NF2 - NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Gene

Also Known as ACN; SCH; BANF; merlin-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4771

About NF2

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:29,603,556-29,698,600 (from NCBI)

This gene has 15 transcripts (splice variants), 205 orthologues, 6 paralogues and is associated with 128 phenotypes. Ubiquitous expression in testis (RPKM 5.3), brain (RPKM 5.2) and 25 other tissues.

Summary

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. [provided by RefSeq, May 2022]

NF2 Products (23)

mRNA	Protein	Name
NM_000268.4	NP_000259.1	merlin isoform 1
NM_001407053.1	NP_001393982.1	merlin isoform 9
NM_001407054.1	NP_001393983.1	merlin isoform 10
NM_001407055.1	NP_001393984.1	merlin isoform 11
NM_001407056.1	NP_001393985.1	merlin isoform 12
NM_001407057.1	NP_001393986.1	merlin isoform 13
NM_001407058.1	NP_001393987.1	merlin isoform 6
NM_001407059.1	NP_001393988.1	merlin isoform 14
NM_001407060.1	NP_001393989.1	merlin isoform 15
NM_001407062.1	NP_001393991.1	merlin isoform 17
NM_001407063.1	NP_001393992.1	merlin isoform 7
NM_001407064.1	NP_001393993.1	merlin isoform 18
NM_001407065.1	NP_001393994.1	merlin isoform 19
NM_001407066.1	NP_001393995.1	merlin isoform 2
NM_001407067.1	NP_001393996.1	merlin isoform 16
NM_016418.5	NP_057502.2	merlin isoform 2
NM_181825.3	NP_861546.1	merlin isoform 2
NM_181828.3	NP_861966.1	merlin isoform 5
NM_181829.3	NP_861967.1	merlin isoform 6
NM_181830.3	NP_861968.1	merlin isoform 7
NM_181831.3	NP_861969.1	merlin isoform 7
NM_181832.3	NP_861970.1	merlin isoform 2
NM_181833.3	NP_861971.1	merlin isoform 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9430655	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Schwann cell proliferation	IMP IMP: Inferred from mutant phenotype	17353411	GOA
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	9537418	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12444102	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17210637	GOA
involved in negative regulation of cell-cell adhesion	IDA IDA: Inferred from direct assay	17210637	GOA
involved in negative regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	12444102	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	9537418	GOA
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21167305	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	21167305	GOA
involved in regulation of hippo signaling	IMP IMP: Inferred from mutant phenotype	20159598	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9537418	GOA
located in early endosome	IDA IDA: Inferred from direct assay	10861283	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	9537418	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10401006	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17210637	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10401006	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NF2 Protein Structure

FERM_N

FERM_M

FERM_C

ERM

0
100
200
300
400
500
595 a.a.

Protein Preferred Names	Protein Names
merlin	bilateral acoustic neurofibromatosis

