TSG101 - tumor susceptibility 101 Gene

Also Known as TSG10; VPS23

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7251

About TSG101

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,480,311-18,526,942 (from NCBI)

This gene has 12 transcripts (splice variants), 227 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 34.7), adrenal (RPKM 31.6) and 25 other tissues.

Summary

The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating Enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast Cancer and suggest that defects occur during breast Cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]

TSG101 Products (1)

mRNA	Protein	Name
NM_006292.4	NP_006283.1	tumor susceptibility gene 101 protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	19520058	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12802020	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	14519844	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	16973552	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	11595185	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	17229889	GOA
enables virion binding	IDA IDA: Inferred from direct assay	11595185	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in extracellular transport	IMP IMP: Inferred from mutant phenotype	22315426	GOA
involved in negative regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16554368	GOA
involved in negative regulation of epidermal growth factor-activated receptor activity	IMP IMP: Inferred from mutant phenotype	16973552	GOA
involved in positive regulation of exosomal secretion	IMP IMP: Inferred from mutant phenotype	22660413	GOA
involved in positive regulation of viral budding via host ESCRT complex	IMP IMP: Inferred from mutant phenotype	11595185	GOA
involved in regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	17714434	GOA
involved in regulation of extracellular exosome assembly	IMP IMP: Inferred from mutant phenotype	24105262	GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	15611048	GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	21757351	GOA
involved in viral budding	IMP IMP: Inferred from mutant phenotype	15126635	GOA
involved in viral release from host cell	IMP IMP: Inferred from mutant phenotype	11595185	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ESCRT I complex	IDA IDA: Inferred from direct assay	18005716	GOA
part of ESCRT I complex	IPI IPI: Inferred from physical interaction	18005716	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18077552	GOA
located in early endosome	IDA IDA: Inferred from direct assay	11916981	GOA
located in endosome	IDA IDA: Inferred from direct assay	17940959	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	15326289	GOA
located in late endosome	IMP IMP: Inferred from mutant phenotype	15126635	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17940959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSG101 Protein Structure

UEV

Vps23_core

0
100
200
300
390 a.a.

Protein Preferred Names	Protein Names
tumor susceptibility gene 101 protein	ESCRT-I complex subunit TSG101

