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KHDRBS3 - KH RNA binding domain containing, signal transduction associated 3 Gene

Also Known as Etle; SALP; SLM2; SLM-2; TSTAR; T-STAR; etoile

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10656

About KHDRBS3

Cytogenetic location: 8q24.23 Genomic coordinates (GRCh38): 8:135,457,456-135,656,516 (from NCBI)

This gene has 13 transcripts (splice variants), 217 orthologues and 4 paralogues. Biased expression in testis (RPKM 33.1), brain (RPKM 14.0) and 10 other tissues.

Summary

Enables RNA binding activity; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome and spermatogenesis. Located in nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

KHDRBS3 Products (1)

mRNA	Protein	Name
NM_006558.3	NP_006549.1	KH domain-containing, RNA-binding, signal transduction-associated protein 3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	19561594	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	10332027	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10332027	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	10332027	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IMP IMP: Inferred from mutant phenotype	10332027	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	10332027	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
KH domain-containing, RNA-binding, signal transduction-associated protein 3	KH domain containing, RNA binding, signal transduction associated 3

KHDRBS3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KHDRBS3	O75525	TSGA10IP	Homo sapiens	Q3SY00	Validated Y2H	32296183
Intra	KHDRBS3	O75525	MARK4	Homo sapiens	Q6IPE9	Validated Y2H	25416956
Intra	KHDRBS3	O75525	MARK4	Homo sapiens	Q6IPE9	Y2H Array	25416956
Intra	KHDRBS3	O75525	MARK4	Homo sapiens	Q6IPE9	Y2H Prey Pooling	25416956
Intra	KHDRBS3	O75525	PCDHB14	Homo sapiens	Q9Y5E9	Validated Y2H	32296183
Intra	KHDRBS3	O75525	RFC3	Homo sapiens	P40938	Validated Y2H	32296183
Intra	KHDRBS3	O75525	LMNTD2	Homo sapiens	Q8IXW0	Validated Y2H	32296183
Intra	KHDRBS3	O75525	KHDRBS1	Homo sapiens	Q07666	Y2H	22365833
Intra	KHDRBS3	O75525	INPP5D	Homo sapiens	Q92835	Validated Y2H	25416956
Intra	KHDRBS3	O75525	TYK2	Homo sapiens	P29597	Validated Y2H	32296183
Intra	KHDRBS3	O75525	ZNF575	Homo sapiens	Q86XF7	Validated Y2H	32296183
Intra	KHDRBS3	O75525	MGC50722	Homo sapiens	Q8IVT4	Validated Y2H	32296183
Intra	KHDRBS3	O75525	PRPF31	Homo sapiens	Q8WWY3	Y2H Prey Pooling	25416956
Intra	KHDRBS3	O75525	PRPF31	Homo sapiens	Q8WWY3	Y2H Array	25416956
Intra	KHDRBS3	O75525	PRPF31	Homo sapiens	Q8WWY3	Validated Y2H	25416956
Intra	KHDRBS3	O75525	SHANK3	Homo sapiens	Q9BYB0	Anti Tag CoIP	21653829
Intra	KHDRBS3	O75525	SHANK3	Homo sapiens	Q9BYB0	Y2H Pooling	21653829
Intra	KHDRBS3	O75525	ZNF326	Homo sapiens	Q5BKZ1	Validated Y2H	32296183
Intra	KHDRBS3	O75525	PRR3	Homo sapiens	P79522	Validated Y2H	32296183
Intra	KHDRBS3	O75525	YTHDC1	Homo sapiens	Q96MU7	Validated Y2H	32296183
Intra	KHDRBS3	O75525	YTHDC1	Homo sapiens	Q96MU7	Validated Y2H	25416956
Intra	KHDRBS3	O75525	YTHDC1	Homo sapiens	Q96MU7	Y2H Prey Pooling	25416956