NF2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NF2	P35240	GTPBP4	Homo sapiens	Q9BZE4	Anti Tag CoIP	17210637
Intra	NF2	P35240	GTPBP4	Homo sapiens	Q9BZE4	Y2H	17210637
Intra	NF2	P35240	GTPBP4	Homo sapiens	Q9BZE4	Confocal	17210637
Intra	NF2	P35240	GTPBP4	Homo sapiens	Q9BZE4	Anti Bait CoIP	17210637
Cross	NF2	P35240	Schip1	Mus musculus	P0DPB4	Y2H	10669747
Intra	NF2	P35240	AMOT	Homo sapiens	Q4VCS5	Imaging	21481793
Intra	NF2	P35240	AMOT	Homo sapiens	Q4VCS5	Anti Bait CoIP	21481793
Intra	NF2	P35240	AMOT	Homo sapiens	Q4VCS5	Anti Tag CoIP	33961781
Intra	NF2	P35240	AMOT	Homo sapiens	Q4VCS5	TAP	24981860
Intra	NF2	P35240	AMOT	Homo sapiens	Q4VCS5-2	Anti Tag CoIP	21481793
Intra	NF2	P35240	AMOT	Homo sapiens	Q4VCS5-1	Anti Tag CoIP	21481793
Intra	NF2	P35240	LATS1	Homo sapiens	O95835	Anti Bait CoIP	24012335
Intra	NF2	P35240	LATS1	Homo sapiens	O95835	Anti Tag CoIP	24012335
Intra	NF2	P35240	MAP3K11	Homo sapiens	Q16584	Pull Down	20890305
Intra	NF2	P35240	MED28	Homo sapiens	Q9H204	Y2H	15467741
Intra	NF2	P35240	MED28	Homo sapiens	Q9H204	Pull Down	15467741
Intra	NF2	P35240	MED28	Homo sapiens	Q9H204	Anti Bait CoIP	15467741
Intra	NF2	P35240	PATJ	Homo sapiens	Q8NI35	Anti Tag CoIP	21481793
Intra	NF2	P35240	HGS	Homo sapiens	O14964	BRET	29997244
Intra	NF2	P35240	HGS	Homo sapiens	O14964	Lumier	32814053
Intra	NF2	P35240	HGS	Homo sapiens	O14964	BRET	37398436
Intra	NF2	P35240	HGS	Homo sapiens	O14964	Lumier	37398436
Cross	NF2	P35240	Ppp1r12a	Rattus norvegicus	Q10728	Anti Tag CoIP	16885985

