ARHGAP17 - Rho GTPase activating protein 17 Gene

Also Known as PP367; RICH1; WBP15; MST066; MST110; NADRIN; PP4534; RICH-1; MSTP038; MSTP066; MSTP110

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55114

About ARHGAP17

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:24,919,389-25,015,369 (from NCBI)

This gene has 20 transcripts (splice variants), 1 gene allele, 290 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 24.3), lymph node (RPKM 19.6) and 25 other tissues.

Summary

RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004]

ARHGAP17 Products (2)

mRNA Protein Name
NM_001006634.3 NP_001006635.1 rho GTPase-activating protein 17 isoform 1
NM_018054.6 NP_060524.4 rho GTPase-activating protein 17 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21481793 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP17 Protein Structure

BAR

BAR: BAR domain (1 - 238)

RhoGAP

RhoGAP: RhoGAP domain (268 - 412)

  • 0
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  • 400
  • 600
  • 800
  • 881 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 17

  • RhoGAP interacting with CIP4 homologs 1

ARHGAP17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARHGAP17 Q68EM7 AMOT Homo sapiens Q4VCS5
Pull Down
21481793
Intra
ARHGAP17 Q68EM7 SH3BP1 Homo sapiens Q9Y3L3
Anti Tag CoIP
33961781
Intra
ARHGAP17 Q68EM7 SH3BP1 Homo sapiens Q9Y3L3
Anti Tag CoIP
35271311
Intra
ARHGAP17 Q68EM7 SH3BP1 Homo sapiens Q9Y3L3
Anti Tag CoIP
28514442
Intra
ARHGAP17 Q68EM7 AMOT Homo sapiens Q4VCS5-2
Anti Tag CoIP
21481793
Intra
ARHGAP17 Q68EM7 TRIP10 Homo sapiens Q15642-2
Y2H Prey Pooling
32296183
Intra
ARHGAP17 Q68EM7 TRIP10 Homo sapiens Q15642-2
Y2H Array
32296183
Intra
ARHGAP17 Q68EM7 TRIP10 Homo sapiens Q15642
Y2H Array
25416956
Intra
ARHGAP17 Q68EM7 TRIP10 Homo sapiens Q15642
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00917 ARHGAP17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARHGAP17 RGD RGD:628767
Canis familiaris ARHGAP17 VGNC VGNC:38048
Macaca mulatta ARHGAP17 VGNC VGNC:99484
Mus musculus ARHGAP17 MGD MGI:1917747
Felis catus ARHGAP17 VGNC VGNC:59877
Bos taurus ARHGAP17 VGNC VGNC:26077
Others ARHGAP17 NCBI