Intra	KHDRBS3	O75525	YTHDC1	Homo sapiens	Q96MU7	Y2H Array	25416956
Intra	KHDRBS3	O75525	RPH3AL	Homo sapiens	Q9UNE2	Validated Y2H	32296183
Intra	KHDRBS3	O75525	MYPOP	Homo sapiens	Q86VE0	Validated Y2H	32296183
Intra	KHDRBS3	O75525	RBM3	Homo sapiens	P98179	Validated Y2H	32296183
Intra	KHDRBS3	O75525	SNX18	Homo sapiens	Q96RF0	Validated Y2H	32296183
Intra	KHDRBS3	O75525	RASAL3	Homo sapiens	Q86YV0	Validated Y2H	32296183
Intra	KHDRBS3	O75525	ZNF408	Homo sapiens	Q9H9D4	Validated Y2H	32296183
Intra	KHDRBS3	O75525	ZNF408	Homo sapiens	Q9H9D4	Y2H Pooling	16189514
Intra	KHDRBS3	O75525	NELFB	Homo sapiens	Q8WX92	TAP	20195357
Intra	KHDRBS3	O75525	NELFB	Homo sapiens	Q8WX92	Display Tech	20195357
Intra	KHDRBS3	O75525	PSMA1	Homo sapiens	P25786	Validated Y2H	32296183
Intra	KHDRBS3	O75525	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	32296183
Intra	KHDRBS3	O75525	DOCK2	Homo sapiens	Q92608	Validated Y2H	32296183
Intra	KHDRBS3	O75525	HNRNPK	Homo sapiens	P61978-2	Validated Y2H	32296183
Intra	KHDRBS3	O75525	HBZ	Homo sapiens	P02008	Validated Y2H	32296183
Intra	KHDRBS3	O75525	RASD1	Homo sapiens	Q9Y272	Validated Y2H	32296183
Intra	KHDRBS3	O75525	CNNM3	Homo sapiens	Q8NE01	Validated Y2H	32296183
Intra	KHDRBS3	O75525	BAHD1	Homo sapiens	Q8TBE0	Y2H Prey Pooling	25416956
Intra	KHDRBS3	O75525	BAHD1	Homo sapiens	Q8TBE0	Y2H Pooling	16189514
Intra	KHDRBS3	O75525	BAHD1	Homo sapiens	Q8TBE0	Validated Y2H	25416956
Intra	KHDRBS3	O75525	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Pooling	16189514
Intra	KHDRBS3	O75525	KHDRBS2	Homo sapiens	Q5VWX1	Validated Y2H	32296183
Intra	KHDRBS3	O75525	RBMX	Homo sapiens	P38159	Y2H Pooling	16189514
Intra	KHDRBS3	O75525	RBMX	Homo sapiens	P38159	Validated Y2H	32296183
Intra	KHDRBS3	O75525	AQP1	Homo sapiens	P29972	Validated Y2H	32296183
Intra	KHDRBS3	O75525	ZNF580	Homo sapiens	Q9UK33	Validated Y2H	32296183
Intra	KHDRBS3	O75525	INPP5D	Homo sapiens	Q92835-2	Validated Y2H	32296183
Intra	KHDRBS3	O75525	DMRT3	Homo sapiens	Q9NQL9	Y2H Prey Pooling	25416956
Intra	KHDRBS3	O75525	DMRT3	Homo sapiens	Q9NQL9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hypophosphatasia, Adult	Adult Hypophosphatasia Odontohypophosphatasia Hypophosphatasia, Mild HPPA Hypophosphatasia Mild Hypophosphatasia Adult Rathbun Disease Adult Phosphoethanolaminuria HOPS
Localized Osteosarcoma	Localised Osteogenic Sarcoma Localised Osteosarcoma Localized Osteogenic Sarcoma
Tick Infestation	Tick Infestations
Hypophosphatasia	Phosphoethanolaminuria Childhood Hypophosphatasia Deficiency Of Alkaline Phosphatase Hypophospatasia, Childhood Hypophosphatasia Mild Phosphoethanol-Aminuria Rathburn Disease Hpp Rathbun Disease Hypophosphatasia, Childhood Infantile Hypophosphatasia
Osteopetrosis	Marble Bone Disease Albers-Schonberg Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07239	KHDRBS3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KHDRBS3	VGNC	VGNC:63079
Canis familiaris	KHDRBS3	VGNC	VGNC:42337
Macaca mulatta	KHDRBS3	VGNC	VGNC:73849
Rattus norvegicus	KHDRBS3	RGD	RGD:620921
Bos taurus	KHDRBS3	VGNC	VGNC:30542
Mus musculus	KHDRBS3	MGD	MGI:1313312
Others	KHDRBS3	NCBI