RAB11FIP5 - RAB11 family interacting protein 5 Gene

Also Known as GAF1; pp75; RIP11; gaf-1; rab11-FIP5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26056

About RAB11FIP5

Cytogenetic location: 2p13.2 Genomic coordinates (GRCh38): 2:73,073,382-73,112,948 (from NCBI)

This gene has 6 transcripts (splice variants), 285 orthologues and 2 paralogues. Broad expression in testis (RPKM 48.5), kidney (RPKM 16.7) and 18 other tissues.

Summary

Enables gamma-tubulin binding activity. Involved in cellular response to acidic pH; negative regulation of Adiponectin secretion; and regulation of protein localization to cell surface. Located in centriolar satellite and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]

RAB11FIP5 Products (2)

mRNA	Protein	Name
NM_001371272.1	NP_001358201.1	rab11 family-interacting protein 5 isoform 1
NM_015470.3	NP_056285.1	rab11 family-interacting protein 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables gamma-tubulin binding	IDA IDA: Inferred from direct assay	11278501	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11278501	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to acidic pH	IDA IDA: Inferred from direct assay	20717956	GOA
involved in negative regulation of adiponectin secretion	IDA IDA: Inferred from direct assay	24040321	GOA
involved in regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	20717956	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	11278501	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB11FIP5 Protein Structure

C2

RBD-FIP

0
100
200
300
400
500
600
653 a.a.

Protein Preferred Names	Protein Names
rab11 family-interacting protein 5	RAB11 family interacting protein 5 (class I)

RAB11FIP5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAB11FIP5	Q9BXF6	KIF3A	Homo sapiens	Q9Y496	Pull Down	24591568
Intra	RAB11FIP5	Q9BXF6	SNX18	Homo sapiens	Q96RF0	Pull Down	24591568
Intra	RAB11FIP5	Q9BXF6	RAB11A	Homo sapiens	P62491	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neonatal Lupus Erythematosus	Neonatal Systemic Lupus Erythematosus
Mucocutaneous Leishmaniasis	American Cutaneous Leishmaniasis American Mucocutaneous Leishmaniasis Cutaneous Leishmaniasis, American Mucocutaneous Leishmaniasis, American New World Cutaneous Leishmaniasis Leishmaniasis, Mucocutaneous Espundia Leishmania Braziliensis Infection
Splenic Disease	Splenic Diseases Dyssplenism Spleen Disease Abnormality Of The Spleen Spleen Diseases
Visceral Leishmaniasis	Kala-Azar Leishmaniasis, Visceral Infection By Visceral Leishmaniasis Leishmaniasis Visceral Sahib Disease Ponos Burdwan Fever Mard El Bicha Sirkari Disease Indian Visceral Leishmaniasis Dumdum Fever Visceral Leishmaniasis Due To Leishmania Donovani

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11520	RAB11FIP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RAB11FIP5	VGNC	VGNC:64471
Bos taurus	RAB11FIP5	VGNC	VGNC:54474
Canis familiaris	RAB11FIP5	VGNC	VGNC:45252
Mus musculus	RAB11FIP5	MGD	MGI:1098586
Rattus norvegicus	RAB11FIP5	RGD	RGD:1592069
Macaca mulatta	RAB11FIP5	VGNC	VGNC:106203
Others	RAB11FIP5	NCBI