Cross: Cross-species interaction Intra: Intraspecies interaction

NF2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81641	NF2 Antibody (YA1386)	WB	Human, Mouse, Rat
HY-P81641A	NF2 Antibody (YA1386)(PBS only)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Neurofibromatosis, Type Ii	Neurofibromatosis 2 Neurofibromatosis, Type 2 NF2 Neurofibromatosis Type Ii Bilateral Acoustic Neurofibromatosis Banf Acn Central Neurofibromatosis Neurofibromatosis, Central Type Acoustic Schwannomas, Bilateral Acoustic Neurinoma, Bilateral Bilateral Acoustic Neurinoma Bilateral Acoustic Schwannomas Familial Acoustic Neuromas
Acoustic Neuroma	Neurofibromatosis Type 2 Vestibular Schwannoma Acoustic Neurinoma Bilateral Acoustic Neurofibromatosis Nf2 Acoustic Neurilemoma Cerebellopontine Angle Tumor Neurofibromatosis Central Type Neurofibromatosis Type Ii Vestibular Neurilemmoma Acoustic Tumor Neurinoma Of The Acoustic Nerve Acoustic Neurinoma Bilateral Acoustic Schwannomas Bilateral Banf Central Neurofibromatosis Familial Acoustic Neuromas Neurofibromatosis 2 Neurofibromatosis Type 2 Merlin Schwannoma, Acoustic, Bilateral Neuroma Acoustic Neuroma, Acoustic Familial Acoustic Neuroma Familial Vestibular Schwannoma Neurofibromatosis, Central Type Nf2 - [Neurofibromatosis Type 2]
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Schwannomatosis 1	SWNTS1 Schwannomatosis-1, Susceptibility To Schwannomatosis, Somatic Neurilemmomatosis, Congenital Cutaneous Schwannomatosis-1 Congenital Cutaneous Neurilemmomatosis Schwannomatosis
Neurilemmomatosis	Schwannomatosis Neurofibromatosis Type 3 Nf3 Neurilemmomatosis Congenital Cutaneous Neurinomatosis Congenital Cutaneous Neurilemmomatosis Multiple Neurilemmomas Multiple Schwannomas Neurilemmomatosis, Congenital Cutaneous Schwannomatosis 1 Neurofibromatosis 3 Mixed Central And Peripheral Neurofibromatosis Nf3 - [Neurofibromatosis Type 3]
Spindle Cell Sarcoma	Sarcoma Sarcoma Spindle Cell Sarcoma, Spindle Cell Sarcoma - Category
Neurofibromatosis	Neurofibromatoses Acoustic Neurofibromatosis Central Neurofibromatosis Peripheral Neurofibromatosis Recklinghausen'S Neurofibromatosis Von Reklinghausen Disease Neurofibromatosis Type 1
Benign Meningioma	Meningioma, Benign
Tanycytic Ependymoma
Clear Cell Ependymoma	Cellular Ependymoma
Papillary Ependymoma	Ependymoma Papillary
Malignant Peripheral Nerve Sheath Tumor	Mpnst Malignant Neurilemmoma Neurofibrosarcoma Malignant Neurofibroma Malignant Schwannoma Neurogenic Sarcoma Schwannoma, Malignant Malignant Neoplasm Of The Peripheral Nerve Sheath Malignant Peripheral Nerve Sheath Tumors
Neurofibroma	Neurofibromas Neurofibromatoses Nerve Sheath Tumors
High Grade Ependymoma	Ependymal Neoplasm Ependymal Tumors Malignant Ependymoma Ependymal Tumor Anaplastic Ependymoma Experimental Organism Malignant Ependymoma Ependymoma Of Brain
Cellular Ependymoma	Ependymoma Classic Ependymoma Papillary Ependymoma Tanycytic Ependymoma Clear Cell Ependymoma Ependymoma, Familial Epithelial Ependymoma Who Grade Ii Ependymal Neoplasm
Transitional Meningioma	Transitional Meningioma
Neurilemmoma	Schwannoma Benign Schwannoma Neurilemoma Peripheral Fibroblastoma Psammomatous Schwannoma Neurolemmoma Schwannomas
Fibrous Meningioma	Fibroblastic Meningioma
Spinal Cord Ependymoma	Ependymal Neoplasm Of The Spinal Cord Spinal Ependymoma Ependymoma Of Spinal Cord
Neuroma
Neurofibrosarcoma	Neurosarcoma Malignant Peripheral Nerve Sheath Tumor
Anaplastic Ependymoma	Ependymoma, Anaplastic Undifferentiated Ependymoma
Meningothelial Meningioma	Meningotheliomatous Meningioma
