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Cat. No.: HY-400902R

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VT3989 (Standard)

VT3989 (Standard) is the analytical standard of VT3989 (HY-400902). This product is intended for research and analytical applications. VT3989 is an orally active pan-TEAD autopalmitoylation inhibitor that modulates the Hippo signaling pathway. VT3989 directly binds to TEAD transcription factors to block their palmitoylation modification, thereby disrupting the formation of YAP/TAZ-TEAD complexes and inhibiting downstream oncogenic transcriptional activity. VT3989 effectively inhibits the growth of NF2-deficient schwannoma and meningioma cells and reverses the Schwann cell phenotype. In addition, VT3989 exerts a synergistic effect when combined with Osimtinib (HY-15772) in EGFR-mutant non-small cell lung cancer models, significantly delaying tumor recurrence and prolonging survival. VT3989 can be used for the research of epithelioid hemangioendothelioma, malignant pleural mesothelioma, type 2 neurofibromatosis and related advanced solid tumors.

For research use only. We do not sell to patients.

CAS No.: 2506273-81-8
Formula: C₂₁H₁₈F₃NO₃
Molecular Weight:389.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VT3989 (Standard) Chemical Structure

CAS No.: 2506273-81-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 2506273-81-8
Molecular Weight 389.37
Formula C₂₁H₁₈F₃NO₃
SMILES

OC[C@@H](C)NC(C(C=C1)=CC2=C1C(OC3=CC=C(C=C3)C(F)(F)F)=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Haddox C L, et al. SAFETY AND EARLY EFFICACY OF VT3989, A TEAD INHIBITOR, IN PATIENTS WITH ADVANCED EPITHELIOID HEMANGIOENDOTHELIOMA (EHE): A PHASE I/II STUDY[J]. ESMO Rare Cancers, 2025, 4.

[2]. Laws M T, et al. Variable Schwann cell merlin inactivation is targetable with TEAD1 inhibition in schwannomas[J]. bioRxiv, 2025: 2025.11. 15.688608.

[3]. Tang T T, et al. The TEAD autopalmitoylation inhibitor VT3989 improves efficacy and increases durability of efficacy of osimertinib in preclinical EGFR mutant tumor models[J]. Cancer Research, 2022, 82(12_Supplement): 5364-5364.

[4]. Koroleva OA, et al. The Hippo pathway as an antitumor target: time to focus on. Expert Opin Investig Drugs. 2024;33(12):1177-1185. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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