TSG101 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TSG101	Q99816	ZWINT	Homo sapiens	O95229	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	ZWINT	Homo sapiens	O95229	Y2H Array	32296183
Intra	TSG101	Q99816	KRT13	Homo sapiens	A1A4E9	Y2H Prey Pooling	25416956
Intra	TSG101	Q99816	KRT13	Homo sapiens	A1A4E9	Y2H Array	25416956
Intra	TSG101	Q99816	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	TSG101	Q99816	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	TSG101	Q99816	VPS37A	Homo sapiens	Q8NEZ2-2	Y2H Array	25416956
Intra	TSG101	Q99816	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	TSG101	Q99816	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	TSG101	Q99816	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	GLI2	Homo sapiens	P10070	Phage Display	35044719
Intra	TSG101	Q99816	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	32296183
Intra	TSG101	Q99816	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	TSG101	Q99816	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	TSG101	Q99816	TRIML2	Homo sapiens	Q8N7C3	Y2H Array	32296183
Intra	TSG101	Q99816	TRIML2	Homo sapiens	Q8N7C3	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	CEP63	Homo sapiens	Q96MT8-3	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	CEP63	Homo sapiens	Q96MT8-3	Y2H Array	32296183
Intra	TSG101	Q99816	CAGE1	Homo sapiens	Q8TC20-4	Y2H Array	32296183
Intra	TSG101	Q99816	CAGE1	Homo sapiens	Q8TC20-4	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	TSG101	Q99816	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	VPS28	Homo sapiens	Q9UK41-2	Validated Y2H	32296183
Intra	TSG101	Q99816	VPS28	Homo sapiens	Q9UK41-2	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	VPS28	Homo sapiens	Q9UK41-2	Y2H Array	32296183
Intra	TSG101	Q99816	VPS28	Homo sapiens	Q9UK41-2	Y2H Array	31515488
Intra	TSG101	Q99816	SCARA5	Homo sapiens	Q6ZMJ2-2	Y2H Array	32296183
Intra	TSG101	Q99816	SCARA5	Homo sapiens	Q6ZMJ2-2	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	FAM110A	Homo sapiens	Q9BQ89	Validated Y2H	32296183
Intra	TSG101	Q99816	MGRN1	Homo sapiens	O60291	Phage Display	37219487
Intra	TSG101	Q99816	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	TSG101	Q99816	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	TSG101	Q99816	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	BRPF3	Homo sapiens	Q9ULD4-2	Y2H Array	32296183
Intra	TSG101	Q99816	BRPF3	Homo sapiens	Q9ULD4-2	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	BRPF3	Homo sapiens	Q9ULD4-2	Validated Y2H	32296183
Intra	TSG101	Q99816	HAUS1	Homo sapiens	Q96CS2	Validated Y2H	25416956
Intra	TSG101	Q99816	HAUS1	Homo sapiens	Q96CS2	Y2H Array	32296183
Intra	TSG101	Q99816	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	VPS37C	Homo sapiens	A5D8V6	Validated Y2H	25416956
Intra	TSG101	Q99816	VPS37C	Homo sapiens	A5D8V6	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	VPS37C	Homo sapiens	A5D8V6	Y2H Prey Pooling	25416956
Intra	TSG101	Q99816	VPS37C	Homo sapiens	A5D8V6	Anti Tag CoIP	35271311
Intra	TSG101	Q99816	VPS37C	Homo sapiens	A5D8V6	Y2H Array	32296183
Intra	TSG101	Q99816	PRRC1	Homo sapiens	Q96M27	Phage Display	35044719
Intra	TSG101	Q99816	PKNOX2	Homo sapiens	Q96KN3	Y2H Array	32296183
Intra	TSG101	Q99816	PKNOX2	Homo sapiens	Q96KN3	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	VPS37A	Homo sapiens	Q8NEZ2	Y2H Prey Pooling	25416956
Intra	TSG101	Q99816	VPS37A	Homo sapiens	Q8NEZ2	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	VPS37A	Homo sapiens	Q8NEZ2	Anti Tag CoIP	35271311
Intra	TSG101	Q99816	VPS37A	Homo sapiens	Q8NEZ2	Y2H Array	32296183
Intra	TSG101	Q99816	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	TSG101	Q99816	KRT75	Homo sapiens	O95678	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	KRT75	Homo sapiens	O95678	Y2H Array	32296183
Intra	TSG101	Q99816	SNAPIN	Homo sapiens	O95295	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	SNAPIN	Homo sapiens	O95295	Y2H Array	32296183
Intra	TSG101	Q99816	IQGAP1	Homo sapiens	P46940	Y2H	17853893
Intra	TSG101	Q99816	KRT18	Homo sapiens	P05783	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	KRT18	Homo sapiens	P05783	Y2H	19549727
Intra	TSG101	Q99816	KRT18	Homo sapiens	P05783	Y2H Array	32296183
Intra	TSG101	Q99816	CD2AP	Homo sapiens	Q9Y5K6	Anti Tag CoIP	17853893
Intra	TSG101	Q99816	PDCD6IP	Homo sapiens	Q8WUM4	Phage Display	37219487
Intra	TSG101	Q99816	PDCD6IP	Homo sapiens	Q8WUM4	SPR	17350572
Intra	TSG101	Q99816	KIAA1328	Homo sapiens	Q86T90	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	KIAA1328	Homo sapiens	Q86T90	Y2H Array	32296183
Intra	TSG101	Q99816	CCDC88B	Homo sapiens	A6NC98	Y2H Array	32296183