Neurilemmoma Of The Fifth Cranial Nerve	Trigeminal Schwannoma Trigeminal Neurilemmoma
Trigeminal Nerve Neoplasm	Neoplasm Of Trigeminal Nerve Tumor Of Trigeminal Nerve
Optic Nerve Sheath Meningioma	Meningioma Of Optic Nerve Sheath
Mesothelioma, Malignant	Malignant Mesothelioma Pleural Mesothelioma MESOM Mesothelioma, Somatic Advanced Malignant Mesothelioma Asbestos-Related Malignant Mesothelioma Diffuse Malignant Mesothelioma Malignant Tumor Of Mesothelium Malignant Mesothelioma, Susceptibility To Mesothelioma Diffuse Malignant Mesothelioma Malignant Pleural Mesothelioma
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease
Malignant Pleural Mesothelioma	Malignant Mesothelioma Of Pleura Pleural Malignant Mesothelioma
Spinal Cord Glioma	Glial Tumor Of Spinal Cord Glial Neoplasm Spinal Cord Glioma Of Spinal Cord
Schwannoma Of Twelfth Cranial Nerve	Hypoglossal Schwannoma Schwannoma Of The Twelfth Cranial Nerve
Hypoglossal Nerve Disease	Hypoglossal Nerve Diseases Disorder Of 12th Nerve Disorder Of Hypoglossal [12th] Nerve Disorder Of Hypoglossal Nerve Disorder Of Xii Nerve Disorders Of The Twelfth Cranial Nerve Disorders Of 12th Cranial Nerve
Cerebellopontine Angle Tumor	Cerebellopontine Angle Tumour Neoplasm Of The Cerebellopontine Angle
Brain Meningioma	Intracranial Meningioma
Intraventricular Meningioma
Chordoid Meningioma	Meningioma, Chordoid
Cerebral Convexity Meningioma	Cerebral Hemispheric Convexity Meningioma
Intraorbital Meningioma
Parasagittal Meningioma
Psammomatous Meningioma
Sphenoorbital Meningioma
Spinal Cancer	Spinal Cord Neoplasm Spinal Cord Neoplasms Spinal Neoplasms Intraspinal Tumor Malignant Tumor Of The Spinal Cord Spinal Cord Cancer Spinal Neoplasm Tumor Of The Spinal Cord Tumors Spinal Cord Intraspinal Neoplasm Spinal Cord--Cancer
Spinal Meningioma	Spinal Cord Meningioma Meningioma, Spine Meningioma Meningioma, Benign, No Icd-O Subtype
Spinal Canal And Spinal Cord Meningioma
Childhood Meningioma	Pediatric Meningioma
Plexiform Schwannoma	Plexiform Neurilemmoma Plexiform Neurinoma
Supratentorial Meningioma
Osteoblastoma
Skull Base Cancer	Tumors Of Skull Base Skull Base Neoplasms
Skull Base Meningioma	Meningioma Of The Skull Base
Peripheral Nerve Schwannoma
Clear Cell Meningioma
Optic Nerve Neoplasm	Optic Nerve Neoplasms Neoplasm Of Optic Nerve Tumor Of Second Cranial Nerve Tumour Of Optic Nerve
Intracranial Meningioma	Meningioma
Anterior Cranial Fossa Meningioma	Meningioma Of The Anterior Fossa
Olfactory Groove Meningioma	Meningioma Of The Olfactory Groove
Angiomatous Meningioma
Central Nervous System Fibrosarcoma	Fibrosarcoma Of The Cns
Foramen Magnum Meningioma	Meningioma Of The Foramen Magnum
Benign Mesothelioma	Mesothelioma Benign Tumor Of Mesothelium Adenomatoid Tumor
Cerebral Falx Meningioma	Falcine Meningioma Falx Cerebri Meningioma
Cellular Schwannoma	Cellular Neurinoma
Glossopharyngeal Nerve Disease	Ninth Cranial Nerve Disease Glossopharyngeal Nerve Diseases Disorders Of The Ninth Cranial Nerve Disorders Of 9th Cranial Nerve
Plexiform Neurofibroma	Neurofibroma Plexiform Neurofibroma, Plexiform
Suprasellar Meningioma
Cranial Nerve Malignant Neoplasm	Cranial Nerve Neoplasms Malignant Neoplasm Of Cranial Nerve Malignant Tumor Of Cranial Nerve Malignant Tumor Of The Cranial Nerve
Intraneural Perineurioma
Cavernous Sinus Meningioma	Meningioma Of The Cavernous Sinus
Purulent Labyrinthitis	Suppurative Labyrinthitis Acute Suppurative Labyrinthitis Bacterial Labyrinthitis
Optic Nerve Glioma	Glioma Of The Optic Nerve
Facial Paralysis	Facial Palsy Bell Palsy
