AMOT - angiomotin Gene

Homo sapiens

Gene ID: 154796 | Gene type: protein coding

About AMOT

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:112,774,877-112,840,831 (from NCBI)

This gene has 5 transcripts (splice variants), 203 orthologues and 2 paralogues. Broad expression in placenta (RPKM 13.4), brain (RPKM 9.3) and 21 other tissues.

Summary

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

AMOT Products(4)

mRNA	Protein	Name
NM_001113490.2	NP_001106962.1	angiomotin isoform 1
NM_001386998.1	NP_001373927.1	angiomotin isoform 1
NM_001386999.1	NP_001373928.1	angiomotin isoform 1
NM_133265.5	NP_573572.1	angiomotin isoform 2

AMOT Protein Structure

Angiomotin_C

0
200
400
600
800
1000
1084 a.a.

Protein Preferred Names

Protein Names

angiomotin

Related Diseases

Diseases

Alias

Papilloma

Papillomatosis

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00663	AMOT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AMOT	VGNC	VGNC:37835
Felis catus	AMOT	VGNC	VGNC:59769
Rattus norvegicus	AMOT	RGD	RGD:1564027
Mus musculus	AMOT	MGD	MGI:108440
Bos taurus	AMOT	VGNC	VGNC:25870
Macaca mulatta	AMOT	VGNC	VGNC:69627