Intra	TSG101	Q99816	CCDC88B	Homo sapiens	A6NC98	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	PDLIM7	Homo sapiens	Q9NR12	Y2H Array	32296183
Intra	TSG101	Q99816	PDLIM7	Homo sapiens	Q9NR12	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	PDLIM7	Homo sapiens	Q9NR12	Validated Y2H	25416956
Intra	TSG101	Q99816	PDLIM7	Homo sapiens	Q9NR12	Validated Y2H	32296183
Intra	TSG101	Q99816	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	TSG101	Q99816	TNIP1	Homo sapiens	Q15025	Y2H Array	32296183
Intra	TSG101	Q99816	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	HSH2D	Homo sapiens	Q96JZ2	Y2H Array	32296183
Intra	TSG101	Q99816	HSH2D	Homo sapiens	Q96JZ2	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	VPS37B	Homo sapiens	Q9H9H4	Anti Tag CoIP	35271311
Intra	TSG101	Q99816	VPS37B	Homo sapiens	Q9H9H4	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	VPS37B	Homo sapiens	Q9H9H4	Validated Y2H	32296183
Intra	TSG101	Q99816	VPS37B	Homo sapiens	Q9H9H4	Y2H Array	32296183
Intra	TSG101	Q99816	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	25416956
Intra	TSG101	Q99816	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	25416956
Intra	TSG101	Q99816	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	25416956
Intra	TSG101	Q99816	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	TSG101	Q99816	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	TSG101	Q99816	SYCE1	Homo sapiens	Q8N0S2	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	SYCE1	Homo sapiens	Q8N0S2	Y2H Array	32296183
Intra	TSG101	Q99816	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	TSG101	Q99816	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	TOM1L1	Homo sapiens	O75674	Y2H	15611048
Intra	TSG101	Q99816	TOM1L1	Homo sapiens	O75674	Phage Display	37219487
Intra	TSG101	Q99816	LRSAM1	Homo sapiens	Q6UWE0	Y2H Pooling	16189514
Intra	TSG101	Q99816	LRSAM1	Homo sapiens	Q6UWE0	Y2H Prey Pooling	25416956
Intra	TSG101	Q99816	LRSAM1	Homo sapiens	Q6UWE0	Validated Y2H	25416956
Intra	TSG101	Q99816	LRSAM1	Homo sapiens	Q6UWE0	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	LRSAM1	Homo sapiens	Q6UWE0	Y2H Array	32296183
Intra	TSG101	Q99816	MZB1	Homo sapiens	Q8WU39	Y2H Array	32296183
Intra	TSG101	Q99816	MZB1	Homo sapiens	Q8WU39	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	ITPRID2	Homo sapiens	P28290	Phage Display	35044719
Intra	TSG101	Q99816	ITPRID2	Homo sapiens	P28290	Phage Display	37219487
Intra	TSG101	Q99816	PTPN23	Homo sapiens	Q9H3S7	Anti Tag CoIP	17174262
Intra	TSG101	Q99816	PTPN23	Homo sapiens	Q9H3S7	Y2H	17174262
Intra	TSG101	Q99816	LITAF	Homo sapiens	Q99732	Anti Bait CoIP	16118794
Intra	TSG101	Q99816	VPS28	Homo sapiens	Q9UK41	Anti Tag CoIP	35271311
Intra	TSG101	Q99816	VPS28	Homo sapiens	Q9UK41	Y2H Pooling	16189514
Intra	TSG101	Q99816	VPS28	Homo sapiens	Q9UK41	Validated Y2H	25416956
Intra	TSG101	Q99816	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	TSG101	Q99816	HGS	Homo sapiens	O14964	Y2H	12802020
Intra	TSG101	Q99816	HGS	Homo sapiens	O14964	Y2H Pooling	16189514
Intra	TSG101	Q99816	HGS	Homo sapiens	O14964	Anti Tag CoIP	35271311
Intra	TSG101	Q99816	CEP55	Homo sapiens	Q53EZ4	SLC	27107012
Intra	TSG101	Q99816	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	CEP55	Homo sapiens	Q53EZ4	Anti Tag CoIP	17853893
Intra	TSG101	Q99816	CEP55	Homo sapiens	Q53EZ4	BFG-2H	27107012
Intra	TSG101	Q99816	CEP55	Homo sapiens	Q53EZ4	Y2H	19549727
Intra	TSG101	Q99816	CEP55	Homo sapiens	Q53EZ4	Y2H Pooling	16189514
Intra	TSG101	Q99816	CEP55	Homo sapiens	Q53EZ4	Y2H	27107012
Intra	TSG101	Q99816	CEP55	Homo sapiens	Q53EZ4	Affinity Chrom	17853893
Intra	TSG101	Q99816	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	25416956
Intra	TSG101	Q99816	CEP55	Homo sapiens	Q53EZ4	IF	17853893
Intra	TSG101	Q99816	CEP55	Homo sapiens	Q53EZ4	Y2H Array	32296183
Intra	TSG101	Q99816	CEP55	Homo sapiens	Q53EZ4	Y2H	17853893
Intra	TSG101	Q99816	CEP55	Homo sapiens	Q53EZ4	Y2H Array	25416956
Intra	TSG101	Q99816	DAXX	Homo sapiens	Q9UER7	CoIP	15033475
Intra	TSG101	Q99816	CBY1	Homo sapiens	Q9Y3M2	Validated Y2H	32296183
Intra	TSG101	Q99816	CBY1	Homo sapiens	Q9Y3M2	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	CBY1	Homo sapiens	Q9Y3M2	Y2H Array	32296183
Intra	TSG101	Q99816	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	TSG101	Q99816	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	TSG101	Q99816	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	TSG101	Q99816	AJUBA	Homo sapiens	Q96IF1	Y2H Array	32296183
Intra	TSG101	Q99816	AJUBA	Homo sapiens	Q96IF1	Phage Display	37219487
Intra	TSG101	Q99816	AJUBA	Homo sapiens	Q96IF1	Y2H Prey Pooling	32296183
Cross	TSG101	Q99816	gag	Human immunodeficiency virus	P18095	FPS	37219487
Cross	TSG101	Q99816	gag	Human immunodeficiency virus	P18095	FPS	37100772