Facial Nerve Disease	Facial Nerve Disorder Facial Nerve Diseases Neuropathy Of Facial Nerve Disorders Of 7th Cranial Nerve Disorders Of The Seventh Cranial Nerve
Lung Meningioma	Lung Primary Meningioma Primary Pulmonary Meningioma Pulmonary Meningioma Primary Lung Meningioma
Small Intestine Leiomyoma	Leiomyoma, Small Bowel Leiomyoma Of Small Intestine
Secretory Meningioma	Meningioma
Epidural Spinal Canal Neoplasm	Extradural Tumor Epidural Neoplasms Epidural Neoplasm
Rhabdoid Meningioma	Papillary Meningioma Meningioma, Rhabdoid
Peritoneal Mesothelioma	Malignant Mesothelioma Of Peritoneum Advanced Malignant Mesothelioma Of Peritoneum Advanced Malignant Peritoneal Mesothelioma Advanced Peritoneal Malignant Mesothelioma
Microcystic Meningioma
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Cerebrum Cancer	Cerebral Cancer Neoplasm Of Cerebrum Tumor Of Cerebrum Malignant Neoplasm Of Cerebrum
Cerebral Ventricle Cancer	Cerebral Ventricle Neoplasms Cerebral Ventricle Neoplasm Intraventricular Tumor Of Brain
Cerebral Meningioma	Meningioma Of Cerebrum
Tuberculum Sellae Meningioma	Meningioma Of The Tuberculum Sellae
Sella Turcica Neoplasm	Tumor Of Sella Turcica
Peritoneum Cancer	Peritoneal Neoplasm Cancer Of Peritoneum Malignant Tumor Of Peritoneum Peritoneal Neoplasms
Melanotic Neurilemmoma	Melanotic Schwannoma Pigmented Neurilemmoma Pigmented Schwannoma
Myxopapillary Ependymoma	Ependymoma Myxopapillary
Supratentorial Cancer	Supratentorial Neoplasms Brain Neoplasm, Supratentorial Malignant Supratentorial Tumor Cancer, Supratentorial
Epithelioid Neurofibroma
Orbital Cancer	Malignant Neoplasm Of Orbit Orbital Tumor Orbital Neoplasms Neoplasm Of Orbit Proper Orbit Cancer Primary Malignant Neoplasm Of Orbit Intraorbital Cancer
Sarcomatoid Renal Cell Carcinoma	Renal Cell Carcinoma, Spindle Cell
Frontal Convexity Meningioma
Cerebellopontine Angle Meningioma	Meningioma Of The Cerebellar Pontine Angle
Posterior Pituitary Gland Neoplasm	Posterior Pituitary Tumor Neoplasm Of The Posterior Pituitary
Benign Ependymoma	Ependymoma Epithelial Ependymoma Who Grade Ii Ependymal Tumor Myxopapillary Ependymoma
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Perineurioma	Soft Tissue Perineurioma
Meninges Hemangiopericytoma	Hemangiopericytoma Of Meninges Meningeal Hemangiopericytoma
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Atypical Neurofibroma
Pleural Cancer	Pleural Neoplasms Neoplasm Of Pleura Pleural Tumor Malignant Tumor Of Pleura Pleural Cavity Cancer Primary Malignant Neoplasm Of Parietal Pleura Primary Malignant Neoplasm Of Pleura Primary Malignant Neoplasm Of Visceral Pleura
Sarcomatoid Mesothelioma	Malignant Fibrous Mesothelioma Spindled Mesothelioma
Pineal Region Meningioma	Pineal Meningioma
Sveinsson Chorioretinal Atrophy	SCRA Atrophia Areata Helicoid Peripapillary Chorioretinal Degeneration Hpcd Aa Peripapillary Chorioretinal Degeneration, Icelandic Type Helicoidal Peripapillary Chorioretinal Degeneration Atrophy, Chorioretinal, Sveinsson
Spinal Cord Astrocytoma	Astrocytoma Of Spinal Cord Spinal Astrocytoma
Tinea Capitis	Dermatophytosis Of Scalp Scalp Ringworm Dermatophytosis Of Scalp Or Beard Tinea Capitis Due To Trichophyton Rubrum Trichophyton Rubrum Tinea Capitis
Petroclival Meningioma
Labyrinthitis	Labyrinthine Disorder Inner Ear Inflammation Otitis Interna Labyrinth Hyperaemia
Supratentorial Ependymoma
Cranial Nerve Palsy	Cranial Nerve Paralysis Cranial Nerve Diseases Cranial Nerve Palsies
