VPS37A - VPS37A subunit of ESCRT-I Gene

Also Known as HCRP1; PQBP2; SPG53

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 137492

About VPS37A

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,246,958-17,333,455 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 6.8), placenta (RPKM 5.0) and 25 other tissues.

Summary

This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

VPS37A Products (9)

mRNA	Protein	Name
NM_001145152.2	NP_001138624.1	vacuolar protein sorting-associated protein 37A isoform 2
NM_001363167.1	NP_001350096.1	vacuolar protein sorting-associated protein 37A isoform 3
NM_001363168.1	NP_001350097.1	vacuolar protein sorting-associated protein 37A isoform 4
NM_001363169.1	NP_001350098.1	vacuolar protein sorting-associated protein 37A isoform 4
NM_001363170.1	NP_001350099.1	vacuolar protein sorting-associated protein 37A isoform 5
NM_001363171.1	NP_001350100.1	vacuolar protein sorting-associated protein 37A isoform 5
NM_001363172.2	NP_001350101.1	vacuolar protein sorting-associated protein 37A isoform 5
NM_001363173.2	NP_001350102.1	vacuolar protein sorting-associated protein 37A isoform 1
NM_152415.3	NP_689628.2	vacuolar protein sorting-associated protein 37A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	21757351	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ESCRT I complex	IDA IDA: Inferred from direct assay	18005716	GOA
part of ESCRT I complex	IPI IPI: Inferred from physical interaction	18005716	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS37A Protein Structure

Mod_r

0
100
200
300
397 a.a.

Protein Preferred Names	Protein Names
vacuolar protein sorting-associated protein 37A	ESCRT-I complex subunit VPS37A

VPS37A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VPS37A	Q8NEZ2	NF2	Homo sapiens	P35240	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	NF2	Homo sapiens	P35240	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	NF2	Homo sapiens	P35240	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	NF2	Homo sapiens	P35240-4	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	NF2	Homo sapiens	P35240-4	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	NF2	Homo sapiens	P35240-4	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	GDAP1	Homo sapiens	Q8TB36	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	GDAP1	Homo sapiens	Q8TB36	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	GDAP1	Homo sapiens	Q8TB36	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	TSG101	Homo sapiens	Q99816	Y2H Array	25416956
Intra	VPS37A	Q8NEZ2	TSG101	Homo sapiens	Q99816	Anti Tag CoIP	33961781
Intra	VPS37A	Q8NEZ2	TSG101	Homo sapiens	Q99816	Validated Y2H	25416956
Intra	VPS37A	Q8NEZ2	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	VPS37A	Q8NEZ2	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	VPS37A	Q8NEZ2	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	VPS37A	Q8NEZ2	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	VPS37A	Q8NEZ2	PRPS1	Homo sapiens	P60891	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spastic Paraplegia 53, Autosomal Recessive	SPG53 Hereditary Spastic Paraplegia 53 Autosomal Recessive Spastic Paraplegia Type 53 Autosomal Recessive Spastic Paraplegia 53 Paraplegia, Spastic, Type 53, Autosomal Recessive
Paraplegia	Paraplegia, Lower Severe Or Complete Loss Of Motor Function In The Lower Extremities And Lower Portions Of The Trunk
Spastic Paraparesis
Spastic Paraplegia 80, Autosomal Dominant	SPG80 Hereditary Spastic Paraplegia 80 Spastic Paraplegia 80 Autosomal Dominant Doid:0112341
Pectus Carinatum	Carinatum Deformity Of The Chest
Pontocerebellar Hypoplasia, Type 2e	Pontocerebellar Hypoplasia Type 2 Pontocerebellar Hypoplasia Type 2e Pch2 PCH2E Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy Pontocerebellar Hypoplasia 2e Pcca2 Progressive Cerebello-Cerebral Atrophy Type 2 Doid:0112328 Hypoplasia, Pontocerebellar, Type 2e Pontocerebellar Hypoplasia, Type 2d Pontocerebellar Hypoplasia Type 2a
Low Compliance Bladder	Overactive Bladder Hyperactivity Of Bladder Hypertonic Bladder Hypertonicity Of Bladder Low Bladder Compliance Oab - [Overactive Bladder]
Spastic Paraplegia, Optic Atrophy, And Neuropathy	Spoan Syndrome SPOAN Spastic Paraplegia, Optic Atropy, And Neuropathy Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Spastic Paraplegia 42, Autosomal Dominant	SPG42 Hereditary Spastic Paraplegia 42 Autosomal Dominant Spastic Paraplegia Type 42 Autosomal Dominant Spastic Paraplegia 42 Paraplegia, Spastic, Type 42, Autosomal Dominant
Hypertrichosis
Spastic Paraplegia 10, Autosomal Dominant	SPG10 Hereditary Spastic Paraplegia 10 Autosomal Dominant Spastic Paraplegia Type 10 Spastic Paraplegia 10 Spastic Paraplegia 10 With Or Without Peripheral Neuropathy Autosomal Dominant Spastic Paraplegia 10 Autosomal Dominant Spastic Paraplegia Spastic Paraplegia, Autosomal Dominant Paraplegia, Spastic, Autosomal Dominant, Type 10
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15688	VPS37A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	VPS37A	VGNC	VGNC:48287
Mus musculus	VPS37A	MGD	MGI:1261835
Rattus norvegicus	VPS37A	RGD	RGD:1560016
Bos taurus	VPS37A	VGNC	VGNC:36820
Felis catus	VPS37A	VGNC	VGNC:80117
Others	VPS37A	NCBI