferred from direct assay
|
18570918 | GOA |
RAB11A Protein Structure
Ras: Ras family (13 - 173)
- 0
- 100
- 200
- 216 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
ras-related protein Rab-11A |
|
RAB11A Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
RAB11A | P62491 | RAB11FIP2 | Homo sapiens | Q7L804 | 33961781 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP2 | Homo sapiens | Q7L804 | 17082457 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP2 | Homo sapiens | Q7L804 | 28514442 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP2 | Homo sapiens | Q7L804 | 29997244 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP2 | Homo sapiens | Q7L804 | 32814053 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP2 | Homo sapiens | Q7L804 | 32296183 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP2 | Homo sapiens | Q7L804 | 26496610 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP2 | Homo sapiens | Q7L804 | 35271311 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP2 | Homo sapiens | Q7L804 | 29997244 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP5 | Homo sapiens | Q9BXF6 | 26496610 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP5 | Homo sapiens | Q9BXF6 | 33961781 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP5 | Homo sapiens | Q9BXF6 | 29568061 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP5 | Homo sapiens | Q9BXF6 | 28514442 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP5 | Homo sapiens | Q9BXF6 | 35271311 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP5 | Homo sapiens | Q9BXF6 | 24591568 | |
|
Intra
|
RAB11A | P62491 | MYO5B | Homo sapiens | Q9ULV0-2 | 32296183 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP3 | Homo sapiens | O75154-1 | 17030804 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP3 | Homo sapiens | O75154-1 | 26258637 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP3 | Homo sapiens | O75154-1 | 24876499 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP3 | Homo sapiens | O75154-1 | 17030804 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP3 | Homo sapiens | O75154-1 | 26258637 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP3 | Homo sapiens | O75154-1 | 17030804 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP3 | Homo sapiens | O75154-1 | 17030804 | |
|
Intra
|
RAB11A | P62491 | RAB11FIP4 | Homo sapiens | Q86YS3-1 | 17030804 | |
|
Intra
|
RAB11A | P62491 | CHMP1B | Homo sapiens | Q7LBR1 | 16730941 | |
|
Intra
|
RAB11A | P62491 | KLF15 | Homo sapiens | Q9UIH9 | 32814053 | |
|
Intra
|
RAB11A | P62491 | KLF15 | Homo sapiens | Q9UIH9 | 32814053 | |
|
Intra
|
RAB11A | P62491 | KLF15 | Homo sapiens | Q9UIH9 | 32814053 | |
|
Intra
|
RAB11A | P62491 | ZFYVE27 | Homo sapiens | Q5T4F4 | 17082457 | |
|
Intra
|
RAB11A | P62491 | ZFYVE27 | Homo sapiens | Q5T4F4 | 17082457 | |
|
Intra
|
RAB11A | P62491 | ITGB3BP | Homo sapiens | Q13352 | 32814053 | |
|
Intra
|
RAB11A | P62491 | ITGB3BP | Homo sapiens | Q13352 | 32814053 | |
|
Intra
|
RAB11A | P62491 | ITGB3BP | Homo sapiens | Q13352 | 32814053 | |
|
Intra
|
RAB11A | P62491 | RAB3IP | Homo sapiens | Q96QF0-2 | 26258637 | |
|
Intra
|
RAB11A | P62491 | RAB3IP | Homo sapiens | Q96QF0-2 | 20308558 | |
|
Intra
|
RAB11A | P62491 | RAB3IP | Homo sapiens | Q96QF0-2 | 26258637 | |
|
Intra
|
RAB11A | P62491 | RAB3IP | Homo sapiens | Q96QF0-2 | 26258637 | |
|
Intra
|
RAB11A | P62491 | ZNF232 | Homo sapiens | Q9UNY5 | 32814053 | |
|
Intra
|
RAB11A | P62491 | ZNF232 | Homo sapiens | Q9UNY5 | 32814053 | |
|
Intra
|
RAB11A | P62491 | ZNF232 | Homo sapiens | Q9UNY5 | 32814053 | |
|
Intra
|
RAB11A | P62491 | EVI5 | Homo sapiens | O60447 | 26496610 | |
|
Intra
|
RAB11A | P62491 | EVI5 | Homo sapiens | O60447 | 35271311 |
RAB11A Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P810819 | RAB11A Antibody (YA10062) | WB, IHC-P | Human, Mouse, Rat |
| HY-P83231 | Rab11A Antibody (YA2976) | WB, IP | Human, Mouse, Rat |
| HY-P86102 | RB11 Antibody (YA5794) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Autosomal Dominant Non-Syndromic Intellectual Disability |
|
|
| Arthrogryposis, Renal Dysfunction, And Cholestasis 1 |
|
|
| Microvillus Inclusion Disease |
|
|
| Charcot-Marie-Tooth Disease, Type 4c |
|
|
| Congenital Diarrhea |
|
|
| Carpenter Syndrome 1 |
|
|
| Charcot-Marie-Tooth Disease |
|
|
| Charcot-Marie-Tooth Disease, Axonal, Type 2b |
|
|
| Pontocerebellar Hypoplasia, Type 2e |
|
|
| Griscelli Syndrome |
|
|
| Charcot-Marie-Tooth Disease, Axonal, Type 2e |
|
|
| Warburg Micro Syndrome 1 |
|
|
| Cystic Fibrosis |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Hermansky-Pudlak Syndrome |
|
|
| Joubert Syndrome 1 |
|
|
| Hereditary Spastic Paraplegia |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Cone-Rod Dystrophy 2 |
|
|
| Retinitis Pigmentosa |
|
|
| Congenital Nervous System Abnormality |
|
|
| Fundus Dystrophy |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | RAB11A | MGD | MGI:1858202 |
| Canis familiaris | RAB11A | VGNC | VGNC:45248 |
| Rattus norvegicus | RAB11A | RGD | RGD:619762 |
| Macaca mulatta | RAB11A | VGNC | VGNC:81517 |
| Felis catus | RAB11A | VGNC | VGNC:97579 |
| Bos taurus | RAB11A | VGNC | VGNC:33614 |
| Others | RAB11A | NCBI |