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RASD1 - ras related dexamethasone induced 1 Gene

Also Known as AGS1; DEXRAS1; MGC:26290

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51655

About RASD1

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:17,494,437-17,496,395 (from NCBI)

This gene has 2 transcripts (splice variants), 123 orthologues and 35 paralogues. Broad expression in fat (RPKM 57.3), kidney (RPKM 34.9) and 16 other tissues.

Summary

This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]

RASD1 Products (2)

mRNA	Protein	Name
NM_001199989.2	NP_001186918.1	dexamethasone-induced Ras-related protein 1 isoform 2
NM_016084.5	NP_057168.1	dexamethasone-induced Ras-related protein 1 isoform 1 proprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASD1 Protein Structure

Ras

0
100
200
281 a.a.

Protein Preferred Names	Protein Names
dexamethasone-induced Ras-related protein 1	RAS, dexamethasone-induced 1

RASD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RASD1	Q9Y272	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	RASD1	Q9Y272	KRTAP10-9	Homo sapiens	P60411	Y2H Array	32296183
Intra	RASD1	Q9Y272	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	RASD1	Q9Y272	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Array	32296183
Intra	RASD1	Q9Y272	CDR2L	Homo sapiens	Q86X02	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	RASD1	Q9Y272	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	RASD1	Q9Y272	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	RASD1	Q9Y272	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	RASD1	Q9Y272	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Array	32296183
Intra	RASD1	Q9Y272	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	HNRNPR	Homo sapiens	O43390-2	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	HNRNPR	Homo sapiens	O43390-2	Y2H Array	32296183
Intra	RASD1	Q9Y272	PRDM5	Homo sapiens	Q9NQX1-2	Y2H Array	32296183
Intra	RASD1	Q9Y272	PRDM5	Homo sapiens	Q9NQX1-2	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	RASD1	Q9Y272	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	RASD1	Q9Y272	MKRN3	Homo sapiens	Q13064	Y2H Array	32296183
Intra	RASD1	Q9Y272	MKRN3	Homo sapiens	Q13064	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	PTPN21	Homo sapiens	Q16825	Y2H Array	32296183
Intra	RASD1	Q9Y272	PTPN21	Homo sapiens	Q16825	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	HNRNPK	Homo sapiens	P61978	Y2H Prey Pooling	25416956
Intra	RASD1	Q9Y272	HNRNPK	Homo sapiens	P61978	Validated Y2H	25416956
Intra	RASD1	Q9Y272	RASAL3	Homo sapiens	Q86YV0	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	RASAL3	Homo sapiens	Q86YV0	Y2H Array	32296183
Intra	RASD1	Q9Y272	MATR3	Homo sapiens	P43243	Y2H Prey Pooling	25416956
Intra	RASD1	Q9Y272	MATR3	Homo sapiens	P43243	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	MATR3	Homo sapiens	P43243	Y2H Array	32296183
Intra	RASD1	Q9Y272	EXOSC8	Homo sapiens	Q96B26	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	EXOSC8	Homo sapiens	Q96B26	Y2H Array	32296183
Intra	RASD1	Q9Y272	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	RASD1	Q9Y272	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	KRTAP26-1	Homo sapiens	Q6PEX3	Y2H Array	32296183
Intra	RASD1	Q9Y272	KRTAP26-1	Homo sapiens	Q6PEX3	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	RASD1	Q9Y272	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
Intra	RASD1	Q9Y272	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	KHDRBS3	Homo sapiens	O75525	Y2H Array	32296183
Intra	RASD1	Q9Y272	KHDRBS3	Homo sapiens	O75525	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	RASD1	Q9Y272	WWP2	Homo sapiens	O00308	Y2H Array	32296183
Intra	RASD1	Q9Y272	WWP2	Homo sapiens	O00308	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	32296183
Intra	RASD1	Q9Y272	RBMY1F	Homo sapiens	Q15415	Y2H Array	25416956
Intra	RASD1	Q9Y272	RBMY1F	Homo sapiens	Q15415	Y2H Array	32296183
Intra	RASD1	Q9Y272	RBMY1F	Homo sapiens	Q15415	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Malt Worker'S Lung	Alveolitis Due To Aspergillus Clavatus Malt Worker Lung Malt Workers' Lung Malt-Workers' Lung Malt Fever Malt House Workers' Cough Malt-Workers' Alveolitis Malt-Workers' Lung Disease Alveolitis Due To Aspergillus Fumigatus Extrinsic Allergic Alveolitis Due To Aspergillus Spp
Potocki-Lupski Syndrome	PTLS Chromosome 17p11.2 Duplication Syndrome 17p11.2 Microduplication Syndrome Duplication 17p11.2 Syndrome Trisomy 17p11.2 Potocki-Lupski Syndrome (Dup(17)(P11.2p11.2)) 17p11.2 Duplication Syndrome Dup(17)(P11.2p11.2) Pls Chromosome 17, Trisomy 17p11 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11685	RASD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21721	Rasd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28239	Rasd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RASD1	VGNC	VGNC:45364
Bos taurus	RASD1	VGNC	VGNC:33740
Mus musculus	RASD1	MGD	MGI:1270848
Rattus norvegicus	RASD1	RGD	RGD:619727
Felis catus	RASD1	VGNC	VGNC:64498
Macaca mulatta	RASD1	VGNC	VGNC:76485
Others	RASD1	NCBI