2. Gene
  3. PPP1R13B - protein phosphatase 1 regulatory subunit 13B Gene

PPP1R13B - protein phosphatase 1 regulatory subunit 13B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as p85; ASPP1; p53BP2-like

Gene ID: 23368 | Gene type: protein coding

About PPP1R13B

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,733,195-103,848,814 (from NCBI)

This gene has 18 transcripts (splice variants), 282 orthologues and 1 paralogue. Broad expression in thyroid (RPKM 17.5), testis (RPKM 15.0) and 24 other tissues.

Summary

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of Apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]

PPP1R13B Products(1)

mRNA Protein Name
NM_015316.3 NP_056131.2 apoptosis-stimulating of p53 protein 1

PPP1R13B Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (898 - 980)

SH3_1

SH3_1: SH3 domain (1026 - 1072)

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  • 1090 a.a.
Protein Preferred Names Protein Names

apoptosis-stimulating of p53 protein 1

apoptosis-stimulating protein of p53, 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10981 PPP1R13B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PPP1R13B MGD MGI:1336199
Rattus norvegicus PPP1R13B RGD RGD:1304651
Felis catus PPP1R13B VGNC VGNC:64318
Canis familiaris PPP1R13B VGNC VGNC:44881
Bos taurus PPP1R13B VGNC VGNC:33224
Macaca mulatta PPP1R13B VGNC VGNC:76259