2. Gene
  3. MAP3K11 - mitogen-activated protein kinase kinase kinase 11 Gene

MAP3K11 - mitogen-activated protein kinase kinase kinase 11 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MLK3; PTK1; SPRK; MLK-3; MEKK11

Gene ID: 4296 | Gene type: protein coding

About MAP3K11

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,597,757-65,614,221 (from NCBI)

This gene has 13 transcripts (splice variants), 184 orthologues and 23 paralogues. Ubiquitous expression in spleen (RPKM 25.3), fat (RPKM 22.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

MAP3K11 Products(1)

mRNA Protein Name
NM_002419.4 NP_002410.1 mitogen-activated protein kinase kinase kinase 11

MAP3K11 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (48 - 100)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (117 - 376)

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  • 847 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 11

SH3 domain-containing proline-rich kinase

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08048 MAP3K11 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAP3K11 RGD RGD:1359261
Bos taurus MAP3K11 VGNC VGNC:31189
Felis catus MAP3K11 VGNC VGNC:68156
Mus musculus MAP3K11 MGD MGI:1346880
Canis familiaris MAP3K11 VGNC VGNC:42967