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PPP1R13B - protein phosphatase 1 regulatory subunit 13B Gene

Also Known as p85; ASPP1; p53BP2-like

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23368

About PPP1R13B

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,733,195-103,848,814 (from NCBI)

This gene has 18 transcripts (splice variants), 282 orthologues and 1 paralogue. Broad expression in thyroid (RPKM 17.5), testis (RPKM 15.0) and 24 other tissues.

Summary

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of Apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]

PPP1R13B Products (1)

mRNA	Protein	Name
NM_015316.3	NP_056131.2	apoptosis-stimulating of p53 protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11684014	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IDA IDA: Inferred from direct assay	11684014	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	11684014	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R13B Protein Structure

Ank_2

SH3_1

0
200
400
600
800
1000
1090 a.a.

Protein Preferred Names	Protein Names
apoptosis-stimulating of p53 protein 1	apoptosis-stimulating protein of p53, 1

PPP1R13B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPP1R13B	Q96KQ4	CCDC184	Homo sapiens	Q52MB2	Validated Y2H	25416956
Intra	PPP1R13B	Q96KQ4	CCDC184	Homo sapiens	Q52MB2	Y2H Array	25416956
Intra	PPP1R13B	Q96KQ4	HNRNPUL1	Homo sapiens	Q9BUJ2	Validated Y2H	32296183
Intra	PPP1R13B	Q96KQ4	RASSF8	Homo sapiens	Q8NHQ8-2	MAPPIT	32296183
Intra	PPP1R13B	Q96KQ4	MIS18A	Homo sapiens	Q9NYP9	Validated Y2H	32296183
Intra	PPP1R13B	Q96KQ4	SALL1	Homo sapiens	Q9NSC2	Validated Y2H	32296183
Intra	PPP1R13B	Q96KQ4	TEX12	Homo sapiens	Q9BXU0	Validated Y2H	32296183
Intra	PPP1R13B	Q96KQ4	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	PPP1R13B	Q96KQ4	CAPN7	Homo sapiens	Q9Y6W3	Validated Y2H	32296183
Intra	PPP1R13B	Q96KQ4	C2orf42	Homo sapiens	Q9NWW7	Validated Y2H	32296183
Intra	PPP1R13B	Q96KQ4	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	PPP1R13B	Q96KQ4	PPP1CA	Homo sapiens	P62136	Anti Bait CoIP	21998301
Intra	PPP1R13B	Q96KQ4	PPP1CA	Homo sapiens	P62136	Y2H	22321011
Intra	PPP1R13B	Q96KQ4	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	33961781
Intra	PPP1R13B	Q96KQ4	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	21998301
Intra	PPP1R13B	Q96KQ4	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	24366813
Intra	PPP1R13B	Q96KQ4	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	PPP1R13B	Q96KQ4	CDC5L	Homo sapiens	Q99459	Validated Y2H	32296183
Intra	PPP1R13B	Q96KQ4	CDC5L	Homo sapiens	Q99459	Y2H	17043677
Intra	PPP1R13B	Q96KQ4	NAP1L2	Homo sapiens	Q9ULW6	Validated Y2H	32296183
Intra	PPP1R13B	Q96KQ4	EP300	Homo sapiens	Q09472	Anti Bait CoIP	21513714
Intra	PPP1R13B	Q96KQ4	HMG20B	Homo sapiens	Q9P0W2	Validated Y2H	32296183
Intra	PPP1R13B	Q96KQ4	DGCR6L	Homo sapiens	Q9BY27	Validated Y2H	32296183
Intra	PPP1R13B	Q96KQ4	TSGA10	Homo sapiens	Q9BZW7	Validated Y2H	32296183
Intra	PPP1R13B	Q96KQ4	GINS4	Homo sapiens	Q9BRT9	Validated Y2H	32296183
Intra	PPP1R13B	Q96KQ4	KIF9	Homo sapiens	Q9HAQ2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10981	PPP1R13B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPP1R13B	MGD	MGI:1336199
Rattus norvegicus	PPP1R13B	RGD	RGD:1304651
Felis catus	PPP1R13B	VGNC	VGNC:64318
Canis familiaris	PPP1R13B	VGNC	VGNC:44881
Bos taurus	PPP1R13B	VGNC	VGNC:33224
Macaca mulatta	PPP1R13B	VGNC	VGNC:76259
Others	PPP1R13B	NCBI