Cross: Cross-species interaction Intra: Intraspecies interaction

TSG101 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80924	TSG101 Antibody (YA025)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P80924A	TSG101 Antibody (YA025)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P84757	TSG101 Antibody (YA4454)	IHC-P, FC, ELISA	Human
HY-P84757A	TSG101 Antibody (YA4454)(PBS only)	IHC-P, FC, ELISA	Human
HY-P86564	TSG101 Antibody (YA6256)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hepatitis E
Charcot-Marie-Tooth Disease, Axonal, Type 2p	CMT2P Charcot-Marie-Tooth Disease Axonal Type 2p Charcot-Marie-Tooth Disease Type 2p Charcot-Marie-Tooth Neuropathy, Type 2p Charcot-Marie-Tooth Disease, Axonal, Type 2g, Formerly Cmt2g, Formerly Charcot-Marie-Tooth Neuropathy Type 2p Charcot-Marie-Toothe Disease, Axonal, Type 2p Charcot-Marie-Tooth Disease 2p Charcot-Marie-Tooth Disease, Axonal Type 2g Charcot-Marie-Tooth Neuropathy Axonal Type 2p Cmt2g Charcot-Marie-Tooth Disease, Type 2p Charcot-Marie-Tooth Disease, Axonal, Type 2g
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Charcot-Marie-Tooth Disease, Demyelinating, Type 1c	Charcot-Marie-Tooth Disease Type 1c CMT1C Hmsn1c Hmsn Ic Charcot-Marie-Tooth Disease, Type 1c Charcot-Marie-Tooth Neuropathy Type 1c Cmt, Slow Nerve Conduction Type C Charcot-Marie-Tooth Neuropathy, Type 1c Neuropathy, Hereditary Motor And Sensory, Type Ic Cmt Slow Nerve Conduction Type C Neuropathy Hereditary Motor And Sensory Type 1c Charcot-Marie-Tooth Disease 1c Charcot-Marie-Tooth Disease Demyelinating Type 1c Hereditary Motor And Sensory Neuropathy Ic Charcot-Marie-Tooth Disease, Type Ic
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17421	Tenatoprazole	Inhibitor	99.79%	Unkown
HY-RS15142	TSG101 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19082	Tsg101 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10845	KRL74	Inhibitor	/	Unkown
HY-RS25573	Tsg101 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991414	FGI-1011A6	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TSG101	VGNC	VGNC:47898
Macaca mulatta	TSG101	VGNC	VGNC:78998
Felis catus	TSG101	VGNC	VGNC:66613
Bos taurus	TSG101	VGNC	VGNC:36414
Mus musculus	TSG101	MGD	MGI:106581
Rattus norvegicus	TSG101	RGD	RGD:3909
Others	TSG101	NCBI