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SNX18 - sorting nexin 18 Gene

Also Known as SNAG1; SH3PX2; SH3PXD3B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 112574

About SNX18

This gene has 3 transcripts (splice variants), 271 orthologues and 15 paralogues. Ubiquitous expression in bone marrow (RPKM 13.6), ovary (RPKM 10.4) and 25 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SNX18 Products (3)

mRNA	Protein	Name
NM_001102575.2	NP_001096045.1	sorting nexin-18 isoform a
NM_001145427.2	NP_001138899.1	sorting nexin-18 isoform c
NM_052870.4	NP_443102.2	sorting nexin-18 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	23878278	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20427313	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cleavage furrow formation	IMP IMP: Inferred from mutant phenotype	22718350	GOA
involved in endocytosis	IDA IDA: Inferred from direct assay	20427313	GOA
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	22718350	GOA
involved in endosomal transport	IMP IMP: Inferred from mutant phenotype	22718350	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	22718350	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	20427313	GOA
involved in positive regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	29437695	GOA
involved in protein transport	IMP IMP: Inferred from mutant phenotype	29437695	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with clathrin-coated vesicle	IDA IDA: Inferred from direct assay	20427313	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	20427313	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	22718350	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	15326289	GOA
is active in recycling endosome membrane	IMP IMP: Inferred from mutant phenotype	29437695	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX18 Protein Structure

SH3_9

BAR_3_WASP_bdg

0
100
200
300
400
500
628 a.a.

Protein Preferred Names	Protein Names
sorting nexin-18	SH3 and PX domain-containing protein 3B

SNX18 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNX18	Q96RF0	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	SNX18	Q96RF0	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	SNX18	Q96RF0	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	SNX18	Q96RF0	CPSF7	Homo sapiens	Q8N684-3	Y2H Prey Pooling	32296183
Intra	SNX18	Q96RF0	CPSF7	Homo sapiens	Q8N684-3	Y2H Array	32296183
Intra	SNX18	Q96RF0	MSS51	Homo sapiens	Q4VC12	Y2H Array	32296183
Intra	SNX18	Q96RF0	MSS51	Homo sapiens	Q4VC12	Y2H Prey Pooling	32296183
Intra	SNX18	Q96RF0	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	SNX18	Q96RF0	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	SNX18	Q96RF0	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
Intra	SNX18	Q96RF0	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
Intra	SNX18	Q96RF0	RAB11FIP5	Homo sapiens	Q9BXF6	Pull Down	24591568
Intra	SNX18	Q96RF0	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	SNX18	Q96RF0	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	SNX18	Q96RF0	PTPN21	Homo sapiens	Q16825	Y2H Prey Pooling	32296183
Intra	SNX18	Q96RF0	PTPN21	Homo sapiens	Q16825	Y2H Array	32296183
Intra	SNX18	Q96RF0	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	SNX18	Q96RF0	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	SNX18	Q96RF0	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	SNX18	Q96RF0	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	SNX18	Q96RF0	DPPA4	Homo sapiens	Q7L190	Validated Y2H	32296183
Intra	SNX18	Q96RF0	DPPA4	Homo sapiens	Q7L190	Y2H Array	32296183
Intra	SNX18	Q96RF0	DPPA4	Homo sapiens	Q7L190	Y2H Prey Pooling	32296183
Intra	SNX18	Q96RF0	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	SNX18	Q96RF0	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	SNX18	Q96RF0	KHDRBS3	Homo sapiens	O75525	Y2H Array	32296183
Intra	SNX18	Q96RF0	KHDRBS3	Homo sapiens	O75525	Y2H Prey Pooling	32296183
Intra	SNX18	Q96RF0	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	SNX18	Q96RF0	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	SNX18	Q96RF0	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	SNX18	Q96RF0	HSPB2	Homo sapiens	Q16082	Y2H Prey Pooling	32296183
Intra	SNX18	Q96RF0	HSPB2	Homo sapiens	Q16082	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13531	SNX18 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SNX18	MGD	MGI:2137642
Canis familiaris	SNX18	VGNC	VGNC:46627
Macaca mulatta	SNX18	VGNC	VGNC:77738
Felis catus	SNX18	VGNC	VGNC:65548
Rattus norvegicus	SNX18	RGD	RGD:1310367
Bos taurus	SNX18	VGNC	VGNC:35098
Others	SNX18	NCBI