RASAL3 - RAS protein activator like 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64926

About RASAL3

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,451,624-15,464,544 (from NCBI)

This gene has 7 transcripts (splice variants), 198 orthologues and 10 paralogues. Broad expression in lymph node (RPKM 18.0), spleen (RPKM 15.7) and 14 other tissues.

Summary

This gene belongs to the Ras GTPase-activating proteins (RasGAP) family and encodes a protein with pleckstrin homology (PH), C2, and Ras GTPase-activation protein (RasGAP) domains. This protein is localized near or at the plasma membrane when expressed exogenously. Reduced expression of this gene in some cell lines resulted in increased levels of the active form of Ras (Ras-GTP), suggesting that this gene may play a role in negatively regulating the Ras signaling pathway. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

RASAL3 Products (8)

mRNA Protein Name
NM_001348027.2 NP_001334956.1 RAS protein activator like-3 isoform 2
NM_001348028.2 NP_001334957.1 RAS protein activator like-3 isoform 3
NM_001400377.1 NP_001387306.1 RAS protein activator like-3 isoform 4
NM_001400378.1 NP_001387307.1 RAS protein activator like-3 isoform 5
NM_001400379.1 NP_001387308.1 RAS protein activator like-3 isoform 6
NM_001400380.1 NP_001387309.1 RAS protein activator like-3 isoform 7
NM_001400381.1 NP_001387310.1 RAS protein activator like-3 isoform 8
NM_022904.3 NP_075055.1 RAS protein activator like-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
25652366 GOA
involved in positive regulation of NK T cell proliferation IMP
IMP: Inferred from mutant phenotype
25652366 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25652366 GOA
located in cytoplasmic side of membrane IDA
IDA: Inferred from direct assay
25652366 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASAL3 Protein Structure

RasGAP

RasGAP: GTPase-activator protein for Ras-like GTPase (480 - 650)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1011 a.a.
Protein Preferred Names Protein Names

RAS protein activator like-3

RASAL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RASAL3 Q86YV0 CCDC102B Homo sapiens Q68D86
Y2H Array
32296183
Intra
RASAL3 Q86YV0 CCDC102B Homo sapiens Q68D86
Y2H Prey Pooling
32296183
Intra
RASAL3 Q86YV0 PPP1R13B Homo sapiens Q96KQ4
Validated Y2H
32296183
Intra
RASAL3 Q86YV0 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
Intra
RASAL3 Q86YV0 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
Intra
RASAL3 Q86YV0 CDR2L Homo sapiens Q86X02
Y2H Prey Pooling
32296183
Intra
RASAL3 Q86YV0 CDR2L Homo sapiens Q86X02
Y2H Array
32296183
Intra
RASAL3 Q86YV0 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
RASAL3 Q86YV0 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
RASAL3 Q86YV0 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
RASAL3 Q86YV0 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
RASAL3 Q86YV0 WASF3 Homo sapiens Q9UPY6-2
Y2H Array
32296183
Intra
RASAL3 Q86YV0 WASF3 Homo sapiens Q9UPY6-2
Y2H Prey Pooling
32296183
Intra
RASAL3 Q86YV0 WASF3 Homo sapiens Q9UPY6-2
Validated Y2H
32296183
Intra
RASAL3 Q86YV0 RABGEF1 Homo sapiens Q9UJ41-4
Validated Y2H
32296183
Intra
RASAL3 Q86YV0 RABGEF1 Homo sapiens Q9UJ41-4
Y2H Array
32296183
Intra
RASAL3 Q86YV0 RABGEF1 Homo sapiens Q9UJ41-4
Y2H Prey Pooling
32296183
Intra
RASAL3 Q86YV0 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
RASAL3 Q86YV0 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
RASAL3 Q86YV0 BEGAIN Homo sapiens Q9BUH8
Y2H Array
32296183
Intra
RASAL3 Q86YV0 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
Intra
RASAL3 Q86YV0 ccsb orf id: 52859 Homo sapiens EBI-16435328
Y2H Array
32296183
Intra
RASAL3 Q86YV0 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
Intra
RASAL3 Q86YV0 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
Intra
RASAL3 Q86YV0 ccsb orf id: 52859 Homo sapiens EBI-16435328
Y2H Prey Pooling
32296183
Intra
RASAL3 Q86YV0 BEGAIN Homo sapiens Q9BUH8
Y2H Prey Pooling
32296183
Intra
RASAL3 Q86YV0 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
RASAL3 Q86YV0 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
RASAL3 Q86YV0 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
RASAL3 Q86YV0 HNRNPK Homo sapiens P61978-2
Validated Y2H
32296183
Intra
RASAL3 Q86YV0 KHDRBS3 Homo sapiens O75525
Y2H Array
32296183
Intra
RASAL3 Q86YV0 KHDRBS3 Homo sapiens O75525
Y2H Prey Pooling
32296183
Intra
RASAL3 Q86YV0 RASD1 Homo sapiens Q9Y272
Validated Y2H
32296183
Intra
RASAL3 Q86YV0 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
RASAL3 Q86YV0 BEGAIN Homo sapiens Q9BUH8
Validated Y2H
32296183
Intra
RASAL3 Q86YV0 DEF6 Homo sapiens Q9H4E7
Validated Y2H
32296183
Intra
RASAL3 Q86YV0 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
RASAL3 Q86YV0 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
RASAL3 Q86YV0 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mycoplasma Pneumoniae Pneumonia

  • Mycoplasmal Pneumonia

  • Mycoplasma Pneumonia

  • Pneumonia Due To Mycoplasma Pneumoniae

  • Cold Agglutinin Positive Pneumonia

  • Pneumonia Due To Eaton'S Agent

  • Pneumonia, Mycoplasma

  • Eaton Agent Pneumonia

  • Endemic Pneumonia

  • Primary Atypical Pneumonia Due To Mycoplasma Pneumoniae

  • Infection By Pplo - [Pleuro-Pneumonia-Like-Organism]

  • Pneumonia Due To Pplo - [Pleuro-Pneumonia-Like-Organism]

  • Pleuro-Pneumonia-Like-Organism

  • Mycoplasma Infection With Eaton'S Agent
Epiphyseal Dysplasia, Multiple, 1

  • EDM1

  • Multiple Epiphyseal Dysplasia 1

  • Multiple Epiphyseal Dysplasia Type 1

  • Med1

  • Multiple Epiphyseal Dysplasia Comp-Related

  • Polyepiphyseal Dysplasia Type 1

  • Multiple Epiphyseal Dysplasia, Comp-Related

  • Epiphyseal Dysplasia Multiple 1

  • Epiphyseal Dysplasia, Multiple 1

  • Dysplasia, Epiphyseal, Multiple, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11684 RASAL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RASAL3 VGNC VGNC:76543
Rattus norvegicus RASAL3 RGD RGD:1309019
Canis familiaris RASAL3 VGNC VGNC:45363
Mus musculus RASAL3 MGD MGI:2444128
Bos taurus RASAL3 VGNC VGNC:33739
Felis catus RASAL3 VGNC VGNC:64497
Others RASAL3 NCBI