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Atypical Teratoid Rhabdoid Tumor	Rhabdoid Tumor Predisposition Syndrome Rtps Atypical Teratoid/Rhabdoid Tumor Rhabdoid Predisposition Syndrome Familial Posterior Fossa Brain Tumor Of Infancy Familial Rhabdoid Tumor At/Rt Atypical Teratoid Rhabdoid Tumour Atypical Teratoid/Rhabdoid Tumour Rhabdoid Tumor Of The Cns Rhabdoid Tumour Of The Cns Familial Posterior Fossa Brain Tumor Syndrome Hereditary Swi/Snf Deficiency Syndrome Atrt
Sturge-Weber Syndrome	SWS Encephalotrigeminal Angiomatosis Encephalofacial Angiomatosis Sturge-Weber-Dimitri Syndrome Sturge-Weber-Krabbe Syndrome Fourth Phacomatosis Leptomeningeal Angiomatosis Meningeal Capillary Angiomatosis Sturge-Weber-Krabbe Angiomatosis Sturge-Weber Syndrome, Somatic, Mosaic Sws Type I - Facial And Leptomeningeal Angiomas Sws Type Ii - Facial Angioma Alone, No Cns Involvement Sws Type Iii - Isolated Leptomeningeal Angiomas Sturge Weber Syndrome Angiomatosis Aculoorbital-Thalamic Syndrome Encephalofacial Hemangiomatosis Encephalofacial Hemangiomatosis Syndrome Meningo-Oculo-Facial Angiomatosis Meningofacial Angiomatosis-Cerebral Calcification Syndrome Neuroretinoangiomatosis Phakomatosis, Sturge-Weber Weber-Sturge-Dimitri Syndrome
Obstructive Hydrocephalus
Rete Ovarii Benign Neoplasm
Rete Ovarii Adenoma	Adenoma Of Rete Ovarii
Central Nervous System Benign Neoplasm	Benign Neoplasm Of The Central Nervous System
Polyp Of Corpus Uteri	Endometrial/Uterine Polyp Polyp Of Endometrium Polyp Of The Uterus Polyp, Uterus
Pleural Disease	Pleural Diseases Disorder Of Pleura Non-Neoplastic Pleural Disease Pleural Disorders Non-Neoplastic Pleural Disorder
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Peripheral Nervous System Neoplasm	Peripheral Nervous System Neoplasms Nerve Sheath Neoplasm Neoplasm Of Peripheral Nerve Tumor Of Pns Nerve Sheath Neoplasms Nerve Sheath Tumors
Spinal Cord Disease	Spinal Cord Diseases Myelopathy Bone Marrow Diseases
Basal Cell Nevus Syndrome	Nevoid Basal Cell Carcinoma Syndrome Gorlin Syndrome Nbccs BCNS Gorlin-Goltz Syndrome Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies Cerebral Gigantism Jaw Cysts Cramer Niederdellmann Syndrome Gorlin Syndrome Or Gorlin-Goltz Syndrome Naevoid Basal Cell Carcinoma Syndrome
Sarcoid Meningitis	Meningitis In Sarcoidosis
Intellectual Developmental Disorder, Autosomal Dominant 1	MRD1 Autosomal Dominant Non-Syndromic Intellectual Disability 1 Mental Retardation, Autosomal Dominant 1 Autosomal Dominant Intellectual Developmental Disorder 1
Petrous Apex Meningioma	Meningioma Of The Petrous Ridge
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Salpingitis Isthmica Nodosa
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Otosclerosis	Otospongiosis
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-400902	VT3989		99.61%	Unkown
HY-134955	VT103	Inhibitor	99.64%	Unkown
HY-158342	PROTAC TEAD degrader-1	Degrader	99.82%	Unkown
HY-163644	VT-105	Inhibitor	99.93%	Unkown
HY-155309	LM-41	Inhibitor	99.87%	Unkown
HY-155310	AF-2112	Inhibitor	99.82%	Unkown
HY-113821	1-Naphthyl phosphate potassium salt	Inhibitor	99.86%	Unkown
HY-162012	HC-258		/	Unkown
HY-181532	IAP ligand 8	Ligand	/	Unkown
HY-182672	VT101	Inhibitor	/	Unkown
HY-183728	LC-TEAD01	Inhibitor	/	Unkown
HY-RS09234	NF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181607	TEAD ligand-Linker Conjugate 3	Degrader	/	Unkown
HY-RS16884	Nf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23326	Nf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NF2	RGD	RGD:3169
Macaca mulatta	NF2	VGNC	VGNC:75324
Bos taurus	NF2	VGNC	VGNC:32026
Felis catus	NF2	VGNC	VGNC:80460
Canis familiaris	NF2	VGNC	VGNC:43762
Mus musculus	NF2	MGD	MGI:97307
Others	NF2	NCBI